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公开(公告)号：EP3261638A1
公开(公告)日：2018-01-03
申请号：EP16756548.0
申请日：2016-02-29
申请人： NantBioScience, Inc.
发明人： TAO, Chunlin , WANG, Qinwei , NALLAN, Laxman , HO, David , POLAT, Tulay , ARP, Forrest , WEINGARTEN, Paul
IPC分类号： A61K31/404 , A61K31/506 , C07D401/12 , C07D403/10
CPC分类号： C07D403/12 , A61K31/506 , A61K31/5377 , A61K45/06 , A61P29/00 , A61P35/00 , A61P37/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14 , C07D487/04
摘要： The present invention provides antitumor agents comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof, methods for making novel compounds and methods for using the compounds. The compounds and compositions in accordance with the invention have utility in treatment of a variety of diseases and have kinase inhibitory activities.
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公开(公告)号：EP3261638B1
公开(公告)日：2019-05-08
申请号：EP16756548.0
申请日：2016-02-29
申请人： NantBioScience, Inc.
发明人： TAO, Chunlin , WANG, Qinwei , NALLAN, Laxman , HO, David , POLAT, Tulay , ARP, Forrest , WEINGARTEN, Paul
IPC分类号： A61K31/404 , A61K31/506 , C07D401/14 , C07D403/12 , C07D405/14 , C07D403/14 , C07D417/14 , C07D487/14 , A61P29/00 , A61P35/00 , A61P37/00
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3.发明公开PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS 审中-公开嘧啶衍生物作为激酶抑制剂及其治疗应用
公开(公告)号：EP3261637A1
公开(公告)日：2018-01-03
申请号：EP15883597.5
申请日：2015-02-27
申请人： NantBioScience, Inc.
发明人： TAO, Chunlin , WANG, Qinwei , NALLAN, Laxman , HO, David , POLAT, Tulay , ARP, Forrest , WEINGARTEN, Paul
IPC分类号： A61K31/404
CPC分类号： C07D403/12 , A61K31/506 , A61K31/5377 , A61K45/06 , A61P29/00 , A61P35/00 , A61P37/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14 , C07D487/04
摘要： The present invention provides antitumor agents comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof, methods for making novel compounds and methods for using the compounds. The compounds and compositions in accordance with the invention have utility in treatment of a variety of diseases and have kinase inhibitory activities.
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公开(公告)号：EP3277678A1
公开(公告)日：2018-02-07
申请号：EP16774366.5
申请日：2016-04-01
发明人： RABIZADEH, Shahrooz , KAYVAN, Niazi , BUZKO, Sasha , WEINGARTEN, Paul , MCFARLANE, Heather , JUNCKER-JENSEN, Anna , GOLOVATO, Justin , SOON-SHIONG, Patrick , TAO, Chunlin , HO, David
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61K31/4725 , A61P35/00
摘要： Compounds and compositions are presented that inhibit K-ras, and especially mutant K-ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.
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5.发明授权CYCLIC SULFONAMIDE CONTAINING DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAY 有权含有作为抑制剂的信号通路抑制剂衍生物的环状磺酰胺
公开(公告)号：EP2914253B1
公开(公告)日：2018-01-03
申请号：EP13851306.4
申请日：2013-11-04
申请人： NantBioScience, Inc.
CPC分类号： A61K31/425 , C07D275/02 , C07D279/02 , C07D291/06 , C07D417/12 , C07D419/12 , C07D471/04
摘要： The invention relates generally to the creation and use of cyclic sulfonamide containing derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds for the treatment of hyperproliferative diseases and angiogenesis mediated diseases.
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