公开(公告)号：EP0990168A1

公开(公告)日：2000-04-05

申请号：EP98930914.1

申请日：1998-06-19

申请人： NYCOMED IMAGING AS

发明人： ARDENKJAER-LARSEN, Jan, HenrikNycomed Imaging AS ,  GOLMAN, KlaesNycomed Imaging AS ,  HANSSON, GeorgNycomed Imaging AS ,  LEUNBACH, IbNycomed Imaging AS ,  PETERSSON, StefanNycomed Imaging AS ,  WISTRAND, Lars-GoranNycomed Imaging AS ,  AXELSSON, OskarNycomed Imaging AS

IPC分类号： G01R33/28 ,  G01R33/62 ,  A61K49/00

CPC分类号： A61K49/10 ,  A61K49/08 ,  A61K49/18 ,  A61K49/20 ,  G01R33/5601 ,  G01R33/62

摘要： This invention provides a method of MR investigation of a sample, said method comprising: (i) placing in a uniform magnetic field a composition comprising an OMRI contrast agent and an MR imaging agent containing nuclei (MR imaging nuclei) capable of emitting magnetic resonance signals (e.g. the primary magnetic field B0) and capable of exhibiting a T1 relaxation time of 6s or more (at 37 °C in D20 in a field of 7T); (ii) exposing said composition to a first radiation of a frequency selected to excite electron spin transitions in said OMRI contrast agent; (iii) optionally but preferably separating the whole, substantially the whole, or a portion of said OMRI contrast agent from said MR imaging agent; (iv) administering said MR imaging agent to said sample; (v) exposing said sample to a second radiation of a frequency selected to excite nuclear spin transitions; (vi) detecting magnetic resonance signals from said sample; and (vii) optionally, generating an image or dynamic flow data from said detected signals.