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公开(公告)号：EP0831930A1
公开(公告)日：1998-04-01
申请号：EP96919953.0
申请日：1996-06-03
申请人： NYCOMED IMAGING AS
发明人： HOLLISTER, Kenneth, Robert , KELLER, Kenneth, Edmond , WEI, Dong , PENG, Xin , LADD, David, Lee , SNOW, Robert, Allen
CPC分类号： A61K49/128
摘要： The invention provides polymeric polychelants containing polymer repeat units of the formula [L-Ch-L-B] (where Ch is a polydentate chelant moiety; L is an amide or ester linkage; B is a hydrophobic group providing a carbon chain of at least 4 carbon atoms between the L linkages it interconnects) or a salt or chelate thereof, with the proviso that where Ch is 2,5-biscarboxymethyl-2,5-diazahex-1,6-diyl, the polychelant is metallated with lanthanide or manganese ions or B provides a carbon chain of at least 10 carbon atoms between the L linkages it interconnects and their salts and chelates. The paramagnetic polychelates of the polychelants of the invention have remarkably high R1 relaxivities.
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公开(公告)号：EP0996469A1
公开(公告)日：2000-05-03
申请号：EP98930870.5
申请日：1998-06-16
发明人： HENRICHS, Paul, Mark , ERIKSEN, Marten , RONGVED, P l , GUNTHER, Wolfgang, Hans, Heinrich , SNOW, Robert, Allen , HOLLISTER, Kenneth, Robert , MCINTIRE, Gregory, Lynn
IPC分类号： A61K49/00
CPC分类号： A61K41/00 , A61B6/508 , A61K49/00 , A61K49/0002 , A61K49/0034 , A61K49/0078 , A61K49/0084 , A61K49/0091 , A61K49/0404 , A61K49/0438 , A61K49/0466 , Y10S977/949
摘要： The invention relates to a method of generating an image of an animate human or non-human animal body or part thereof. The method comprises administering to said body a physiologically tolerable contrast agent comprising a radiation absorbing component and/or a pressure inducing component, exposing said body to radiation, detecting pressure waves generated in said body by said radiation and generating an optoacoustic image therefrom of at least a part of said body containing the administered contrast agent.
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