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公开(公告)号：EP2617730A4
公开(公告)日：2014-01-01
申请号：EP11825097
申请日：2011-09-09
发明人： NARIMATSU HISASHI , TOGAYACHI AKIRA , IKEHARA YUZURU , KAJI HIROYUKI , KUNO ATSUSHI , OHKURA TAKASHI , MATSUZAKI HIDEKI , HIRAO YOSHITOSHI , IWAKI JUN , ABE MINAKO , NOMURA MASAHARU , NOGUCHI MASAYUKI
IPC分类号： C07K7/06 , C07K7/08 , C07K14/47 , C07K14/705 , C07K14/78 , C07K14/82 , C07K16/18 , C07K16/28 , C07K16/32 , C07K16/40 , C12N9/14 , C12N9/16 , C12N9/26 , C12N9/64 , C12Q1/02 , G01N33/574
CPC分类号： G01N33/6893 , C07K14/4748 , C07K16/28 , C07K16/3023 , G01N33/574 , G01N33/57423 , G01N2440/38
摘要： An object of the present invention is to develop and provide a lung cancer differential marker with which lung cancer can be diagnosed conveniently and highly sensitively without depending only on increase or decrease in protein expression level between cancer patients and healthy persons. Another object of the present invention is to develop and provide a glycan marker capable of distinguishing histological types of lung cancer. Of serum glycoproteins, glycopeptide and glycoprotein groups whose glycan structures were altered specifically in lung cancer cell culture supernatants were identified, and they are provided as lung cancer differential markers.
摘要翻译： 本发明的目的是开发和提供肺癌鉴别标记物，其可以方便和高度灵敏地诊断肺癌，而不依赖于癌症患者和健康人之间的蛋白质表达水平的增加或降低。 本发明的另一个目的是开发和提供能区分肺癌组织学类型的聚糖标记。 确定了在肺癌细胞培养上清液中特异性改变其聚糖结构的血清糖蛋白，糖肽和糖蛋白，并将其作为肺癌鉴别标记提供。
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2.发明公开SUGAR CHAIN MARKER AS MEASURE OF DISEASE CONDITIONS OF HEPATIC DISEASES 审中-公开ZUCKERKETTENMARKER ALS MASSSTABFÜRDIE KRANKHEITSSTADIEN VON LEBERERKRANKUNGEN
公开(公告)号：EP2455389A4
公开(公告)日：2013-06-19
申请号：EP10799822
申请日：2010-07-12
发明人： NARIMATSU HISASHI , HIRABAYASHI JUN , IKEHARA YUZURU , ANGATA TAKASHI , KAJI HIROYUKI , KUNO ATSUSHI , OHKURA TAKASHI , SHIKANAI TOSHIHIDE , SOGABE MAKI , TOGAYACHI AKIRA , OCHOU MAKOTO , TANAKA YASUHITO , MIZOKAMI MASASHI
CPC分类号： C07K9/00 , C07K14/47 , G01N33/57438 , G01N33/57469 , G01N2400/02 , G01N2800/085
摘要： The present invention is directed to developing a glycan markers capable of detecting a hepatic disease, and more specifically to developing a glycan marker indicating a hepatic disease-state. Furthermore, the present invention is also directed to developing a glycan marker capable of distinguishing hepatic disease-states with the progress of hepatocarcinoma. The present inventors identified, among the serum glycoproteins, glycopeptides and glycoproteins in which a glycan structure specifically changes due to a hepatic diseases including hepatocarcinoma and provide these as novel glycan markers (glycopeptide and glycoprotein) specific to hepatic disease-states.
摘要翻译： 本发明涉及开发能够检测肝脏疾病的聚糖标记物，更具体地说，涉及发展表达肝病状态的聚糖标记物。 此外，本发明还涉及开发能够区分肝脏疾病状态与肝癌进展的聚糖标记物。 本发明人鉴定了由于肝脏疾病（包括肝癌）而导致的聚糖结构特异性变化的糖蛋白和糖蛋白，并将其作为肝细胞特异性的新型聚糖标记（糖肽和糖蛋白）而鉴定出来。
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3.发明公开ANTIBODY FOR DETECTING EPITHELIAL OVARIAN CANCER MARKER AND METHOD FOR DIAGNOSING EPITHELIAL OVARIAN CANCER 有权抗体卵巢癌标记物在制备用于诊断上皮性卵巢癌的上皮细胞和检测方法
公开(公告)号：EP2738250A4
公开(公告)日：2015-04-08
申请号：EP12817890
申请日：2012-07-26
发明人： SOGABE MAKI , KUBOTA TOMOMI , TOGAYACHI AKIRA , IKEHARA YUZURU , NARIMATSU HISASHI , SAWAKI HIROMICHI , NAKANISHI HAYAO , NAKANISHI TORU
IPC分类号： C12N15/09 , C07K16/40 , C12N5/10 , C12N9/10 , C12P21/08 , G01N33/573 , G01N33/574
CPC分类号： G01N33/57449 , C07K16/40 , C07K2317/33 , C07K2317/34
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4.发明公开NOVEL N-ACETYLGLUCOSAMINE TRANSFERASE, NUCLEIC ACID ENCODING THE SAME AND USE THEREOF IN DIAGNOSING CANCER AND/OR TUMOR 有权新的N-乙酰葡糖胺转移该编码NUCLEIC及其用途在癌症和/或肿瘤的诊断
公开(公告)号：EP1491630A4
公开(公告)日：2006-02-22
申请号：EP03712699
申请日：2003-03-14
发明人： NARIMATSU HISASHI , INABA NIRO , TOGAYACHI AKIRA
CPC分类号： C12N9/1051 , C12Q1/6886 , C12Q2600/158
摘要： An enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Galβ1-4Glc or Galβ1-4GlcNAc-group via a β-1,3 bond; a nucleic acid encoding the same; and a method of diagnosing cancer and/or tumor, in particular, digestive cancer and/or tumor using the expression dose of a gene of the above enzyme as an indication. A gene of a novel enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Galβ1-4Glc or Galβ1-4GlcNAc-group via a β-1,3 bond is cloned from human stomach cells and its base sequence is determined. Then this enzyme is expressed. Since this enzyme is scarcely or never produced in cancer and/or tumor, in particular, digestive cancer and/or tumor cells, cancer and/or tumor can be diagnosed with the use of the expression of the enzyme gene as an indication.
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5.发明公开ANTIBODY FOR DETECTING EPITHELIAL OVARIAN CANCER MARKER AND METHOD FOR DIAGNOSING EPITHELIAL OVARIAN CANCER 审中-公开抗体上皮性卵巢癌和方法标记技术用于诊断卵巢癌上皮检测
公开(公告)号：EP2738252A4
公开(公告)日：2015-04-01
申请号：EP12818196
申请日：2012-07-26
发明人： SOGABE MAKI , KUBOTA TOMOMI , TOGAYACHI AKIRA , IKEHARA YUZURU , NARIMATSU HISASHI , SAWAKI HIROMICHI , NAKANISHI HAYAO , NAKANISHI TORU
IPC分类号： C12N15/09 , C07K16/30 , C07K16/40 , C12N5/10 , C12N5/16 , C12N9/10 , C12P21/08 , G01N33/573 , G01N33/574
CPC分类号： G01N33/57449 , C07K16/3069 , C07K16/40 , C12N5/163
摘要： The present invention provides an antibody capable of specifically recognizing and detecting the highly specific cancer marker with respect to the epithelial ovarian cancer, or a fragment of the antibody. The present invention provides an anti-²1,3-N-acetylglucosaminyltransferase 3 antibody for diagnosis of epithelial ovarian cancer, i.e., an antibody for detection of a glycosyltransferase ²1,3-N-acetylglucosaminyltransferase 3 as an epithelial ovarian cancer marker. The antibody recognizes, as an epitope, a part of a polypeptide of the enzyme consisting of the amino acid sequence represented by SEQ ID NO: 1.
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6.发明公开GLYCOSYLTRANSFERASE, NUCLEIC ACID ENCODING THE GLYCOSYLTRANSFERASE AND METHOD OF TESTING CANCERATION USING THE NUCLEIC ACID 审中-公开糖基转移酶，糖基转移酶编码核酸以及测试癌变使用方法NUCLEIC
公开(公告)号：EP1589110A4
公开(公告)日：2006-06-07
申请号：EP03786376
申请日：2003-12-26
发明人： NARIMATSU HISASHI , KUDO TAKASHI , TOGAYACHI AKIRA , HIRUMA TORU
CPC分类号： C12N9/1051
摘要： A cancer marker nucleic acid which is hybridizable with the base sequence represented by SEQ ID NO:1 or a base sequence complementary thereto under stringent conditions; and a method of testing canceration wherein a biological sample is judged as cancerous in the case of showing a significantly higher transcriptional level of the above nucleic acid than that in a normal biological sample employed as a control. A β1,3-N-acetyl-D-glucosamine transferase protein having an activity of transferring N-acetyl-D-glucosamine from a donor substrate to a receptor substrate via a β1,3-bond.
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7.发明公开BETA 1,3-N-ACETYL-D-GALACTOSAMINE TRANSFERASE PROTEIN, NUCLEIC ACID ENCODING THE SAME AND METHOD OF EXAMINING CANCERATION USING THE SAME 有权β-1,3-N-乙酰-D-半乳糖胺转移蛋白，DIESES CODEERENDENUKLEINSÄURLUND VERFAHREN ZUR UNTERSUCHUNG DER KREBSBILDUNG UNTER VERWENDUNG DAVON
公开(公告)号：EP1595955A4
公开(公告)日：2006-05-10
申请号：EP04704763
申请日：2004-01-23
发明人： NARIMATSU HISASHI , TOGAYACHI AKIRA , INABA NIRO , HIRUMA TORU , ISHIZUKA YASUKO
CPC分类号： C12N9/1051
摘要： An N-acetyl-D-galactosamine transferase protein characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine via a beta1,3-bond. It preferably has an amino sequence represented by SEQ ID NO:2 or 4. A method of examining canceration by using a nucleic acid for assaying which is hybridizable under stringent conditions with a base sequence represented by SEQ ID NO:1 or 3 or a base sequence being complementary to at least one of these base sequences.
摘要翻译： 一种N-乙酰-D-半乳糖胺转移酶蛋白，其特征在于通过β1,3-键将N-乙酰-D-半乳糖胺转移到N-乙酰-D-葡糖胺。 它优选具有由SEQ ID NO：2或4表示的氨基酸序列。通过使用用于测定在严格条件下与SEQ ID NO：1或3代表的碱基序列杂交的核酸或碱基 序列与这些碱基序列中的至少一个互补。
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