专利检索 ap:("NantBio, Inc." OR "NantOmics, LLC" OR "Nant Holdings IP, LLC") AND inv:"GOLOVATO, Justin" 第 1 页

1.

发明授权
COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS 有权

公开(公告)号：EP3277678B1

公开(公告)日：2020-03-18

申请号：EP16774366.5

申请日：2016-04-01

申请人： NantBio, Inc. , NantOmics, LLC , Nant Holdings IP, LLC

发明人： RABIZADEH, Shahrooz , KAYVAN, Niazi , BUZKO, Oleksandr V. , WEINGARTEN, Paul , MCFARLANE, Heather , JUNCKER-JENSEN, Anna , GOLOVATO, Justin , SOON-SHIONG, Patrick , TAO, Chunlin , HO, David

IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61K31/4725 , A61P35/00

2.

发明公开
COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS 审中-公开
标题翻译：靶向突变K-RAS的组合物和方法

公开(公告)号：EP3277678A1

公开(公告)日：2018-02-07

申请号：EP16774366.5

申请日：2016-04-01

申请人： NantBioScience, Inc. , Nantomics, LLC , Nant Holdings IP, LLC

发明人： RABIZADEH, Shahrooz , KAYVAN, Niazi , BUZKO, Sasha , WEINGARTEN, Paul , MCFARLANE, Heather , JUNCKER-JENSEN, Anna , GOLOVATO, Justin , SOON-SHIONG, Patrick , TAO, Chunlin , HO, David

IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61K31/4725 , A61P35/00

摘要： Compounds and compositions are presented that inhibit K-ras, and especially mutant K-ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.

3.

发明公开
SMALL MOLECULE INHIBITORS OF INFLUENZA A RNA-DEPENDENT RNA POLYMERASE 审中-公开
标题翻译：流感A RNA依赖性RNA聚合酶的小分子抑制剂

公开(公告)号：EP3079693A1

公开(公告)日：2016-10-19

申请号：EP13899201.1

申请日：2013-12-11

申请人： Nant Holdings IP LLC

发明人： NIAZI, Kayvan , RABIZADEH, Shahrooz , LE NY, Anne-Laure , BUZKO, Oleksandr , GOLOVATO, Justin , SOON-SHIONG, Patrick

IPC分类号： A61K31/437 , A61K31/519 , A61P31/16 , A61P31/12

CPC分类号： A61K31/519

摘要： Antiviral compositions and methods are contemplated that are especially effective in the treatment and prevention of influenza A viruses. Also presented are cellular assays to identify small molecule compounds having antiviral properties, particularly as it relates to detection of influenza A RNA-dependent RNA polymerase activity in a mammalian cell independent of other influenza A components. Preferred assays allow for identification of viral replication inhibitors that do not disrupt normal cellular activity.

4.

发明授权
SMALL MOLECULE INHIBITORS OF INFLUENZA A RNA-DEPENDENT RNA POLYMERASE 有权

公开(公告)号：EP3079693B1

公开(公告)日：2019-09-04

申请号：EP13899201.1

申请日：2013-12-11

申请人： Nant Holdings IP, LLC

发明人： NIAZI, Kayvan , RABIZADEH, Shahrooz , LE NY, Anne-Laure , BUZKO, Oleksandr , GOLOVATO, Justin , SOON-SHIONG, Patrick

IPC分类号： A61K31/437 , A61K31/519 , A61P31/16 , A61P31/12

5.

发明授权
CALCIUM FLUX AGONISTS AND METHODS THEREFOR 有权

公开(公告)号：EP2919793B1

公开(公告)日：2020-05-06

申请号：EP13854254.3

申请日：2013-11-13

申请人： Nant Holdings IP, LLC

发明人： NIAZI, Kayvan , RABIZADEH, Shahrooz , GOLOVATO, Justin , SOON-SHIONG, Patrick , LE NY, Anne-Laure , BUZKO, Oleksandr

IPC分类号： A61K31/74 , A61K31/551 , A61K31/496 , A61K31/495 , A61K31/16 , A61K31/66 , A61P17/00 , A61P37/04 , A61P43/00

6.

发明公开
CALCIUM FLUX AGONISTS AND METHODS THEREFOR 审中-公开
标题翻译：钙流激动剂及其方法

公开(公告)号：EP2919793A1

公开(公告)日：2015-09-23

申请号：EP13854254.3

申请日：2013-11-13

申请人： Nant Holdings IP, LLC

发明人： NIAZI, Kayvan , RABIZADEH, Shahrooz , GOLOVATO, Justin , SOON-SHIONG, Patrick , LE NY, Anne-Laure , BUZKO, Oleksandr

IPC分类号： A61K31/74 , A61K31/551 , A61K31/496 , A61K31/495 , A61P17/00

摘要： Calcium flux agonists are used to enhance a TLR- or NOD-mediated stimulus and to so increase an immune response of a host and reduce healing time. Preferred calcium flux agonists include Ca2+ ionophores and SERCA inhibitors and are used in synergistic quantities where a ligand to a TLR or NOD receptor is present.