公开(公告)号：EP0998518A1

公开(公告)日：2000-05-10

申请号：EP98936508.5

申请日：1998-07-24

申请人： NYCOMED IMAGING AS

发明人： SAINDANE, Manohar, Tukaram ,  LADD, David, Lee

IPC分类号： C08G65/32 ,  C07F9/09

CPC分类号： C08G65/3353 ,  C07F9/091 ,  C08G65/322

摘要： The invention provides an improved process for the synthesis of compounds carrying at least one phosphate group, especially polyalkylene glycol phosphate compounds, said process comprising the steps of: (a) reacting a compound containing at least one primary alcohol moiety with a diaryl- or diaralkyl- halophosphate whereby to form the corresponding diaryl- or diaralkyl-phosphate ester; (b) reductively cleaving the resulting product; and (c) if desired, repeating steps (a) and (b) with the product of step (b) whereby to produce a compound carrying two or more phosphate groups. Advantages of the process in accordance with the invention are that this avoids the production of by-products and results in products which are low in impurities. Also provided are novel diaryl- and diaralkyl-phosphate ester compounds, in particular polyethylene glycol diphenylphosphate ester and derivatives thereof.

摘要翻译： 本发明提供了用于合成携带至少一个磷酸酯基团的化合物，尤其是聚亚烷基二醇磷酸酯化合物的改进方法，所述方法包括以下步骤：（a）使含有至少一个伯醇部分的化合物与二芳基或二芳基 - 卤代磷酸酯，从而形成相应的二芳基或二芳基磷酸酯; （b）还原性裂解所得产物; 和（c）如果需要，用步骤（b）的产物重复步骤（a）和（b），由此产生携带两个或多个磷酸酯基团的化合物。 根据本发明的方法的优点在于，这避免了副产物的产生并导致杂质含量低的产物。 还提供了新的二芳基磷酸酯和二芳基磷酸酯化合物，特别是聚乙二醇二苯基磷酸酯及其衍生物。