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12 条记录 (耗时 0.015 秒)

    NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE
    1.
    发明授权
    NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE 有权
    新CHINUKLIDINDERIVATIVE和它们的药物用途

    公开(公告)号：EP1656375B1

    公开(公告)日：2011-01-19

    申请号：EP04741916.3

    申请日：2004-06-29

    申请人： NeuroSearch A/S ,  ABBOTT LABORATORIES

    发明人： PETERS, Dan ,  OLSEN, Gunnar M. ,  NIELSEN, Elsebet Ostergaard ,  AHRING, Philip K. ,  JORGENSEN, Tino Dyhring ,  SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B.

    IPC分类号： C07D453/02 ,  A61K31/439 ,  A61P25/00

    CPC分类号： C07D453/02

    摘要： This invention relates to novel quinuclidine derivatives represented by Formula (II) wherein represents an optional double bond; n is 1, 2 or 3; X represents a linker selected from -O-, -O-CH2-, -O-CH2-CH2-, -S-, -SO-, -SO2-, -CH2-, -S-CH2-CH2-,-CH2-, -C(=CH2)-, -NH-, -N(alkyl)-, -C(=O)-, -C(=S)-, oo, and ss; and Y represents O, S, SO2, or NR’ wherein R’ represents hydrogen or alkyl and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE
    2.
    发明公开
    NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE 有权
    新CHINUKLIDINDERIVATIVE和它们的药物用途

    公开(公告)号：EP1656375A1

    公开(公告)日：2006-05-17

    申请号：EP04741916.3

    申请日：2004-06-29

    申请人： NEUROSEARCH A/S ,  ABBOTT LABORATORIES

    发明人： PETERS, Dan ,  OLSEN, Gunnar M. ,  NIELSEN, Elsebet Ostergaard ,  AHRING, Philip K. ,  JORGENSEN, Tino Dyhring ,  SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B.

    IPC分类号： C07D453/02 ,  A61K31/439 ,  A61P25/00

    CPC分类号： C07D453/02

    摘要： This invention relates to novel quinuclidine derivatives represented by Formula (II) wherein represents an optional double bond; n is 1, 2 or 3; X represents a linker selected from -O-, -O-CH2-, -O-CH2-CH2-, -S-, -SO-, -SO2-, -CH2-, -S-CH2-CH2-,-CH2-, -C(=CH2)-, -NH-, -N(alkyl)-, -C(=O)-, -C(=S)-, oo, and ss; and Y represents O, S, SO2, or NR’ wherein R’ represents hydrogen or alkyl and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    NOVEL DIAZABICYCLIC ARYL DERIVATIVES
    3.
    发明授权
    NOVEL DIAZABICYCLIC ARYL DERIVATIVES 有权
    NEW二氮杂双环芳基衍生物

    公开(公告)号：EP1599476B1

    公开(公告)日：2009-10-14

    申请号：EP04707948.8

    申请日：2004-02-04

    申请人： NeuroSearch A/S

    发明人： PETERS, Dan ,  OLSEN, Gunnar, M. ,  NIELSEN, Elsebet Ostergaard ,  JORGENSEN, Tino Dyhring ,  AHRING, Philip K.

    IPC分类号： C07D471/08 ,  A61K31/55 ,  A61P25/00

    CPC分类号： C07D471/08

    摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    NOVEL DIAZABICYCLIC ARYL DERIVATIVES
    6.
    发明公开
    NOVEL DIAZABICYCLIC ARYL DERIVATIVES 有权
    NEW二氮杂双环芳基衍生物

    公开(公告)号：EP1599476A1

    公开(公告)日：2005-11-30

    申请号：EP04707948.8

    申请日：2004-02-04

    申请人： NEUROSEARCH A/S

    发明人： PETERS, Dan ,  OLSEN, Gunnar, M. ,  NIELSEN, Elsebet Ostergaard ,  JORGENSEN, Tino Dyhring ,  AHRING, Philip K.

    IPC分类号： C07D471/08 ,  A61K31/55 ,  A61P25/00

    CPC分类号： C07D471/08

    摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    DIAZABICYCLIC BIARYL DERIVATIVES
    8.
    发明授权
    DIAZABICYCLIC BIARYL DERIVATIVES 有权
    双歧杆菌

    公开(公告)号：EP1506200B1

    公开(公告)日：2006-12-20

    申请号：EP03720288.4

    申请日：2003-05-06

    申请人： NEUROSEARCH A/S

    发明人： PETERS, Dan ,  OLSEN, Gunnar M. ,  NIELSEN, Elsebet, Ostergaard ,  JORGENSEN, Tino Dyhring ,  AHRING, Philip K.

    IPC分类号： C07D487/08 ,  A61K31/551 ,  A61P25/04

    CPC分类号： C07D487/08

    摘要： This invention relates to novel diazabicyclic biaryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    NOVEL AZACYCLIC ETHYNYL DERIVATIVES
    9.
    发明公开
    NOVEL AZACYCLIC ETHYNYL DERIVATIVES 有权
    新型的AZACYCLIC ETHYNYL衍生物

    公开(公告)号：EP1506205A2

    公开(公告)日：2005-02-16

    申请号：EP03718655.8

    申请日：2003-05-06

    申请人： NEUROSEARCH A/S

    发明人： PETERS, Dan ,  OLSEN, Gunnar M. ,  NIELSEN, Elsebet Ostergaard ,  JORGENSEN, Tino Dyhring ,  AHRING, Philip K.

    IPC分类号： C07D521/00 ,  C07D451/02 ,  C07D453/02 ,  C07D211/68 ,  A61K31/46 ,  A61K31/439 ,  A61K31/435 ,  A61P25/00

    CPC分类号： C07D451/02 ,  C07D211/70 ,  C07D453/02

    摘要： This invention relates to novel azacyclic ethynyl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的氮杂乙炔基衍生物，其被发现是烟碱乙酰胆碱受体上的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于它们的药理学特征，本发明的化合物可用于疾病或病症等不同的那些涉及到中枢神经系统（CNS），外周神经系统（PNS）的疾病或相关病症的胆碱能系统的治疗有用 平滑肌收缩，内分泌疾病或病症，与神经变性有关的疾病或病症，与炎症相关的疾病或病症，由化学物质滥用终止引起的疼痛和戒断症状。

    NOVEL DIAZABICYCLIC ARYL DERIVATIVES AND THEIR MEDICAL USE
    10.
    发明授权
    NOVEL DIAZABICYCLIC ARYL DERIVATIVES AND THEIR MEDICAL USE 有权
    NEW二氮杂双环芳基衍生物及其医药用途

    公开(公告)号：EP1805183B1

    公开(公告)日：2010-12-29

    申请号：EP05801524.9

    申请日：2005-10-18

    申请人： NeuroSearch A/S

    发明人： PETERS, Dan ,  TIMMERMANN, Daniel B. ,  OLSEN, Gunnar M. ,  NIELSEN, Elsebet Østergaard ,  JORGENSEN, Tino Dyhring

    IPC分类号： C07D487/08 ,  A61P25/00 ,  A61K31/33

    CPC分类号： C07D487/08

    摘要： This invention relates to novel diazabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.