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1.发明授权
公开(公告)号：EP1656375B1
公开(公告)日：2011-01-19
申请号：EP04741916.3
申请日：2004-06-29
发明人： PETERS, Dan , OLSEN, Gunnar M. , NIELSEN, Elsebet Ostergaard , AHRING, Philip K. , JORGENSEN, Tino Dyhring , SCHRIMPF, Michael, R. , SIPPY, Kevin, B.
IPC分类号： C07D453/02 , A61K31/439 , A61P25/00
CPC分类号： C07D453/02
摘要： This invention relates to novel quinuclidine derivatives represented by Formula (II) wherein represents an optional double bond; n is 1, 2 or 3; X represents a linker selected from -O-, -O-CH2-, -O-CH2-CH2-, -S-, -SO-, -SO2-, -CH2-, -S-CH2-CH2-,-CH2-, -C(=CH2)-, -NH-, -N(alkyl)-, -C(=O)-, -C(=S)-, oo, and ss; and Y represents O, S, SO2, or NR’ wherein R’ represents hydrogen or alkyl and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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2.发明公开
公开(公告)号：EP1656375A1
公开(公告)日：2006-05-17
申请号：EP04741916.3
申请日：2004-06-29
发明人： PETERS, Dan , OLSEN, Gunnar M. , NIELSEN, Elsebet Ostergaard , AHRING, Philip K. , JORGENSEN, Tino Dyhring , SCHRIMPF, Michael, R. , SIPPY, Kevin, B.
IPC分类号： C07D453/02 , A61K31/439 , A61P25/00
CPC分类号： C07D453/02
摘要： This invention relates to novel quinuclidine derivatives represented by Formula (II) wherein represents an optional double bond; n is 1, 2 or 3; X represents a linker selected from -O-, -O-CH2-, -O-CH2-CH2-, -S-, -SO-, -SO2-, -CH2-, -S-CH2-CH2-,-CH2-, -C(=CH2)-, -NH-, -N(alkyl)-, -C(=O)-, -C(=S)-, oo, and ss; and Y represents O, S, SO2, or NR’ wherein R’ represents hydrogen or alkyl and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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公开(公告)号：EP1599476B1
公开(公告)日：2009-10-14
申请号：EP04707948.8
申请日：2004-02-04
申请人： NeuroSearch A/S
发明人： PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet Ostergaard , JORGENSEN, Tino Dyhring , AHRING, Philip K.
IPC分类号： C07D471/08 , A61K31/55 , A61P25/00
CPC分类号： C07D471/08
摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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4.发明授权8-AZA-BICYCLO[3.2.1]OCTANE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 有权8-氮杂二环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的使用
公开(公告)号：EP1594868B1
公开(公告)日：2009-11-11
申请号：EP04709633.4
申请日：2004-02-10
申请人： NeuroSearch A/S
IPC分类号： C07D451/02 , A61K31/46 , A61P25/00
CPC分类号： C07D451/02
摘要： This invention relates to novel 8-aza-bicyclop[3.2. 1 ]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
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5.发明公开DIAZABICYCLIC ARYL DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 有权二氮杂双环芳基衍生物作为烟碱乙酰胆碱受体配体
公开(公告)号：EP1713810A1
公开(公告)日：2006-10-25
申请号：EP05716606.8
申请日：2005-02-01
申请人： NEUROSEARCH A/S
发明人： PETERS, Dan , OLSEN, Gunnar M. , NIELSEN, Elsebet Ostergaard , JORGENSEN, Tino Dyhring , AHRING, Philip K. , TIMMERMANN, Daniel B.
IPC分类号： C07D487/08 , C07D471/08 , A61K31/4995 , A61K31/551 , A61P25/00
CPC分类号： C07D471/08 , C07D487/08
摘要： This invention relates to novel diazabicyclic aryl derivatives represented by Formula (I); which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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公开(公告)号：EP1599476A1
公开(公告)日：2005-11-30
申请号：EP04707948.8
申请日：2004-02-04
申请人： NEUROSEARCH A/S
发明人： PETERS, Dan , OLSEN, Gunnar, M. , NIELSEN, Elsebet Ostergaard , JORGENSEN, Tino Dyhring , AHRING, Philip K.
IPC分类号： C07D471/08 , A61K31/55 , A61P25/00
CPC分类号： C07D471/08
摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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公开(公告)号：EP1175416B1
公开(公告)日：2003-07-16
申请号：EP00920421.5
申请日：2000-04-19
申请人： NEUROSEARCH A/S
IPC分类号： C07D401/04 , C07D403/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14 , A61K31/495 , A61P25/00
CPC分类号： C07D401/14 , C07D401/04 , C07D403/04 , C07D405/14 , C07D417/04
摘要： The present invention relates to novel heteroaryl diazacycloalkane derivatives which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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公开(公告)号：EP1177196A1
公开(公告)日：2002-02-06
申请号：EP00922470.0
申请日：2000-04-27
申请人： NEUROSEARCH A/S
IPC分类号： C07D487/08 , C07D471/08 , A61K31/551 , A61K31/439 , A61K31/395 , A61K49/00 , A61P25/28 , A61P25/30 , A61P29/00
CPC分类号： C07D471/08 , C07D487/08
摘要： The present invention relates to novel heteroaryl diazabicycloalkane derivatives represented by general formula (I), any of its enantiomers or any mixture thereof, an N oxide thereof, a pharmaceutically acceptable salt thereof, in a labelled or un-labelled form, which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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公开(公告)号：EP1175416A1
公开(公告)日：2002-01-30
申请号：EP00920421.5
申请日：2000-04-19
申请人： NEUROSEARCH A/S
IPC分类号： C07D401/04 , C07D403/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14 , A61K31/495 , A61P25/00
CPC分类号： C07D401/14 , C07D401/04 , C07D403/04 , C07D405/14 , C07D417/04
摘要： The present invention relates to novel heteroaryl diazacycloalkane derivatives which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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公开(公告)号：EP1506205B1
公开(公告)日：2008-07-16
申请号：EP03718655.8
申请日：2003-05-06
申请人： NEUROSEARCH A/S
发明人： PETERS, Dan , OLSEN, Gunnar M. , NIELSEN, Elsebet Ostergaard , JORGENSEN, Tino Dyhring , AHRING, Philip K.
IPC分类号： C07D521/00 , C07D451/02 , C07D453/02 , C07D211/68 , A61K31/46 , A61K31/439 , A61K31/435 , A61P25/00
CPC分类号： C07D451/02 , C07D211/70 , C07D453/02
摘要： This invention relates to novel azacyclic ethynyl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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