公开(公告)号：EP2455389A4

公开(公告)日：2013-06-19

申请号：EP10799822

申请日：2010-07-12

申请人： NAT INST OF ADVANCED IND SCIEN ,  UNIV NAGOYA CITY ,  NAT CT FOR GLOBAL HEALTH & MEDICINE

发明人： NARIMATSU HISASHI ,  HIRABAYASHI JUN ,  IKEHARA YUZURU ,  ANGATA TAKASHI ,  KAJI HIROYUKI ,  KUNO ATSUSHI ,  OHKURA TAKASHI ,  SHIKANAI TOSHIHIDE ,  SOGABE MAKI ,  TOGAYACHI AKIRA ,  OCHOU MAKOTO ,  TANAKA YASUHITO ,  MIZOKAMI MASASHI

IPC分类号： C07K9/00 ,  C07K14/47 ,  G01N33/53

CPC分类号： C07K9/00 ,  C07K14/47 ,  G01N33/57438 ,  G01N33/57469 ,  G01N2400/02 ,  G01N2800/085

摘要： The present invention is directed to developing a glycan markers capable of detecting a hepatic disease, and more specifically to developing a glycan marker indicating a hepatic disease-state. Furthermore, the present invention is also directed to developing a glycan marker capable of distinguishing hepatic disease-states with the progress of hepatocarcinoma. The present inventors identified, among the serum glycoproteins, glycopeptides and glycoproteins in which a glycan structure specifically changes due to a hepatic diseases including hepatocarcinoma and provide these as novel glycan markers (glycopeptide and glycoprotein) specific to hepatic disease-states.

摘要翻译： 本发明涉及开发能够检测肝脏疾病的聚糖标记物，更具体地说，涉及发展表达肝病状态的聚糖标记物。 此外，本发明还涉及开发能够区分肝脏疾病状态与肝癌进展的聚糖标记物。 本发明人鉴定了由于肝脏疾病（包括肝癌）而导致的聚糖结构特异性变化的糖蛋白和糖蛋白，并将其作为肝细胞特异性的新型聚糖标记（糖肽和糖蛋白）而鉴定出来。

公开(公告)号：EP2455758A4

公开(公告)日：2013-01-16

申请号：EP10799855

申请日：2010-07-14

申请人： NAT INST OF ADVANCED IND SCIEN ,  UNIV NAGOYA CITY ,  NAT CT FOR GLOBAL HEALTH & MEDICINE ,  SYSMEX CORP

发明人： NARIMATSU HISASHI ,  IKEHARA YUZURU ,  KUNO ATSUSHI ,  SOGABE MAKI ,  TANAKA YASUHITO ,  MIZOKAMI MASASHI ,  ITO KIYOAKI ,  MATSUBARA SHUNSUKE ,  TSURUNO CHIKAYUKI ,  TAKAHAMA YOUICHI ,  KAGAWA TAKASHI ,  NAGAI SHINYA

IPC分类号： G01N33/68 ,  C07K14/47 ,  G01N33/53

CPC分类号： G01N33/68 ,  C07K14/4726 ,  C07K14/473 ,  G01N33/5308 ,  G01N33/6893 ,  G01N2333/4724 ,  G01N2333/4728 ,  G01N2400/00 ,  G01N2400/02 ,  G01N2800/085 ,  Y10T436/143333

摘要： An object of the present invention is to provide a method for measuring a glycan-marker glycoprotein, by which liver disease can be detected with higher accuracy than is possible with conventional methods. Also, an object of the present invention is to provide a method for examining liver disease, by which liver disease can be detected with higher accuracy than is possible with conventional methods. Also, an object of the present invention is to provide a reagent for quantitative determination of a glycoprotein, which is used for the above measurement methods. Furthermore, an object of the present invention is to provide a glycan-marker glycoprotein as an index for clinical conditions of liver disease, which is capable of identifying the clinical conditions of liver disease depending on the progress of liver disease. The method for measuring a glycoprotein is characterized in that : the glycoprotein is at least one glycoprotein selected from alpha-1-acid glycoprotein (AGP) and Mac-2-binding protein (M2BP) contained in a sample collected from a subject; when the glycoprotein is AGP, AGP binding to a first lectin selected from AOL and MAL is measured; and when the glycoprotein is M2BP, M2BP binding to a second lectin selected from WFA, BPL, AAL, RCA120, and TJAII is measured.

公开(公告)号：EP2405269A4

公开(公告)日：2012-08-15

申请号：EP10748464

申请日：2010-02-23

申请人： NAT INST OF ADVANCED IND SCIEN ,  UNIV TSUKUBA

发明人： KUNO ATSUSHI ,  HIRABAYASHI JUN ,  MATSUDA ATSUSHI ,  NARIMATSU HISASHI ,  IKEHARA YUZURU ,  SHODA JUNICHI ,  KAWAMOTO TORU

IPC分类号： G01N33/574 ,  G01N21/64 ,  G01N37/00

CPC分类号： G01N21/648 ,  G01N33/57407 ,  G01N33/57438 ,  G01N33/57446

公开(公告)号：EP2782430A4

公开(公告)日：2015-07-01

申请号：EP12851481

申请日：2012-10-22

申请人： NAT INST OF ADVANCED IND SCIEN

发明人： SAKAKITA HAJIME ,  IKEHARA YUZURU ,  KIYAMA SATORU

IPC分类号： H05H1/00 ,  A61B17/00 ,  A61B18/00 ,  A61B18/04 ,  H05H1/46

CPC分类号： A61N5/1064 ,  A61B18/042 ,  A61B2017/00057 ,  A61B2018/00642 ,  A61B2018/00827 ,  A61B2018/00892 ,  H05H1/0081

公开(公告)号：EP2617730A4

公开(公告)日：2014-01-01

申请号：EP11825097

申请日：2011-09-09

申请人： NAT INST OF ADVANCED IND SCIEN ,  UNIV TOKYO MEDICAL

发明人： NARIMATSU HISASHI ,  TOGAYACHI AKIRA ,  IKEHARA YUZURU ,  KAJI HIROYUKI ,  KUNO ATSUSHI ,  OHKURA TAKASHI ,  MATSUZAKI HIDEKI ,  HIRAO YOSHITOSHI ,  IWAKI JUN ,  ABE MINAKO ,  NOMURA MASAHARU ,  NOGUCHI MASAYUKI

IPC分类号： C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/705 ,  C07K14/78 ,  C07K14/82 ,  C07K16/18 ,  C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  C12N9/14 ,  C12N9/16 ,  C12N9/26 ,  C12N9/64 ,  C12Q1/02 ,  G01N33/574

CPC分类号： G01N33/6893 ,  C07K14/4748 ,  C07K16/28 ,  C07K16/3023 ,  G01N33/574 ,  G01N33/57423 ,  G01N2440/38

摘要： An object of the present invention is to develop and provide a lung cancer differential marker with which lung cancer can be diagnosed conveniently and highly sensitively without depending only on increase or decrease in protein expression level between cancer patients and healthy persons. Another object of the present invention is to develop and provide a glycan marker capable of distinguishing histological types of lung cancer. Of serum glycoproteins, glycopeptide and glycoprotein groups whose glycan structures were altered specifically in lung cancer cell culture supernatants were identified, and they are provided as lung cancer differential markers.

摘要翻译： 本发明的目的是开发和提供肺癌鉴别标记物，其可以方便和高度灵敏地诊断肺癌，而不依赖于癌症患者和健康人之间的蛋白质表达水平的增加或降低。 本发明的另一个目的是开发和提供能区分肺癌组织学类型的聚糖标记。 确定了在肺癌细胞培养上清液中特异性改变其聚糖结构的血清糖蛋白，糖肽和糖蛋白，并将其作为肺癌鉴别标记提供。

公开(公告)号：EP2738252A4

公开(公告)日：2015-04-01

申请号：EP12818196

申请日：2012-07-26

申请人： NAT INST OF ADVANCED IND SCIEN

发明人： SOGABE MAKI ,  KUBOTA TOMOMI ,  TOGAYACHI AKIRA ,  IKEHARA YUZURU ,  NARIMATSU HISASHI ,  SAWAKI HIROMICHI ,  NAKANISHI HAYAO ,  NAKANISHI TORU

IPC分类号： C12N15/09 ,  C07K16/30 ,  C07K16/40 ,  C12N5/10 ,  C12N5/16 ,  C12N9/10 ,  C12P21/08 ,  G01N33/573 ,  G01N33/574

CPC分类号： G01N33/57449 ,  C07K16/3069 ,  C07K16/40 ,  C12N5/163

摘要： The present invention provides an antibody capable of specifically recognizing and detecting the highly specific cancer marker with respect to the epithelial ovarian cancer, or a fragment of the antibody. The present invention provides an anti-²1,3-N-acetylglucosaminyltransferase 3 antibody for diagnosis of epithelial ovarian cancer, i.e., an antibody for detection of a glycosyltransferase ²1,3-N-acetylglucosaminyltransferase 3 as an epithelial ovarian cancer marker. The antibody recognizes, as an epitope, a part of a polypeptide of the enzyme consisting of the amino acid sequence represented by SEQ ID NO: 1.

公开(公告)号：EP2884276A4

公开(公告)日：2016-04-20

申请号：EP13827110

申请日：2013-08-09

申请人： NAT INST OF ADVANCED IND SCIEN

发明人： NARIMATSU HISASHI ,  KUNO ATSUSHI ,  IKEHARA YUZURU ,  HASHIMOTO YASUHIRO ,  SHIROTANI KEIRO ,  NARA KIYOMITSU ,  KARIYA YOSHINOBU ,  ITO HIROMI ,  HOSHI KYOKA

IPC分类号： G01N33/53 ,  G01N33/536 ,  G01N33/68

CPC分类号： G01N33/5308 ,  G01N33/536 ,  G01N33/6854 ,  G01N2333/42 ,  G01N2333/4724 ,  G01N2400/00 ,  G01N2440/38 ,  G01N2496/00

摘要： It is intended to develop and provide a method for detecting a particular glycan-isoform rapidly and specifically by a small number of steps. The present invention provides a glycan-isoform detection method comprising quantifying an immune complex formed by the mixing of a test sample with a sugar chain non-reducing terminal residue-binding lectin and an antibody specifically binding to the protein moiety of the glycan-isoform, etc., comparing the obtained amount of the immune complex with the amount of a control immune complex obtained when a control sample is not mixed with the sugar chain non-reducing terminal residue-binding lectin or is mixed with a control protein, and determining the presence or absence of the glycan-isoform of interest in the test sample on the basis of the difference between these amounts.

摘要翻译： 旨在开发并提供一种通过少量步骤快速且具体地检测特定聚糖同种型的方法。 本发明提供了聚糖同种型检测方法，其包括定量由测试样品与糖链非还原末端残基结合凝集素和特异性结合聚糖同种型蛋白质部分的抗体形成的免疫复合物， 将获得的免疫复合物的量与对照样品不与糖链非还原末端残基结合凝集素混合或与对照蛋白混合时获得的对照免疫复合物的量进行比较， 基于这些量之间的差异，在测试样品中存在或不存在感兴趣的聚糖同种型。

公开(公告)号：EP2653476A4

公开(公告)日：2015-10-14

申请号：EP11847931

申请日：2011-12-16

申请人： NAT INST OF ADVANCED IND SCIEN

发明人： NARIMATSU HISASHI ,  HIRABAYASHI JUN ,  KUNO ATSUSHI ,  MATSUZAKI HIDEKI ,  IKEHARA YUZURU ,  ITO HIROMI ,  HASHIMOTO YASUHIRO ,  SHIROTANI KEIRO ,  FUTAKAWA SATOSHI ,  ARAI HAJIME ,  MIYAJIMA MASAKAZU ,  FUJIHARA KAZUO

IPC分类号： C07K1/22 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68

CPC分类号： G01N33/6896 ,  G01N33/6842 ,  G01N2333/47 ,  G01N2333/4728 ,  G01N2400/40 ,  G01N2800/285 ,  H01J49/0036

公开(公告)号：EP2738250A4

公开(公告)日：2015-04-08

申请号：EP12817890

申请日：2012-07-26

申请人： NAT INST OF ADVANCED IND SCIEN

发明人： SOGABE MAKI ,  KUBOTA TOMOMI ,  TOGAYACHI AKIRA ,  IKEHARA YUZURU ,  NARIMATSU HISASHI ,  SAWAKI HIROMICHI ,  NAKANISHI HAYAO ,  NAKANISHI TORU

IPC分类号： C12N15/09 ,  C07K16/40 ,  C12N5/10 ,  C12N9/10 ,  C12P21/08 ,  G01N33/573 ,  G01N33/574

CPC分类号： G01N33/57449 ,  C07K16/40 ,  C07K2317/33 ,  C07K2317/34