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1.发明公开PLURIPOTENT STEM CELL-DERIVED BROWN ADIPOCYTES, PLURIPOTENT STEM CELL-DERIVED CELL AGGREGATE, METHOD FOR PRODUCING SAME, AND CELL THERAPY AND MEDICAL THERAPY THEREFOR 审中-公开关多能干WON褐色脂肪细胞OFF多能干获得的细胞单元，加工用于生产和细胞治疗和医学治疗中的
公开(公告)号：EP2703481A4
公开(公告)日：2014-11-12
申请号：EP12776134
申请日：2012-04-26
发明人： SAEKI KUMIKO , YUO AKIRA , NISHIO MIWAKO , KAWASAKI MASAKO , SAEKI KOICHI , HASEGAWA MAMORU
CPC分类号： A61K35/35 , A61K35/28 , C12N5/0653 , C12N2501/105 , C12N2501/155 , C12N2501/165 , C12N2501/2306 , C12N2501/26 , C12N2506/45
摘要： Provided are a method of producing brown adipocytes from pluripotent stem cells, a method of producing cell aggregates as an intermediate product thereof, pluripotent stem cell-derived cell aggregates and pluripotent stem cell-derived brown adipocytes produced by these methods, and cell therapy using the pluripotent stem cell-derived brown adipocytes. In the method of producing brown adipocytes from pluripotent stem cells, cell aggregates are produced from pluripotent stem cells by a method including the step (A), and brown adipocytes are prepared from the cell aggregates by a method including the step (B). The step (A) is a step of producing cell aggregates by non-adhesive culture of pluripotent stem cells in serum-free environment in the presence of a hematopoietic cytokine, and the step (B) is a step of producing brown adipocytes by adhesion culture of the cell aggregates in the presence of a hematopoietic cytokine.
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2.发明公开HIGHLY FUNCTIONAL LIVER CELLS DERIVED FROM PLURIPOTENT STEM CELLS, METHOD FOR PRODUCING SAME, AND METHOD FOR TESTING METABOLISM/TOXICITY OF DRUG 审中-公开关多能干衍生的高功能肝细胞，用于用于测试的代谢毒性毒品生产和方法
公开(公告)号：EP2671944A4
公开(公告)日：2014-12-03
申请号：EP12742430
申请日：2012-01-30
发明人： YUO AKIRA , SAEKI KUMIKO , NAKAMURA NAOKO , MATSUYAMA SATOKO , NISHIO MIWAKO , SAEKI KOICHI , HASEGAWA MAMORU
CPC分类号： C12N5/067 , C12N2500/90 , C12N2501/115 , C12N2501/155 , C12N2501/16 , C12N2501/237 , C12N2501/39 , C12N2501/41 , C12N2501/415 , C12N2506/02 , C12N2506/45 , G01N33/5014 , G01N33/5067
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3.发明公开METHOD AND SPECIMEN FOR DETECTING SENSITIVITY TO ISONIAZID IN TUBERCLE BACILLUS 有权程序和编写灵敏度的异烟肼AT结核菌的检测
公开(公告)号：EP2322659A4
公开(公告)日：2012-01-04
申请号：EP09773502
申请日：2009-07-01
CPC分类号： C12Q1/689 , C12Q2600/156 , G01N33/5695 , G01N2333/35 , G01N2800/44
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公开(公告)号：EP2233585A4
公开(公告)日：2011-01-19
申请号：EP08862330
申请日：2008-12-15
发明人： YASUDA KAZUKI , KASUGA MASATO , KADOWAKI TAKASHI , FURUTA HIROTO , MAKINO HIDEICHI , IWASAKI NAOKO , HORIKAWA YUKIO , YAMAGATA KAZUYA , OKA YOSHITOMO
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G01N2500/04 , G01N2500/10 , G01N2800/042
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5.发明公开SUGAR CHAIN MARKER AS MEASURE OF DISEASE CONDITIONS OF HEPATIC DISEASES 审中-公开ZUCKERKETTENMARKER ALS MASSSTABFÜRDIE KRANKHEITSSTADIEN VON LEBERERKRANKUNGEN
公开(公告)号：EP2455389A4
公开(公告)日：2013-06-19
申请号：EP10799822
申请日：2010-07-12
发明人： NARIMATSU HISASHI , HIRABAYASHI JUN , IKEHARA YUZURU , ANGATA TAKASHI , KAJI HIROYUKI , KUNO ATSUSHI , OHKURA TAKASHI , SHIKANAI TOSHIHIDE , SOGABE MAKI , TOGAYACHI AKIRA , OCHOU MAKOTO , TANAKA YASUHITO , MIZOKAMI MASASHI
CPC分类号： C07K9/00 , C07K14/47 , G01N33/57438 , G01N33/57469 , G01N2400/02 , G01N2800/085
摘要： The present invention is directed to developing a glycan markers capable of detecting a hepatic disease, and more specifically to developing a glycan marker indicating a hepatic disease-state. Furthermore, the present invention is also directed to developing a glycan marker capable of distinguishing hepatic disease-states with the progress of hepatocarcinoma. The present inventors identified, among the serum glycoproteins, glycopeptides and glycoproteins in which a glycan structure specifically changes due to a hepatic diseases including hepatocarcinoma and provide these as novel glycan markers (glycopeptide and glycoprotein) specific to hepatic disease-states.
摘要翻译： 本发明涉及开发能够检测肝脏疾病的聚糖标记物，更具体地说，涉及发展表达肝病状态的聚糖标记物。 此外，本发明还涉及开发能够区分肝脏疾病状态与肝癌进展的聚糖标记物。 本发明人鉴定了由于肝脏疾病（包括肝癌）而导致的聚糖结构特异性变化的糖蛋白和糖蛋白，并将其作为肝细胞特异性的新型聚糖标记（糖肽和糖蛋白）而鉴定出来。
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6.发明公开
公开(公告)号：EP2455758A4
公开(公告)日：2013-01-16
申请号：EP10799855
申请日：2010-07-14
申请人： NAT INST OF ADVANCED IND SCIEN , UNIV NAGOYA CITY , NAT CT FOR GLOBAL HEALTH & MEDICINE , SYSMEX CORP
发明人： NARIMATSU HISASHI , IKEHARA YUZURU , KUNO ATSUSHI , SOGABE MAKI , TANAKA YASUHITO , MIZOKAMI MASASHI , ITO KIYOAKI , MATSUBARA SHUNSUKE , TSURUNO CHIKAYUKI , TAKAHAMA YOUICHI , KAGAWA TAKASHI , NAGAI SHINYA
CPC分类号： G01N33/68 , C07K14/4726 , C07K14/473 , G01N33/5308 , G01N33/6893 , G01N2333/4724 , G01N2333/4728 , G01N2400/00 , G01N2400/02 , G01N2800/085 , Y10T436/143333
摘要： An object of the present invention is to provide a method for measuring a glycan-marker glycoprotein, by which liver disease can be detected with higher accuracy than is possible with conventional methods. Also, an object of the present invention is to provide a method for examining liver disease, by which liver disease can be detected with higher accuracy than is possible with conventional methods. Also, an object of the present invention is to provide a reagent for quantitative determination of a glycoprotein, which is used for the above measurement methods. Furthermore, an object of the present invention is to provide a glycan-marker glycoprotein as an index for clinical conditions of liver disease, which is capable of identifying the clinical conditions of liver disease depending on the progress of liver disease. The method for measuring a glycoprotein is characterized in that : the glycoprotein is at least one glycoprotein selected from alpha-1-acid glycoprotein (AGP) and Mac-2-binding protein (M2BP) contained in a sample collected from a subject; when the glycoprotein is AGP, AGP binding to a first lectin selected from AOL and MAL is measured; and when the glycoprotein is M2BP, M2BP binding to a second lectin selected from WFA, BPL, AAL, RCA120, and TJAII is measured.
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7.发明公开METHOD AND TEST STRIP FOR DETECTING SENSITIVITY TO ISONIAZID IN MYCOBACTERIUM TUBERCULOSIS 审中-公开方法和测试条SENSITIVTÄT对异烟肼结核分枝杆菌检测
公开(公告)号：EP2295600A4
公开(公告)日：2012-01-04
申请号：EP09773501
申请日：2009-07-01
CPC分类号： C12Q1/689 , C12Q2600/156 , G01N33/5695 , G01N2333/35 , G01N2800/44
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