公开(公告)号：EP2455389A4

公开(公告)日：2013-06-19

申请号：EP10799822

申请日：2010-07-12

申请人： NAT INST OF ADVANCED IND SCIEN ,  UNIV NAGOYA CITY ,  NAT CT FOR GLOBAL HEALTH & MEDICINE

发明人： NARIMATSU HISASHI ,  HIRABAYASHI JUN ,  IKEHARA YUZURU ,  ANGATA TAKASHI ,  KAJI HIROYUKI ,  KUNO ATSUSHI ,  OHKURA TAKASHI ,  SHIKANAI TOSHIHIDE ,  SOGABE MAKI ,  TOGAYACHI AKIRA ,  OCHOU MAKOTO ,  TANAKA YASUHITO ,  MIZOKAMI MASASHI

IPC分类号： C07K9/00 ,  C07K14/47 ,  G01N33/53

CPC分类号： C07K9/00 ,  C07K14/47 ,  G01N33/57438 ,  G01N33/57469 ,  G01N2400/02 ,  G01N2800/085

摘要： The present invention is directed to developing a glycan markers capable of detecting a hepatic disease, and more specifically to developing a glycan marker indicating a hepatic disease-state. Furthermore, the present invention is also directed to developing a glycan marker capable of distinguishing hepatic disease-states with the progress of hepatocarcinoma. The present inventors identified, among the serum glycoproteins, glycopeptides and glycoproteins in which a glycan structure specifically changes due to a hepatic diseases including hepatocarcinoma and provide these as novel glycan markers (glycopeptide and glycoprotein) specific to hepatic disease-states.

摘要翻译： 本发明涉及开发能够检测肝脏疾病的聚糖标记物，更具体地说，涉及发展表达肝病状态的聚糖标记物。 此外，本发明还涉及开发能够区分肝脏疾病状态与肝癌进展的聚糖标记物。 本发明人鉴定了由于肝脏疾病（包括肝癌）而导致的聚糖结构特异性变化的糖蛋白和糖蛋白，并将其作为肝细胞特异性的新型聚糖标记（糖肽和糖蛋白）而鉴定出来。

公开(公告)号：EP2617730A4

公开(公告)日：2014-01-01

申请号：EP11825097

申请日：2011-09-09

申请人： NAT INST OF ADVANCED IND SCIEN ,  UNIV TOKYO MEDICAL

发明人： NARIMATSU HISASHI ,  TOGAYACHI AKIRA ,  IKEHARA YUZURU ,  KAJI HIROYUKI ,  KUNO ATSUSHI ,  OHKURA TAKASHI ,  MATSUZAKI HIDEKI ,  HIRAO YOSHITOSHI ,  IWAKI JUN ,  ABE MINAKO ,  NOMURA MASAHARU ,  NOGUCHI MASAYUKI

IPC分类号： C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/705 ,  C07K14/78 ,  C07K14/82 ,  C07K16/18 ,  C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  C12N9/14 ,  C12N9/16 ,  C12N9/26 ,  C12N9/64 ,  C12Q1/02 ,  G01N33/574

CPC分类号： G01N33/6893 ,  C07K14/4748 ,  C07K16/28 ,  C07K16/3023 ,  G01N33/574 ,  G01N33/57423 ,  G01N2440/38

摘要： An object of the present invention is to develop and provide a lung cancer differential marker with which lung cancer can be diagnosed conveniently and highly sensitively without depending only on increase or decrease in protein expression level between cancer patients and healthy persons. Another object of the present invention is to develop and provide a glycan marker capable of distinguishing histological types of lung cancer. Of serum glycoproteins, glycopeptide and glycoprotein groups whose glycan structures were altered specifically in lung cancer cell culture supernatants were identified, and they are provided as lung cancer differential markers.

摘要翻译： 本发明的目的是开发和提供肺癌鉴别标记物，其可以方便和高度灵敏地诊断肺癌，而不依赖于癌症患者和健康人之间的蛋白质表达水平的增加或降低。 本发明的另一个目的是开发和提供能区分肺癌组织学类型的聚糖标记。 确定了在肺癌细胞培养上清液中特异性改变其聚糖结构的血清糖蛋白，糖肽和糖蛋白，并将其作为肺癌鉴别标记提供。