公开(公告)号：EP1082961B1

公开(公告)日：2006-01-25

申请号：EP99921249.1

申请日：1999-05-25

申请人： TAISHO PHARMACEUTICAL CO., LTD ,  Sato, Fumie

发明人： SATO, Fumie ,  TANAMI, Tohru Taisho Pharmaceutical Co., Ltd. ,  KAMEO, Kazuya Taisho Pharmaceutical Co., Ltd. ,  YAMADA, Kenji Taisho Pharmaceutical Co., Ltd. ,  OKUYAMA, Shigeru Taisho Pharmaceutical Co., Ltd. ,  ONO, Naoya Taisho Pharmaceutical Co., Ltd.

IPC分类号： A61K31/5575 ,  A61P25/20

CPC分类号： A61K31/5575 ,  A61K31/557 ,  C07C405/00 ,  Y10S514/923

摘要： A sleep inducing agent comprising, as an active component, a prostaglandin derivative represented by formula (1), wherein X represents a halogen atom, Y represents a group represented by (CH2)m, a cis-vinylene group or a phenylene group, Z represents an ethylene group, a trans-vinylene group, OCH2 or S(O)nCH2, R is a C3-10 cycloalkyl group, a C3-10 cycloalkyl group substituted with a C1-4 alkyl group, a C4-13 cycloalkylalkyl group, a C5-10 alkyl group, a C5-10 alkenyl group, an C5-10 alkynyl group or a bridged cyclic hydrocarbon group, R represents a hydrogen atom, a C1-10 alkyl group or a C3-10 cycloalkyl, m is an integer of 1 to 3, and n is 0, 1 or 2, or a pharmaceutically acceptable salt or hydrate thereof.

摘要翻译： 一种睡眠诱导剂，其含有式（1）所示的前列腺素衍生物作为有效成分，式中，X表示卤素原子，Y表示以（CH2）m表示的基团，顺式 - 亚乙烯基或亚苯基，Z 代表亚乙基，反式 - 亚乙烯基，OCH 2或S（O）n CH 2，R 1是C 3-10环烷基，被C 1-4烷基取代的C 3-10环烷基，C 4-10 环烷基烷基，C 5-10烷基，C 5-10烯基，C 5-10炔基或桥环烃基，R 2表示氢原子，C 1-10烷基或C 3-10 环烷基，m是1至3的整数，并且n是0,1或2，或其药学上可接受的盐或水合物。

公开(公告)号：EP1082961A1

公开(公告)日：2001-03-14

申请号：EP99921249.1

申请日：1999-05-25

申请人： TAISHO PHARMACEUTICAL CO., LTD ,  Sato, Fumie

发明人： SATO, Fumie ,  TANAMI, Tohru Taisho Pharmaceutical Co., Ltd. ,  KAMEO, Kazuya Taisho Pharmaceutical Co., Ltd. ,  YAMADA, Kenji Taisho Pharmaceutical Co., Ltd. ,  OKUYAMA, Shigeru Taisho Pharmaceutical Co., Ltd. ,  ONO, Naoya Taisho Pharmaceutical Co., Ltd.

IPC分类号： A61K31/557 ,  C07C405/00

CPC分类号： A61K31/5575 ,  A61K31/557 ,  C07C405/00 ,  Y10S514/923

摘要： A sleep-inducing preparation which comprises as an effective ingredient a prostaglandin derivative represented by the formula:
wherein X is a halogen atom, Y is a group represented by (CH 2 ) m , a cis-vinylene group or a phenylene group, Z is an ethylene group, a trans-vinylene group, OCH 2 or S(O) n CH 2 , R 1 is a C 3-10 cycloalkyl group, a C 3-10 cycloalkyl group substituted with C 1-4 alkyl group(s), a C 4-13 cycloalkylalkyl group, a C 5-10 alkyl group, a C 5-10 alkenyl group, a C 5-10 alkynyl group or a bridged cyclic hydrocarbon group, R 2 is a hydrogen atom, a C 1-10 alkyl group or a C 3-10 cycloalkyl group, m is an integer of 1 to 3, and n is 0, 1 or 2, a pharmaceutically acceptable salt thereof or a hydrate thereof.

摘要翻译： 一种睡眠诱导制剂，它含有下式表示的前列腺素衍生物作为有效成分：其中X是卤素原子，Y是由（CH2）m表示的基团，顺式 - 亚乙烯基或亚苯基，Z是 亚乙基，反式 - 亚乙烯基，OCH 2或S（O）n CH 2，R 1为C 3-10环烷基，C 1-4烷基取代的C 3-10环烷基，C 4-13环烷基烷基， C5-10烷基，C5-10链烯基，C5-10炔基或桥环烃基，R2为氢原子，C1-10烷基或C3-10环烷基，m为 整数1至3，并且n是0,1或2，其药学上可接受的盐或其水合物。

公开(公告)号：EP0717990B1

公开(公告)日：2000-05-24

申请号：EP94925636.6

申请日：1994-09-06

申请人： TAISHO PHARMACEUTICAL CO. LTD

发明人： OKUYAMA, Shigeru Taisho Pharmaceutical Co., Ltd. ,  IMAGAWA, Yasuko Taisho Pharmaceutical Co., Ltd. ,  OGAWA, Shinichi Taisho Pharmaceutical Co., Ltd. ,  ARAKI, Hiroaki Taisho Pharmaceutical Co., Ltd. ,  OTOMO, Susumu Taisho Pharmaceutical Co., Ltd.

IPC分类号： A61K31/135 ,  A61K31/40 ,  A61K31/495 ,  A61K31/38

CPC分类号： A61K31/135 ,  A61K31/137

摘要： To provide a remedy for drug dependence which is lowly toxic and has an excellent effect. A composition for remedying drug dependence which contains a phenylalkylamine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof as the active ingredient, wherein X represents halogen, hydroxy or C1-C5 alkoxy; X represents hydrogen, halogen or C1-C5 alkoxy; R and R represent each independently C1-C7 alkyl; R represents phenyl which may be substituted by halogen, hydroxy or C1-C5 alkoxy; and m and n represent each an integer of 2 to 5.

公开(公告)号：EP0717990A1

公开(公告)日：1996-06-26

申请号：EP94925636.6

申请日：1994-09-06

申请人： TAISHO PHARMACEUTICAL CO. LTD

发明人： OKUYAMA, Shigeru Taisho Pharmaceutical Co., Ltd. ,  IMAGAWA, Yasuko Taisho Pharmaceutical Co., Ltd. ,  OGAWA, Shinichi Taisho Pharmaceutical Co., Ltd. ,  ARAKI, Hiroaki Taisho Pharmaceutical Co., Ltd. ,  OTOMO, Susumu Taisho Pharmaceutical Co., Ltd.

IPC分类号： A61K31/135

CPC分类号： A61K31/135 ,  A61K31/137

摘要： Provision of a drug for curing drug dependence which is less toxic and highly effective.
A therapeutic composition for drug dependence which comprises as an active ingredient a phenylalkylamine derivative represented by the formula:

(wherein X¹ is a halogen atom, a hydroxyl group or an alkoxy group having 1 to 5 carbon atoms, X² is a hydrogen atom, a halogen atom or an alkoxy group having 1 to 5 carbon atoms, each of R¹ and R² is an alkyl group having 1 to 7 carbon atoms, R³ is a phenyl group or a substituted phenyl group having as the substituent a halogen atom, a hydroxyl group or an alkoxy group having 1 to 5 carbon atoms, and each of m and n is an integer of 2 to 5) or a pharmaceutically acceptable salt thereof.

摘要翻译： 提供毒品毒性较低的药物依赖药物。 一种用于药物依赖的治疗组合物，其包含作为活性成分的由下式表示的苯基烷基胺衍生物：其中X 1为卤素原子，羟基或具有1至5个碳原子的烷氧基， 2>是氢原子，卤素原子或碳原子数为1〜5的烷氧基，R 1和R 2各自为碳原子数1〜7的烷基，R 3为苯基 基团或具有1〜5个碳原子的羟基或烷氧基作为取代基的取代苯基，m和n分别为2〜5的整数）或其药学上可接受的盐。

公开(公告)号：EP0672413A1

公开(公告)日：1995-09-20

申请号：EP92924891.2

申请日：1992-12-08

申请人： TAISHO PHARMACEUTICAL CO. LTD

发明人： OKUYAMA, Shigeru Taisho Pharmaceutical Co., Ltd. ,  OTOMO, Susumu Taisho Pharmaceutical Co., Ltd. ,  KAWASHIMA, Yutaka Taisho Pharmaceutical Co., Ltd. ,  HATAYAMA, Katsuo Taisho Pharmaceutical Co., Ltd.

IPC分类号： A61K31/435 ,  A61K31/475

CPC分类号： A61K31/475

摘要： To provide novel consciousness disturbance ameliorant and anesthesia antagonist. A consciousness disturbance ameliorant and an anesthesia antagonist both containing (+)-2-nitroxyethyl apovincaminate as the active ingredient.

摘要翻译： 提供新型意识障碍改善剂和麻醉拮抗剂。 意识障碍改善剂和麻醉拮抗剂均含有（+） - 2-硝酰乙基apovincaminate作为活性成分。