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公开(公告)号：EP0350915B1
公开(公告)日：1994-05-11
申请号：EP89112844.9
申请日：1989-07-13
CPC分类号： C07K5/0825 , C07K5/0819 , Y02P20/55
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公开(公告)号：EP0155825A3
公开(公告)日：1986-09-17
申请号：EP85301793
申请日：1985-03-14
CPC分类号： C12Q1/46 , C12Q2334/00
摘要： This invention relates to novel choline derivatives 3,4-dihydroxybenzoylcholine halides of the formula
wherein X represents a halogen atom. The novel choline derivatives are of great use as a substrate in the assay of enzymatic activity of cholinesterase.摘要翻译： 本发明涉及式（CHEM）的新型胆碱衍生物3,4-二羟基苯甲酰胆碱卤化物，其中X代表卤素原子。 胆碱酯酶的酶活性测定中，胆碱衍生物作为底物是非常有用的。
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3.发明公开Novel substrates for use in measuring the concentration of kallikrein in urine 失效基材用于确定Harnkallikrein的浓度使用。
公开(公告)号：EP0167980A2
公开(公告)日：1986-01-15
申请号：EP85108241.2
申请日：1985-07-03
CPC分类号： C07K5/0821 , C07K5/0806 , C07K5/0808 , C12Q1/37 , C12Q2334/10 , G01N2333/96455 , Y10S435/81 , Y10S530/802
摘要： A novel chromogenic and fluorescent substrate for measuring the concentration of kallikrein in urine. The novel substrate according to the present invention has very excellent substrate specificity to kallikreins and good solubility In water or biological test solutions.
The present substrate is therefore useful for measuring the concentration of kallikrein in urine for the diagnosis of hypertension and other diseases caused by the lowering of the concentration of kallikrein.-
公开(公告)号：EP0077124A1
公开(公告)日：1983-04-20
申请号：EP82304589.3
申请日：1982-09-01
CPC分类号： C07K5/0808 , C07K5/0806 , C07K5/0815 , C07K5/0819 , C12Q1/37 , C12Q2337/10 , C12Q2337/12 , G01N2333/968
摘要： A novel substrate for measuring plasmin which has chromophoric and fluoroescent properties against plasmin or a plasmin-like enzyme, which is characterized by being a compound of the formula or a salt thereof:
wherein m=1,2,3or4
wherein摘要翻译： 一种测定纤溶酶的新型底物，它具有针对纤溶酶或纤溶酶样酶的发色和荧光特性，其特征为具有下式的化合物或其盐：其中m = 1,2,3或4，其中
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公开(公告)号：EP0882800A3
公开(公告)日：2000-06-07
申请号：EP98110059.7
申请日：1998-06-03
IPC分类号： C12Q1/26
CPC分类号： C12Q1/26 , Y10S435/961
摘要： There is provided a method for determination of direct bilirubin which comprises the steps of contacting a bilirubin oxidase with a sample suspected of containing bilirubin; and, measuring direct bilirubin in the sample by optical changes of the sample, characterized in that bilirubin oxidase is allowed to act in the presence of a indirect bilirubin reaction inhibitor selected from a thiocyanate ion, a hydrazide, reduced nicotinamide adenine dinucleotide, reduced nicotinamide adenine dinucleotide phosphate and a potassium ion of 100 mM to 800 mM. By completely avoiding interference of indirect bilirubin, direct bilirubin is selectively and precisely determined using a reagent kit in the form of solution. The method and reagent of the invention are safe and free of environmental pollution due to unnecessary waste liquid treatment.
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6.发明公开
公开(公告)号：EP0513863A1
公开(公告)日：1992-11-19
申请号：EP92113199.1
申请日：1989-06-14
发明人： Kuroiwa, Katsumasa , Matsuura, Hitoshi , Katayama, Katsuhiro , Nakatsuyama, Shuichi , Nagasawa, Takeshi , Endo, Koji
IPC分类号： C07K5/08 , C07C279/14 , C12Q1/37
CPC分类号： C07K5/0205 , C07K5/0819 , C07K5/0825
摘要： Novel compounds represented by the following formula:
wherein A and B each represents a specific amino acid residue are excellent as substrates for determination of enzyme activity such as trypsin, etc. The compounds can be synthesized from novel arginyl-3-tert-alkyloxycarbonyl-4-nitroanilides.摘要翻译： 由下式表示的新化合物：
worin A和B各自darstellt一个特定氨基酸残基是优异的作为底物用于测定酶活性：例如胰蛋白酶，等等。这些化合物可以从新颖精氨酰-3-叔来合成 烷氧基羰基-4- nitroanilides。 -
7.发明公开
公开(公告)号：EP0347734A2
公开(公告)日：1989-12-27
申请号：EP89110781.5
申请日：1989-06-14
发明人： Kuroiwa, Katsumasa , Matsuura, Hitoshi , Katayama, Katsuhiro , Nakatsuyama, Shuichi , Nagasawa, Takeshi , Endo, Koji
CPC分类号： C07K5/0205 , C07K5/0819 , C07K5/0825
摘要： Novel compounds represented by the following formula:
wherein A and B each represents a specific amino acid residue and X represents hydrogen or a specific substituent, are excellent as substrates for determination of enzyme activity such as trypsin, etc. The compounds can be synthesized from novel arginyl-3-tert-alkyloxycarbonyl-4-nitroanilides.摘要翻译： 由下式表示的新化合物：
worin A和B各自darstellt特定氨基酸残基，X darstellt氢或特定的取代基，是优异的作为底物用于测定酶活性：例如胰蛋白酶，等等。这些化合物可以是 从新颖精氨酰3-叔烷氧基羰基-4- nitroanilides合成。 -
公开(公告)号：EP0160980A2
公开(公告)日：1985-11-13
申请号：EP85105635.8
申请日：1985-05-08
IPC分类号： C12Q1/46
CPC分类号： C12Q1/46 , C12Q2334/00
摘要： In a method for determining cholinesterase (hereinafter referred to as ChE) activity, the improvement comprising by using, as a substrate, a protocatechuoylcholine derivative represented by the general formula (I),
(wherein X is a halogen atom).
The method for determining ChE activity according to the present invention is free from defects of the conventional methods, has many advantages and characteristics, permits accurate and simple determination of ChE activity, and can sufficiently contribute to determination of ChE activity in daily clinical examinations.-
公开(公告)号：EP0076042B1
公开(公告)日：1985-04-10
申请号：EP82304588.5
申请日：1982-09-01
CPC分类号： C07K5/0804 , C07K5/0812 , C12Q1/56 , C12Q2337/10 , G01N2333/974
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公开(公告)号：EP0076042A1
公开(公告)日：1983-04-06
申请号：EP82304588.5
申请日：1982-09-01
CPC分类号： C07K5/0804 , C07K5/0812 , C12Q1/56 , C12Q2337/10 , G01N2333/974
摘要： A novel substrate for measuring thrombin which has chromophoric and fluorescent properties on thrombin or a thrombin-like enzymes and is represented by a compound of the following general formula or a salt thereof:
wherein R represents
or
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