公开(公告)号：EP2505590A1

公开(公告)日：2012-10-03

申请号：EP10833327.9

申请日：2010-11-26

申请人： Daiso Co., Ltd. ,  Osaka City University ,  Osaka Prefecture University Public Corporation ,  Kyoto Prefectural Public University Corporation ,  National University Corporation Nara Institute of Science and Technology

发明人： SUZUKI, Toshio ,  UEDA, Hideaki ,  NAGASAKI, Takeshi ,  KIRIHATA, Mitsunori ,  NUMATA, Munenori ,  IKEDA, Atsushi

IPC分类号： C07F5/02 ,  A61K47/36 ,  C08B37/00 ,  C01B31/02 ,  C01B35/00 ,  C12P19/04

CPC分类号： C01B31/0273 ,  B22F1/0062 ,  B22F1/0074 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/174 ,  C07F5/027 ,  C08B37/0057 ,  C08K3/02 ,  C08K3/041 ,  C08K3/045 ,  C08K3/06 ,  C08K3/08 ,  Y10S977/734 ,  Y10S977/742 ,  C08L5/00

摘要： Provided is a complex comprising a hydrophobic cluster compound and a β-1, 3-1, 6-D-glucan having a degree of branching (a ratio of β-1,6 linkages to β-1,3 linkages) of 50 to 100%.

摘要翻译： 本发明提供了一种复合物，其包含疏水性簇化合物和具有支化度（ⅱ-1,6键与2-1,3-键的比例）为50的ι-1,3-1,6-D-葡聚糖 100％。

公开(公告)号：EP2123288B1

公开(公告)日：2011-05-04

申请号：EP08704499.6

申请日：2008-02-06

申请人： National University Corporation Nara Institute of Science and Technology

发明人： IKEDA, Atsushi ,  KIKUCHI, Jun-ichi

IPC分类号： A61K31/724 ,  A61K9/127 ,  A61K47/40 ,  A61P35/00

CPC分类号： A61K31/724 ,  A61K8/14 ,  A61K8/31 ,  A61K8/738 ,  A61K9/127 ,  A61K9/1272 ,  A61K9/1277 ,  A61K41/0057 ,  A61K47/40 ,  A61K47/6951 ,  A61K2800/522 ,  A61K2800/81 ,  A61Q19/00 ,  B82Y5/00 ,  A61K2300/00

摘要： A solution containing a cyclodextrin-C70 complex is mixed with a solution containing a liposome-forming lipid at 10-45˚C, thereby producing a C70-containing liposome having the intrinsic physical properties of C70 fullerene, which liposome is stably soluble in a polar solvent. Specifically disclosed are a C70-containing liposome which has the intrinsic physical properties of C70 fullerene and is stably soluble in a polar solvent, a method for producing such a C70-containing liposome, and a use of such a C70-containing liposome.

公开(公告)号：EP2123288A1

公开(公告)日：2009-11-25

申请号：EP08704499.6

申请日：2008-02-06

申请人： National University Corporation Nara Institute of Science and Technology

发明人： IKEDA, Atsushi ,  KIKUCHI, Jun-ichi

IPC分类号： A61K33/44 ,  A61K9/127 ,  A61K47/24 ,  A61K47/40 ,  A61P35/00

CPC分类号： A61K31/724 ,  A61K8/14 ,  A61K8/31 ,  A61K8/738 ,  A61K9/127 ,  A61K9/1272 ,  A61K9/1277 ,  A61K41/0057 ,  A61K47/40 ,  A61K47/6951 ,  A61K2800/522 ,  A61K2800/81 ,  A61Q19/00 ,  B82Y5/00 ,  A61K2300/00

摘要： A solution containing a C 70 cyclodextrin complex and a solution containing a lipid that is capable of forming a liposome are mixed together at a temperature in a range of 10 °C to 45 °C. This produces a C 70 -incorporated liposome which keeps a physical property that the C 70 fullerene originally has, and is stably solubilized in a polar solvent. Hence, the present invention provides a C 70 -incorporated liposome which keeps a physical property that the C 70 fullerene originally has, and which is stably solubilized in a polar solvent, a production method of the same, and a use of the same.

摘要翻译： 含有C 70环糊精复合物的溶液和含能够形成脂质体的脂质的溶液在10℃〜45℃的温度范围内混合。 这产生了C 70-掺入的脂质体，其保持C 70富勒烯最初具有的物理性质，并且稳定地溶解在极性溶剂中。 因此，本发明提供一种C 70-掺入的脂质体，其保持C 70富勒烯最初具有的物理性质，并且其稳定地溶解在极性溶剂中，其制备方法及其用途。