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    NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE
    1.
    发明授权
    NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE 有权
    新CHINUKLIDINDERIVATIVE和它们的药物用途

    公开(公告)号：EP1656375B1

    公开(公告)日：2011-01-19

    申请号：EP04741916.3

    申请日：2004-06-29

    申请人： NeuroSearch A/S ,  ABBOTT LABORATORIES

    发明人： PETERS, Dan ,  OLSEN, Gunnar M. ,  NIELSEN, Elsebet Ostergaard ,  AHRING, Philip K. ,  JORGENSEN, Tino Dyhring ,  SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B.

    IPC分类号： C07D453/02 ,  A61K31/439 ,  A61P25/00

    CPC分类号： C07D453/02

    摘要： This invention relates to novel quinuclidine derivatives represented by Formula (II) wherein represents an optional double bond; n is 1, 2 or 3; X represents a linker selected from -O-, -O-CH2-, -O-CH2-CH2-, -S-, -SO-, -SO2-, -CH2-, -S-CH2-CH2-,-CH2-, -C(=CH2)-, -NH-, -N(alkyl)-, -C(=O)-, -C(=S)-, oo, and ss; and Y represents O, S, SO2, or NR’ wherein R’ represents hydrogen or alkyl and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    NOVEL DIAZABICYCLIC ARYL DERIVATIVES
    4.
    发明公开
    NOVEL DIAZABICYCLIC ARYL DERIVATIVES 有权
    NEW二氮杂双环芳基衍生物

    公开(公告)号：EP1599476A1

    公开(公告)日：2005-11-30

    申请号：EP04707948.8

    申请日：2004-02-04

    申请人： NEUROSEARCH A/S

    发明人： PETERS, Dan ,  OLSEN, Gunnar, M. ,  NIELSEN, Elsebet Ostergaard ,  JORGENSEN, Tino Dyhring ,  AHRING, Philip K.

    IPC分类号： C07D471/08 ,  A61K31/55 ,  A61P25/00

    CPC分类号： C07D471/08

    摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE
    7.
    发明公开
    NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE 有权
    新CHINUKLIDINDERIVATIVE和它们的药物用途

    公开(公告)号：EP1656375A1

    公开(公告)日：2006-05-17

    申请号：EP04741916.3

    申请日：2004-06-29

    申请人： NEUROSEARCH A/S ,  ABBOTT LABORATORIES

    发明人： PETERS, Dan ,  OLSEN, Gunnar M. ,  NIELSEN, Elsebet Ostergaard ,  AHRING, Philip K. ,  JORGENSEN, Tino Dyhring ,  SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B.

    IPC分类号： C07D453/02 ,  A61K31/439 ,  A61P25/00

    CPC分类号： C07D453/02

    摘要： This invention relates to novel quinuclidine derivatives represented by Formula (II) wherein represents an optional double bond; n is 1, 2 or 3; X represents a linker selected from -O-, -O-CH2-, -O-CH2-CH2-, -S-, -SO-, -SO2-, -CH2-, -S-CH2-CH2-,-CH2-, -C(=CH2)-, -NH-, -N(alkyl)-, -C(=O)-, -C(=S)-, oo, and ss; and Y represents O, S, SO2, or NR’ wherein R’ represents hydrogen or alkyl and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    NOVEL DIAZABICYCLIC BIARYL DERIVATIVES
    8.
    发明公开
    NOVEL DIAZABICYCLIC BIARYL DERIVATIVES 有权
    二氮杂双环联芳

    公开(公告)号：EP1506200A2

    公开(公告)日：2005-02-16

    申请号：EP03720288.4

    申请日：2003-05-06

    申请人： NEUROSEARCH A/S

    发明人： PETERS, Dan ,  OLSEN, Gunnar M. ,  NIELSEN, Elsebet, Ostergaard ,  JORGENSEN, Tino Dyhring ,  AHRING, Philip K.

    IPC分类号： C07D487/08 ,  A61K31/551 ,  A61P25/04

    CPC分类号： C07D487/08

    摘要： This invention relates to novel diazabicyclic biaryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    NOVEL DIAZABICYCLIC ARYL DERIVATIVES
    10.
    发明授权
    NOVEL DIAZABICYCLIC ARYL DERIVATIVES 有权
    NEW二氮杂双环芳基衍生物

    公开(公告)号：EP1599476B1

    公开(公告)日：2009-10-14

    申请号：EP04707948.8

    申请日：2004-02-04

    申请人： NeuroSearch A/S

    发明人： PETERS, Dan ,  OLSEN, Gunnar, M. ,  NIELSEN, Elsebet Ostergaard ,  JORGENSEN, Tino Dyhring ,  AHRING, Philip K.

    IPC分类号： C07D471/08 ,  A61K31/55 ,  A61P25/00

    CPC分类号： C07D471/08

    摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.