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1.发明公开
公开(公告)号：EP2990412A1
公开(公告)日：2016-03-02
申请号：EP14788321.9
申请日：2014-04-25
CPC分类号： C07K7/08 , A61L27/12 , A61L27/54 , A61L27/58 , A61L2300/236 , A61L2300/25 , A61L2300/414 , C07K9/00 , C07K14/50
摘要： Provided are a peptide that enables surface treatment of a scaffold for tissue repair that makes it possible to accelerate the repair of living tissue without using a material that negatively affects the repair of living tissue, a complex containing this peptide, a scaffold for tissue repair surface treated using this peptide or this complex, a surface treatment method for a scaffold for tissue repair using this peptide or this complex, and a treatment solution or set of treatment solutions to be used in this surface treatment method. Surface treatment of a scaffold for tissue repair is conducted by combining glycosaminoglycan and a peptide containing adhesive sites and basic sites each comprising predetermined amino acid residues.
摘要翻译： 本发明提供一种肽并允许组织修复支架确实能够加速活组织的修复，而无需使用做了活组织，一个复杂的含有这种肽，组织修复表面的支架的修复不利影响材料的表面处理 使用该肽或该复合物，使用该肽或该复合物，以及治疗的溶液或设定溶液处理的在该表面处理方法中使用的用于组织修复的支架的表面处理方法进行处理。 用于组织修复的支架的表面处理是通过将糖胺聚糖和肽含粘合剂站点和碱性部位各自包含预先确定的氨基酸残基进行的。
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2.发明授权PEPTIDE AND COMPLEX OF SAME, SCAFFOLD FOR TISSUE REPAIR AND SURFACE TREATMENT METHOD FOR SAME, AND SURFACE TREATMENT SOLUTION OR SET OF TREATMENT SOLUTIONS 有权用于组织修复和表面处理方法的肽和复合物，用于组织修复的表面处理溶液或一组处理溶液
公开(公告)号：EP2990412B1
公开(公告)日：2017-11-08
申请号：EP14788321.9
申请日：2014-04-25
CPC分类号： C07K7/08 , A61L27/12 , A61L27/54 , A61L27/58 , A61L2300/236 , A61L2300/25 , A61L2300/414 , C07K9/00 , C07K14/50
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3.发明授权OLIGONUCLEOTIDE, AND THERAPEUTIC AGENT FOR DYSLIPIDEMIA CONTAINING OLIGONUCLEOTIDE AS ACTIVE INGREDIENT 有权含有寡核苷酸作为活性成分的寡脱氧核苷酸的寡核苷酸和治疗剂
公开(公告)号：EP2612914B1
公开(公告)日：2017-06-21
申请号：EP11821885.8
申请日：2011-08-31
申请人： Osaka University , National Cerebral and Cardiovascular Center , Tokyo University Of Science Educational Foundation Administrative Organization
发明人： OBIKA, Satoshi , IMANISHI, Takeshi , YAMAMOTO, Tsuyoshi , NARUKAWA, Keisuke , SHIBA, Mariko , YAMAOKA, Tetsuji , TORIGOE, Hidetaka , YAMASHITA, Atsushi , TACHIBANA Yoichi , KAKINOKI, Sachiro , SASAKI, Kiyomi
IPC分类号： C12N15/09 , A61K31/712 , A61K47/42 , A61P3/10 , A61P43/00
CPC分类号： C12N15/1137 , A61K9/0019 , A61K9/0021 , A61K9/06 , A61K31/712 , C12N2310/11 , C12N2310/3231 , C12N2310/351 , C12Y304/21
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公开(公告)号：EP2191849B1
公开(公告)日：2018-08-01
申请号：EP08833835.5
申请日：2008-09-25
IPC分类号： A61K31/737 , A61K38/00 , A61K39/395 , A61P3/06 , A61P9/04 , A61K47/26 , A61K47/42
CPC分类号： A61K47/4823 , A61K31/737 , A61K38/164 , A61K47/549 , A61K47/61 , A61K2039/505 , C07K16/2833
摘要： To provide a drug for actively metabolizing or excreting a pathogen occurring in vivo. The present invention is directed to a compound which is formed of (A) an adsorbent for a pathogen occurring in the blood or lymph, and (B) a ligand which is specific to an organ or cells capable of metabolizing or excreting the pathogen and which is bonded to the adsorbent via a linker or with no linker, and to a drug containing the same.
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5.发明授权BLOOD-COAGULATION INHIBITING MATERIAL, COATING MATERIAL AND IN VIVO INDWELLING MEMBERS MADE BY USING THE MATERIAL, AND METHOD OF TREATMENT 有权凝血预防材料涂层材料和所制造体内VERWEILELEMENTE材料和治疗方法
公开(公告)号：EP2098256B1
公开(公告)日：2016-06-08
申请号：EP07832058.7
申请日：2007-11-16
IPC分类号： A61L33/00 , A61F2/06 , A61M25/00 , C08L53/00 , C09D153/00
CPC分类号： A61L33/068 , C08L53/00 , C09D153/00 , C08L2666/14 , C08L2666/02
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6.发明公开OLIGONUCLEOTIDE, AND THERAPEUTIC AGENT FOR DYSLIPIDEMIA CONTAINING OLIGONUCLEOTIDE AS ACTIVE INGREDIENT 有权OIGONUKLEOTID UND THERAPEUTISCHES MITTEL GEGENDYSLIPIDÄMIEMIT DEM OLIGONUKLEOTID ALS WIRKSTOFF
公开(公告)号：EP2612914A1
公开(公告)日：2013-07-10
申请号：EP11821885.8
申请日：2011-08-31
申请人： Osaka University , National Cerebral and Cardiovascular Center , Tokyo University Of Science Educational Foundation Administrative Organization
发明人： OBIKA, Satoshi , IMANISHI, Takeshi , YAMAMOTO, Tsuyoshi , NARUKAWA, Keisuke , SHIBA, Mariko , YAMAOKA, Tetsuji , TORIGOE, Hidetaka , YAMASHITA, Atsushi , TACHIBANA Yoichi , KAKINOKI, Sachiro , SASAKI, Kiyomi
IPC分类号： C12N15/09 , A61K31/712 , A61K47/42 , A61P3/10 , A61P43/00
CPC分类号： C12N15/1137 , A61K9/0019 , A61K9/0021 , A61K9/06 , A61K31/712 , C12N2310/11 , C12N2310/3231 , C12N2310/351 , C12Y304/21
摘要： An object of the present invention is to provide an oligonucleotide useful as a therapeutic agent for dyslipidemia that has excellent binding affinity to the PCSK9 gene as well as stability and safety. The oligonucleotide of the present invention contains a sugar-modified nucleoside, the sugar-modified nucleoside has a bridging structure between 4'-position and 2'-position, and the oligonucleotide can bind to the human PCSK9 gene. Also, the present invention provides a therapeutic agent for dyslipidemia containing the oligonucleotide as an active ingredient, and the therapeutic agent preferably contains a bioabsorbable material as a carrier. The bioabsorbable material is preferably atelocollagen or peptide gel.
摘要翻译： 本发明的目的是提供可用作对于与PCSK9基因具有优异的结合亲和力以及稳定性和安全性的用于血脂异常的治疗剂的寡核苷酸。 本发明的寡核苷酸含有糖修饰的核苷，糖修饰的核苷具有4'-位和2'-位之间的桥连结构，寡核苷酸可以结合人PCSK9基因。 此外，本发明提供了含有寡核苷酸作为活性成分的血脂异常的治疗剂，优选以生物体吸收性材料为载体。 生物可吸收材料优选为胶原蛋白或肽凝胶。
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7.发明公开ARTIFICIAL BLOOD VESSEL, AND METHOD FOR PRODUCING ARTIFICIAL BLOOD VESSEL 审中-公开维多利亚州ZER HERSTELLUNG EINESKÜNSTLICHENBLUTGEFÄSSES
公开(公告)号：EP2913067A1
公开(公告)日：2015-09-02
申请号：EP13849269.9
申请日：2013-09-05
申请人： JMS Co., Ltd.
发明人： YAMAOKA, Tetsuji , MAHARA, Atsushi
CPC分类号： A61F2/062 , A61F2/82 , A61F2210/0076 , A61F2240/001 , A61K35/12 , A61K35/44 , A61L27/36 , A61L27/3683 , A61L27/507 , C07K14/78
摘要： In order to provide an artificial blood vessel that can prevent formation of a thrombus and a method for producing the artificial blood vessel, an artificial blood vessel is used (i) in which a peptide including a specific amino acid sequence has been added to an extracellular matrix obtained from a bio-derived vascular tissue and (ii) whose lumen has a cross sectional diameter of 4 mm or less.
摘要翻译： 为了提供能够防止血栓形成的人造血管和制造人造血管的方法，使用人造血管（i），其中将包含特定氨基酸序列的肽加入细胞外 从生物衍生的血管组织获得的基质和（ii）其内腔具有4mm或更小的横截面直径。
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