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1.发明公开PYRROLO 2,1,5-CD]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES 失效预防或治疗雌激素依赖的疾病的吡咯并[2.1.5 CD]吲衍生物的
公开(公告)号：EP0986560A1
公开(公告)日：2000-03-22
申请号：EP98924067.6
申请日：1998-06-02
申请人： NOVO NORDISK A/S , KARO BIO AB
发明人： JORGENSEN, Anker, Steen , JACOBSEN, Poul , CHRISTIANSEN, Lise, Brown , BURY, Paul, Stanley , KANSTRUP, Anders
IPC分类号： C07D471/16 , A61K31/44
CPC分类号： C07D471/16
摘要： The present invention relates to therapeutically active compounds of formula (I), a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estrogen related diseases or syndromes.
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2.发明公开NOVEL VINYL N-(2-BENZOYLPHENYL)-L-TYROSINE DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC 审中-公开新型乙烯基N-（2-苯甲酰基苯基）-L-酪氨酸衍生物及其作为抗糖尿病药物等的用途
公开(公告)号：EP1414785A1
公开(公告)日：2004-05-06
申请号：EP02745185.5
申请日：2002-07-05
申请人： NOVO NORDISK A/S
发明人： JEPPESEN, Lone , BURY, Paul, Stanley , MOGENSEN, John, Patrick , PETTERSSON, Ingrid , SAUERBERG, Per
IPC分类号： C07C229/36 , C07D215/04 , A61K31/198 , A61K31/216 , A61P1/18 , A61P3/06 , A61P3/10
CPC分类号： C07D215/14 , C07C229/36 , C07C2603/18
摘要： Novel compounds of general formula (I), the use of these compounds as medicaments, pharmaceuticaly compositions comprising the compounds and methods of treatment employing these compounds and compostiones. The present compounds may be useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR). The compounds exert their effects by modulating the PPAR response in a partial agonist manner.
摘要翻译： 通式（I）的新型化合物，这些化合物作为药物的用途，包含所述化合物的药物组合物以及使用这些化合物和组合物的治疗方法。 本发明化合物可用于治疗和/或预防由核受体介导的病症，特别是过氧化物酶体增殖物激活受体（PPAR）。 这些化合物通过以部分激动剂的方式调节PPAR应答来发挥它们的作用。
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3.发明公开PROPIONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF DIABETES AND OBESITY 审中-公开在德意志帝国大学医学院附属医院
公开(公告)号：EP1254101A1
公开(公告)日：2002-11-06
申请号：EP01946844.6
申请日：2001-01-26
申请人： Novo Nordisk A/S
发明人： MOGENSEN, John, Patrick , SAUERBERG, Per , BURY, Paul, Stanley , JEPPESEN, Lone , PETTERSSON, Ingrid
IPC分类号： C07C69/708 , C07C59/64 , C07D213/55 , C07D307/80 , C07D317/54 , C07D215/14 , C07D307/40 , A61K31/435 , A61K31/34 , A61K31/357 , A61P3/04 , A61P3/10
CPC分类号： C07D213/30 , A61K31/34 , A61K31/357 , A61K31/435 , A61K45/06 , C07C59/68 , C07C59/72 , C07C59/90 , C07C69/734 , C07C69/76 , C07C2603/18 , C07C2603/26 , C07D215/14 , C07D307/42 , C07D307/79 , C07D307/80 , C07D317/54 , A61K2300/00
摘要： The present invention relates to compounds of general formula (I). The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).
摘要翻译： 本发明涉及通式（I）的化合物。 该化合物可用于治疗和/或预防由核受体介导的病症，特别是过氧化物酶体增殖物激活受体（PPAR）。
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公开(公告)号：EP0937061A1
公开(公告)日：1999-08-25
申请号：EP97910265.0
申请日：1997-10-28
申请人： NOVO NORDISK A/S
发明人： JACOBSEN, Poul , TREPPENDAHL, Svend , BURY, Paul, Stanley , KANSTRUP, Anders , CHRISTIANSEN, Lise, Brown
CPC分类号： C07D311/58
摘要： The present invention relates to therapeutically active compounds of formula (I), a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estrogen related diseases or syndromes.
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公开(公告)号：EP0937058A1
公开(公告)日：1999-08-25
申请号：EP97909217.0
申请日：1997-10-28
申请人： NOVO NORDISK A/S
发明人： JACOBSEN, Poul , TREPPENDAHL, Svend , BURY, Paul, Stanley , KANSTRUP, Anders , CHRISTIANSEN, Lise, Brown
CPC分类号： C07D413/04 , C07D311/58
摘要： The present invention relates to therapeutically active compounds of formula (I), a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estrogen related diseases or syndromes.
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6.发明公开NOVEL (-)-ENANTIOMERS OF CIS-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES 失效（ - ） - 顺式-3,4-苯并二氢吡喃的对映异构体，以防止或治疗OESTROGENBEZOGENEN疾病或综合征
公开(公告)号：EP0937057A1
公开(公告)日：1999-08-25
申请号：EP97909215.0
申请日：1997-10-28
申请人： NOVO NORDISK A/S
发明人： JACOBSEN, Paul , TREPPENDAHL, Svend , BURY, Paul, Stanley , KANSTRUP, Anders , CHRISTIANSEN, Lise, Brown
CPC分类号： C07D311/74
摘要： The present invention relates to therapeutically active compounds of formula (I), a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estrogen related diseases or syndromes.
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7.发明公开NOVEL VINYL CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC. 审中-公开NEUE VINYLKARBONSÄURENDERIVATE UNDER IHRE VERWENDUNG ALS ANTIDIABETIKA
公开(公告)号：EP1414778A1
公开(公告)日：2004-05-06
申请号：EP02745186.3
申请日：2002-07-05
申请人： NOVO NORDISK A/S
发明人： JEPPESEN, Lone , BURY, Paul, Stanley , MOGENSEN, John, Patrick , PETTERSSON, Ingrid , SAUERBERG, Per
IPC分类号： C07C59/58 , C07C69/734 , A61K31/192 , A61K31/216 , A61P1/18 , A61P3/06 , A61P3/10
CPC分类号： C07D307/42 , C07C59/58 , C07C69/734 , C07C255/54 , C07C2603/18 , C07D277/24 , C07D333/16
摘要： Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPARδ suptype.
摘要翻译： 新的通式（I）化合物，这些化合物作为药物组合物的用途，包含该化合物的药物组合物和使用这些化合物和组合物的治疗方法。 本发明化合物可用于治疗和/或预防由过氧化物酶体增殖物激活受体（PPAR）介导的病症，特别是PPARδ超型。
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公开(公告)号：EP1171438A1
公开(公告)日：2002-01-16
申请号：EP00918726.1
申请日：2000-04-17
申请人： NOVO NORDISK A/S
IPC分类号： C07D471/04 , C07D223/22 , A61K31/437 , A61K31/55 , A61P3/10 , A61P3/04
CPC分类号： C07D471/04 , C07D223/22
摘要： The present invention relates to compounds of general formula (I). The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).
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9.发明公开NOVEL $i(CIS)-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES 失效（+） - -i的对映异构体（CIS）-3,4-苯并二氢吡喃FOR疾病预防或治疗或综合征OESTROGENBEZOGENEN
公开(公告)号：EP0937062A1
公开(公告)日：1999-08-25
申请号：EP97910267.0
申请日：1997-10-28
申请人： NOVO NORDISK A/S
发明人： JACOBSEN, Poul , TREPPENDAHL, Svend , BURY, Paul, Stanley , KANSTRUP, Anders , CHRISTIANSEN, Lise, Brown
CPC分类号： C07D311/74
摘要： The present invention relates to therapeutically active compounds of formula (I), a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estrogen related diseases or syndromes.
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10.发明公开NOVEL $i(CIS)-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES 失效-i（CIS）-3,4-苯并二氢吡喃，以防止或治疗OESTROGENBEZOGENEN疾病或综合征
公开(公告)号：EP0934299A1
公开(公告)日：1999-08-11
申请号：EP97910266.0
申请日：1997-10-28
申请人： NOVO NORDISK A/S
发明人： JACOBSEN, Poul , TREPPENDAHL, Svend , BURY, Paul, Stanley , KANSTRUP, Anders , CHRISTIANSEN, Lise, Brown
CPC分类号： C07D311/58
摘要： The present invention relates to therapeutically active compounds of formula (I), a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estrogen related diseases or syndromes.
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