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公开(公告)号：EP3277678A1
公开(公告)日：2018-02-07
申请号：EP16774366.5
申请日：2016-04-01
发明人： RABIZADEH, Shahrooz , KAYVAN, Niazi , BUZKO, Sasha , WEINGARTEN, Paul , MCFARLANE, Heather , JUNCKER-JENSEN, Anna , GOLOVATO, Justin , SOON-SHIONG, Patrick , TAO, Chunlin , HO, David
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61K31/4725 , A61P35/00
摘要： Compounds and compositions are presented that inhibit K-ras, and especially mutant K-ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.
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公开(公告)号：EP3277678B1
公开(公告)日：2020-03-18
申请号：EP16774366.5
申请日：2016-04-01
发明人： RABIZADEH, Shahrooz , KAYVAN, Niazi , BUZKO, Oleksandr V. , WEINGARTEN, Paul , MCFARLANE, Heather , JUNCKER-JENSEN, Anna , GOLOVATO, Justin , SOON-SHIONG, Patrick , TAO, Chunlin , HO, David
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61K31/4725 , A61P35/00
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3.发明公开
公开(公告)号：EP2914265A1
公开(公告)日：2015-09-09
申请号：EP13851832.9
申请日：2013-11-05
发明人： TAO, Chunlin , HO, David , WANG, Qinwei , POLAT, Tulay , NALLAN, Laxman , SOON-SHIONG, Patrick
IPC分类号： A61K31/506 , A61P35/00
CPC分类号： C07D403/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
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公开(公告)号：EP3261638A1
公开(公告)日：2018-01-03
申请号：EP16756548.0
申请日：2016-02-29
申请人： NantBioScience, Inc.
发明人： TAO, Chunlin , WANG, Qinwei , NALLAN, Laxman , HO, David , POLAT, Tulay , ARP, Forrest , WEINGARTEN, Paul
IPC分类号： A61K31/404 , A61K31/506 , C07D401/12 , C07D403/10
CPC分类号： C07D403/12 , A61K31/506 , A61K31/5377 , A61K45/06 , A61P29/00 , A61P35/00 , A61P37/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14 , C07D487/04
摘要： The present invention provides antitumor agents comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof, methods for making novel compounds and methods for using the compounds. The compounds and compositions in accordance with the invention have utility in treatment of a variety of diseases and have kinase inhibitory activities.
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5.发明公开PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS 审中-公开嘧啶衍生物作为激酶抑制剂及其治疗应用
公开(公告)号：EP3261637A1
公开(公告)日：2018-01-03
申请号：EP15883597.5
申请日：2015-02-27
申请人： NantBioScience, Inc.
发明人： TAO, Chunlin , WANG, Qinwei , NALLAN, Laxman , HO, David , POLAT, Tulay , ARP, Forrest , WEINGARTEN, Paul
IPC分类号： A61K31/404
CPC分类号： C07D403/12 , A61K31/506 , A61K31/5377 , A61K45/06 , A61P29/00 , A61P35/00 , A61P37/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14 , C07D487/04
摘要： The present invention provides antitumor agents comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof, methods for making novel compounds and methods for using the compounds. The compounds and compositions in accordance with the invention have utility in treatment of a variety of diseases and have kinase inhibitory activities.
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公开(公告)号：EP3261638B1
公开(公告)日：2019-05-08
申请号：EP16756548.0
申请日：2016-02-29
申请人： NantBioScience, Inc.
发明人： TAO, Chunlin , WANG, Qinwei , NALLAN, Laxman , HO, David , POLAT, Tulay , ARP, Forrest , WEINGARTEN, Paul
IPC分类号： A61K31/404 , A61K31/506 , C07D401/14 , C07D403/12 , C07D405/14 , C07D403/14 , C07D417/14 , C07D487/14 , A61P29/00 , A61P35/00 , A61P37/00
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