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公开(公告)号：EP0627416B1
公开(公告)日：1998-05-13
申请号：EP93902553.2
申请日：1993-02-02
发明人： SATO, Fumie 1-219, Kugenumahigashi 3-chome , AMANO, Takehiro Taisho Pharmaceutical Co., Ltd. , KAMEO, Kazuya Taisho Pharmaceutical Co., Ltd. , TANAMI, Tohru Taisho Pharmaceutical Co., Ltd. , MUTOH, Masaru Taisho Pharmaceutical Co., Ltd. , ONO, Naoya Taisho Pharmaceutical Co., Ltd. , GOTO, Jun Taisho Pharmaceutical Co., Ltd.
IPC分类号： C07C405/00 , B01J31/22 , B01J31/24
CPC分类号： B01J31/2404 , B01J31/0237 , B01J31/0267 , B01J31/04 , B01J31/223 , B01J31/2282 , B01J31/2291 , B01J2531/824 , C07C405/00 , Y02P20/55
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公开(公告)号：EP1082961B1
公开(公告)日：2006-01-25
申请号：EP99921249.1
申请日：1999-05-25
发明人： SATO, Fumie , TANAMI, Tohru Taisho Pharmaceutical Co., Ltd. , KAMEO, Kazuya Taisho Pharmaceutical Co., Ltd. , YAMADA, Kenji Taisho Pharmaceutical Co., Ltd. , OKUYAMA, Shigeru Taisho Pharmaceutical Co., Ltd. , ONO, Naoya Taisho Pharmaceutical Co., Ltd.
IPC分类号： A61K31/5575 , A61P25/20
CPC分类号： A61K31/5575 , A61K31/557 , C07C405/00 , Y10S514/923
摘要： A sleep inducing agent comprising, as an active component, a prostaglandin derivative represented by formula (1), wherein X represents a halogen atom, Y represents a group represented by (CH2)m, a cis-vinylene group or a phenylene group, Z represents an ethylene group, a trans-vinylene group, OCH2 or S(O)nCH2, R is a C3-10 cycloalkyl group, a C3-10 cycloalkyl group substituted with a C1-4 alkyl group, a C4-13 cycloalkylalkyl group, a C5-10 alkyl group, a C5-10 alkenyl group, an C5-10 alkynyl group or a bridged cyclic hydrocarbon group, R represents a hydrogen atom, a C1-10 alkyl group or a C3-10 cycloalkyl, m is an integer of 1 to 3, and n is 0, 1 or 2, or a pharmaceutically acceptable salt or hydrate thereof.
摘要翻译： 一种睡眠诱导剂，其含有式（1）所示的前列腺素衍生物作为有效成分，式中，X表示卤素原子，Y表示以（CH2）m表示的基团，顺式 - 亚乙烯基或亚苯基，Z 代表亚乙基，反式 - 亚乙烯基，OCH 2或S（O）n CH 2，R 1是C 3-10环烷基，被C 1-4烷基取代的C 3-10环烷基，C 4-10 环烷基烷基，C 5-10烷基，C 5-10烯基，C 5-10炔基或桥环烃基，R 2表示氢原子，C 1-10烷基或C 3-10 环烷基，m是1至3的整数，并且n是0,1或2，或其药学上可接受的盐或水合物。
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公开(公告)号：EP1082961A1
公开(公告)日：2001-03-14
申请号：EP99921249.1
申请日：1999-05-25
发明人： SATO, Fumie , TANAMI, Tohru Taisho Pharmaceutical Co., Ltd. , KAMEO, Kazuya Taisho Pharmaceutical Co., Ltd. , YAMADA, Kenji Taisho Pharmaceutical Co., Ltd. , OKUYAMA, Shigeru Taisho Pharmaceutical Co., Ltd. , ONO, Naoya Taisho Pharmaceutical Co., Ltd.
IPC分类号： A61K31/557 , C07C405/00
CPC分类号： A61K31/5575 , A61K31/557 , C07C405/00 , Y10S514/923
摘要： A sleep-inducing preparation which comprises as an effective ingredient a prostaglandin derivative represented by the formula:
wherein X is a halogen atom, Y is a group represented by (CH 2 ) m , a cis-vinylene group or a phenylene group, Z is an ethylene group, a trans-vinylene group, OCH 2 or S(O) n CH 2 , R 1 is a C 3-10 cycloalkyl group, a C 3-10 cycloalkyl group substituted with C 1-4 alkyl group(s), a C 4-13 cycloalkylalkyl group, a C 5-10 alkyl group, a C 5-10 alkenyl group, a C 5-10 alkynyl group or a bridged cyclic hydrocarbon group, R 2 is a hydrogen atom, a C 1-10 alkyl group or a C 3-10 cycloalkyl group, m is an integer of 1 to 3, and n is 0, 1 or 2, a pharmaceutically acceptable salt thereof or a hydrate thereof.摘要翻译： 一种睡眠诱导制剂，它含有下式表示的前列腺素衍生物作为有效成分：其中X是卤素原子，Y是由（CH2）m表示的基团，顺式 - 亚乙烯基或亚苯基，Z是 亚乙基，反式 - 亚乙烯基，OCH 2或S（O）n CH 2，R 1为C 3-10环烷基，C 1-4烷基取代的C 3-10环烷基，C 4-13环烷基烷基， C5-10烷基，C5-10链烯基，C5-10炔基或桥环烃基，R2为氢原子，C1-10烷基或C3-10环烷基，m为 整数1至3，并且n是0,1或2，其药学上可接受的盐或其水合物。
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