公开(公告)号：EP3350192B1

公开(公告)日：2019-08-07

申请号：EP16787487.4

申请日：2016-09-15

申请人： Nanomedsyn ,  Centre National de la Recherche Scientifique ,  Université de Montpellier

发明人： MORERE, Alain ,  DA SILVA, Afitz ,  BOUFFARD, Elise ,  EL CHEIKH, Khaled ,  DURAND, Jean-Olivier ,  MAYNADIER, Marie ,  BASILE, Ilaria

IPC分类号： C07H15/04 ,  A61K31/7028 ,  A61P35/00

公开(公告)号：EP3350192A1

公开(公告)日：2018-07-25

申请号：EP16787487.4

申请日：2016-09-15

申请人： Nanomedsyn ,  Centre National de la Recherche Scientifique ,  Université de Montpellier

发明人： MORERE, Alain ,  DA SILVA, Afitz ,  BOUFFARD, Elise ,  EL CHEIKH, Khaled ,  DURAND, Jean-Olivier ,  MAYNADIER, Marie ,  BASILE, Ilaria

IPC分类号： C07H15/04 ,  A61K31/7028 ,  A61P35/00

CPC分类号： C07H15/04 ,  A61K38/47 ,  A61K41/0057 ,  A61K47/26 ,  A61K47/6929 ,  A61K49/0036 ,  A61K49/0093 ,  C07H15/18 ,  C07H15/26 ,  C12N9/2402 ,  C12N9/96 ,  C12Y302/0102

摘要： The subject matter of the present invention is a compound characterized in that it has the general formula (I): in which P
1 , X, n, A, L and L
1 are as defined in Claim 1. The present invention also relates to a process for preparing said compounds (I) and to the use thereof for targeting the cation-independent mannose 6-phosphate receptor (CI-M6PR). The subject matter of the invention is also a conjugate of formula (III): in which P
1 , X, n, A, L and L'
1 are as defined in Claim 6, and the use thereof: - in a method for therapeutic treatment of the human or animal body, in particular chosen from enzyme replacement therapy, photodynamic therapy or cancer treatment, and/or - in a method of diagnosis, in particular of diseases or of ailments associated with an increase or with a decrease in CI-M6PR expression.

公开(公告)号：EP3097209A1

公开(公告)日：2016-11-30

申请号：EP15704352.2

申请日：2015-01-22

申请人： Centre National de la Recherche Scientifique (C.N.R.S.) ,  Université de Montpellier 1 ,  Centre Hospitalier Universitaire De Toulouse

发明人： GARCIA, Marcel ,  VAILLANT, Ophélie ,  REBILLARD, Xavier ,  MAZEROLLES, Catherine ,  GARY-BOBO, Magali ,  MORERE, Alain

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C07K16/2863 ,  C07K16/3069 ,  C12Q2600/158 ,  G01N33/57434

摘要： The invention relates to a method for the
in vitro diagnosis of prostate cancer in a patient, characterised in that it comprises a step of measuring the expression level of the gene of the cation-independent mannose-6-phosphate receptor (CI-M6PR) in a sample of prostate tissue of the patient, the determination of overexpression of said CI-M6PR gene indicating the presence of prostate cancer in said patient.

摘要翻译： 本发明涉及一种用于体外诊断患者前列腺癌的方法，其特征在于其包括测量阳离子非依赖性甘露糖-6-磷酸受体（CI-M6PR）基因的表达水平的步骤 所述患者的前列腺组织的样品，所述CI-M6PR基因过表达的测定表明所述患者中存在前列腺癌。

公开(公告)号：EP2513083A1

公开(公告)日：2012-10-24

申请号：EP10790539.0

申请日：2010-12-07

申请人： CNRS Centre National de la Recherche Scientifique ,  Universite Rennes 1 ,  INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Université Montpellier 2 Sciences et Techniques

发明人： BREVET, David ,  RAEHM, Laurence ,  BLANCHARD-DESCE, Mireille ,  MONGIN, Olivier ,  GARY-BOBO-SABLE-TEYCHENE, Magali ,  GARCIA, Marcel ,  MORERE, Alain ,  DURAND, Jean-Olivier

IPC分类号： C07D333/16 ,  C07D333/20 ,  C07D495/04 ,  A61K41/00 ,  A61K47/48 ,  A61P35/00

CPC分类号： C07F7/1836 ,  B82Y30/00 ,  C07D333/16 ,  C07D333/20 ,  C07D409/10 ,  C07D495/04 ,  C07F7/0801 ,  C07F7/10 ,  C07H23/00

摘要： The invention relates to compounds of formula (I) : the groups A and B represent independently from each other -CH=CH-, or -C≡C-, the terms t, u, v, w represent, independently from each other, values ranging from 0 to 9, the groups Y
1 and Y
2 can represent independently from each other an alkyl group (linear, branched or substituted) carrying from 1 to 9 carbon atoms, the groups Z
1 , Z
2 , Z
3 , and Z
4 can represent independently from each other a chemically reactive group W, such as OH, NH
2 , SH, the groups Z
5 and Z
6 represent independently from each other a hydrogen atom, silica nanoparticles functionalized by these compounds, and their use as drugs.

公开(公告)号：EP2448600A1

公开(公告)日：2012-05-09

申请号：EP10727003.5

申请日：2010-07-02

申请人： INSERM - Institut National de la Santé et de la Recherche Médicale ,  Centre National de la Recherche Scientifique CNRS ,  Universite De Montpellier 1 ,  Université Montpellier 2 Sciences et Techniques

发明人： GARCIA, Marcel ,  MORERE, Alain ,  GARY-BOBO, Magali ,  CERUTTI, Martine ,  EL CHEIKH, Khaled ,  BASILE, Ilaria ,  NIRDE, Philippe

IPC分类号： A61K47/48 ,  A61P43/00

CPC分类号： A61K47/48092 ,  A61K47/549

摘要： The invention relates to conjugates of products of interest and of compounds targeting the cation-independent mannose 6-phosphate receptor with a high affinity. The invention also relates to their applications, for instance in enzyme replacement therapies.

公开(公告)号：EP2445874B1

公开(公告)日：2017-11-29

申请号：EP10726102.6

申请日：2010-06-24

申请人： Centre National de la Recherche Scientifique (C.N.R.S.) ,  Université Montpellier 2 Sciences et Techniques

发明人： MORERE, Alain ,  MENUT, Chantal ,  GUNATA, Yusuf Ziya ,  AGREBI, Abdelhamid

IPC分类号： C07D207/20 ,  C07D211/70

CPC分类号： C07D211/70 ,  C07D207/20

公开(公告)号：EP2831081A1

公开(公告)日：2015-02-04

申请号：EP13716977.7

申请日：2013-03-26

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Université Montpellier 2, Sciences et Techniques ,  The Regents of the University of California ,  Ecole Nationale Supérieure de Chimie de Montpellier

发明人： CUNIN, Frédérique ,  DURAND, Jean-Olivier ,  SAILOR, Michael J. ,  GARCIA, Marcel ,  SECRET, Emilie ,  GARY-BOBO, Magali ,  MAYNADIER, Marie ,  MORERE, Alain

IPC分类号： C07D487/22 ,  A61K31/409 ,  A61K41/00 ,  H01L51/00

CPC分类号： A61K41/0071 ,  A61K31/28 ,  A61K31/315 ,  A61K31/409 ,  A61K41/008 ,  A61N5/062 ,  C09B47/00 ,  Y10T428/2982

摘要： The invention relates to nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by means of photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by means of excitation in the near-infrared region (> 600 nm) in monophotonic and biphotonic modes. According to the invention, in formula (I), (AA) is a porous silicon nanoparticle.

公开(公告)号：EP2445874A1

公开(公告)日：2012-05-02

申请号：EP10726102.6

申请日：2010-06-24

申请人： Centre National de la Recherche Scientifique CNRS ,  Université Montpellier 2 Sciences et Techniques

发明人： MORERE, Alain ,  MENUT, Chantal ,  GUNATA, Yusuf Ziya ,  AGREBI, Abdelhamid

IPC分类号： C07D207/20 ,  C07D211/70

CPC分类号： C07D211/70 ,  C07D207/20

摘要： The present invention relates to a method for synthesising a compound of the following formula (I), where R is a methyl or ethyl group, n is 1 or 2, and X is a CH
2 or CD
2 group, from a compound of the following formula (II), where R and n are as defined above. The invention also relates to a method for assaying the compounds of formula (I) using a corresponding deuterated derivative as an internal reference, as well as to the use of ketal derivatives of compounds of formula (I) as a stable precursor, in particular in a flavouring composition.

摘要翻译： 本发明涉及一种用于synthetizing下述式（I）的化合物：worin R是甲基或乙基，n是1或2，并且X是CH 2或CD2组，由下式的化合物 （II）：worin R和n如上所定义，并且因此涉及一种用于使用相应的氘化衍生物的式（I）化合物测定作为内部参考，以及所述化合物的用途，缩酮衍生物的 在调味组合物中的式（I），其为稳定的前体，在particulare。

公开(公告)号：EP2346875A1

公开(公告)日：2011-07-27

申请号：EP09741323.1

申请日：2009-09-14

申请人： Centre National de la Recherche Scientifique ,  Institut Curie ,  Université Montpellier II ,  Université Mouloud Mammeri

发明人： BREVET, David ,  HOCINE, Ouahiba ,  DURAND, Jean-Olivier ,  MAILLARD, Philippe ,  MORERE, Alain ,  GARCIA, Marcel ,  SMAÏHI, Monique ,  GARY-BOBO, Magali

IPC分类号： C07D487/22 ,  A61K31/409 ,  A61P35/00

CPC分类号： C07D487/22

摘要： Nanovectors are disclosed that make it possible to simultaneously target, image, and treat cancerous cells using photodynamic therapy. Also disclosed are novel molecules (I) derived from porphyrins, silica-based nanoparticles comprising the same, and their use in photodynamic therapy.

公开(公告)号：EP2831081B1

公开(公告)日：2016-10-19

申请号：EP13716977.7

申请日：2013-03-26

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Université Montpellier 2, Sciences et Techniques ,  The Regents of the University of California ,  Ecole Nationale Supérieure de Chimie de Montpellier

发明人： CUNIN, Frédérique ,  DURAND, Jean-Olivier ,  SAILOR, Michael J. ,  GARCIA, Marcel ,  SECRET, Emilie ,  GARY-BOBO, Magali ,  MAYNADIER, Marie ,  MORERE, Alain

IPC分类号： C07D487/22 ,  C09K11/59 ,  A61K41/00 ,  A61K31/409 ,  B82Y5/00 ,  A61P35/00

CPC分类号： A61K41/0071 ,  A61K31/28 ,  A61K31/315 ,  A61K31/409 ,  A61K41/008 ,  A61N5/062 ,  C09B47/00 ,  Y10T428/2982