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公开(公告)号：EP2097108A2
公开(公告)日：2009-09-09
申请号：EP07868101.2
申请日：2007-12-27
CPC分类号： C08G65/33337 , A61K47/60 , C08G65/3332 , C08G65/33396 , C08G65/3348 , C08L2203/02
摘要： The present invention provides Factor IX moiety-polymer conjugates having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
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公开(公告)号：EP1765411A2
公开(公告)日：2007-03-28
申请号：EP05767845.0
申请日：2005-06-30
CPC分类号： A61K47/48215 , A61K38/4846 , A61K47/60 , C12N9/644 , C12N9/96 , C12Y304/21022
摘要： Conjugates of a Factor IX moiety and one or more water-solute e polymers are provided. Typically, the water-soluble polymer is polyethylene glycol) or a derivative thereof. Also provided (among other things) are compositions comprising the conjugates, methods of making the conjugates, and methods of administering to a patient compositions comprising the conjugates.
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公开(公告)号：EP1596887A2
公开(公告)日：2005-11-23
申请号：EP04715165.9
申请日：2004-02-26
IPC分类号： A61K47/48
摘要： Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.
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4.发明公开VON WILLEBRAND FACTOR- AND FACTOR VIII-POLYMER CONJUGATES HAVING A RELEASABLE LINKAGE 有权血管性血友病因子和因子VIII WITH聚合物缀合物可分离的连接
公开(公告)号：EP2114458A2
公开(公告)日：2009-11-11
申请号：EP07868153.3
申请日：2007-12-27
发明人： BOSSARD, Mary, J. , STEPHENSON, Gayle , FANG, Zhihao , ZAPPE, Harold , MITCHELL, Stacy , ZHANG, Ping , SCHEIFLINGER, Friedrich , TURECEK, Peter , SIEKMANN, Juergen , VARADI, Katalin , GRITSCH, Herbert
CPC分类号： C07K14/755 , A61K47/60
摘要： The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
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公开(公告)号：EP2099495A2
公开(公告)日：2009-09-16
申请号：EP06800776.4
申请日：2006-08-04
发明人： BOSSARD, Mary, J. , ZHANG, Ping
IPC分类号： A61K47/48 , C07K14/535
CPC分类号： C07K14/535 , A61K47/60 , C07K14/53
摘要： Conjugates of a G-CSF moiety and one or more nonpeptidic water-soluble polymers are provided. Typically, the nonpeptidic water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions comprising conjugates to a patient.
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公开(公告)号：EP1885403A2
公开(公告)日：2008-02-13
申请号：EP06749809.7
申请日：2006-04-11
发明人： BOSSARD, Mary, J. , MITCHELL, Stacy
CPC分类号： A61K47/48215 , A61K38/00 , A61K47/60 , C12N9/52
摘要： Provided herein are water-soluble polymer conjugates and polymer-based compositions of antimicrobial agents. Also provided are methods for synthesizing and administering such conjugates and compositions.
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公开(公告)号：EP1968644A2
公开(公告)日：2008-09-17
申请号：EP06847728.0
申请日：2006-12-18
IPC分类号： A61K47/48 , C07C323/12 , C07D213/70 , C07K14/605 , A61P3/10
CPC分类号： C07K17/08 , A61K47/60 , C07K14/605
摘要： Conjugates of a GLP-I moiety may be covalently attached to one or more water-soluble polymers. For instance, a GLP-I polymer conjugate may include a GLP-I moiety releasably attached at its N-terminus to a water-soluble polymer. The GLP-I polymer conjugate may include a GLP-I moiety covalently attached to a water-soluble polymer, wherein the GLP-I moiety possesses an N-methyl substituent. The GLP-I polymer conjugate may include a GLP-I moiety covalently attached at a polymer attachment site to a water-soluble polymer, wherein the GLP-I moiety is glycosylated at a site separate from the polymer attachment site.
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公开(公告)号：EP1848461A2
公开(公告)日：2007-10-31
申请号：EP06720886.8
申请日：2006-02-16
IPC分类号： A61K47/48
CPC分类号： C08G65/333 , A61K38/00 , A61K47/60 , C07K14/505 , C08G65/329
摘要： Conjugates of an EPO moiety and one or more non-peptidic water soluble polymers are provided. Typically, the non-peptidic water soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising such conjugates, methods of making conjugates, and methods of administering compositions comprising such conjugates to a patient.
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公开(公告)号：EP1768700A2
公开(公告)日：2007-04-04
申请号：EP05771041.0
申请日：2005-07-14
发明人： BOSSARD, Mary, J. , ZHANG, Ping
CPC分类号： C07K14/535 , A61K38/00 , A61K47/60
摘要： Conjugates of a GM-CSF moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions comprising conjugates to a patient.
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10.发明公开COMPOSITIONS COMPRISING TWO DIFFERENT POPULATIONS OF POLYMER-ACTIVE AGENT CONJUGATES 审中-公开随着高分子-ACTIVE结合物的两个不同的组组合物
公开(公告)号：EP1691841A2
公开(公告)日：2006-08-23
申请号：EP04813631.1
申请日：2004-12-10
发明人： BOSSARD, Mary, J.
IPC分类号： A61K47/48
摘要： Compositions comprising two different populations of polymer-active agent conjugates, wherein the weight average molecular weight of the polymers associated with each population is different, are provided. Also provided are methods preparing such compositions and methods for administering such compositions.
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