利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

5 条记录 (耗时 0.012 秒)

    PROSTAGLANDIN DERIVATIVE, SALT THEREOF, AND USE THEREOF
    4.
    发明公开
    PROSTAGLANDIN DERIVATIVE, SALT THEREOF, AND USE THEREOF 失效
    PROSTAGLANDIN-DERIVATE，IHRE SALZE UND IHRE VERWENDUNG

    公开(公告)号：EP0737676A1

    公开(公告)日：1996-10-16

    申请号：EP95904003.1

    申请日：1994-12-27

    申请人： TAISHO PHARMACEUTICAL CO. LTD

    发明人： SATO, Fumie 1-219, Kugenumahigashi 3-chome ,  AMANO, Takehiro Taisho Pharmaceutical Co., Ltd. ,  KAMEO, Kazuya Taisho Pharmaceutical Co., Ltd. ,  TANAMI, Tohru Taisho Pharmaceutical Co., Ltd. ,  MUTOH, Masaru Taisho Pharmaceutical Co., Ltd. ,  ONO, Naoya Taisho Pharmaceutical Co., Ltd. ,  GOTO, Jun Taisho Pharmaceutical Co., Ltd.

    IPC分类号： C07C405/00 ,  A61K31/557

    CPC分类号： C07C405/0033

    摘要： Prostaglandin derivative represented by Formula (I):
    wherein R 1 is a hydrogen atom, an alkyl group having 1 to 10 carbon atoms or a cycloalkyl group having 3 to 10 carbon atoms, and R 2 is a cycloalkyl group having 3 to 10 carbon atoms, a cycloalkyl group having 3 to 10 carbon atoms substituted by a methyl group, an alkyl group having 1 to 3 carbon atoms substituted by a cycloalkyl group having 3 to 10 carbon atoms, a branched alkyl group having 5 to 10 carbon atoms or a branched alkenyl group having 5 to 10 carbon atoms, X is a halogen atom substituted at the α- or β-configuration, and A is an ethylene group, a vinylene group or an ethynylene group, salts thereof, and a pharmaceutical composition for lowering intraocular pressure containing them as an effective ingredient.
    These compounds are useful as lowering agents of intraocular pressure with no or remarkably reduced side-effects such as transient ocular hypertension and the like.

    摘要翻译： 式（I）表示的前列腺素衍生物：其中R 1为氢原子，碳原子数1〜10的烷基或碳原子数3〜10的环烷基，R 2为环烷基 具有3至10个碳原子的基团，被甲基取代的具有3至10个碳原子的环烷基，被3至10个碳原子的环烷基取代的具有1至3个碳原子的烷基，具有5个碳原子的支链烷基 至10个碳原子或具有5至10个碳原子的支链烯基，X是以α或β-构型取代的卤素原子，A是亚乙基，亚乙烯基或亚乙炔基，其盐，和 用于降低含有它们的眼内压作为有效成分的药物组合物。 这些化合物可用作眼内压降低剂，没有或显着降低副作用，例如暂时性高眼压等。