公开(公告)号：EP3928797B1

公开(公告)日：2024-10-09

申请号：EP20760024.8

申请日：2020-02-17

IPC: A61K47/60 ,  A61K31/4745 ,  A61K47/64 ,  A61P35/00 ,  C08G65/333 ,  A61K47/55

CPC classification number: A61K47/64 ,  A61P35/00 ,  A61K47/60 ,  A61K47/55 ,  C08G65/33396

公开(公告)号：EP3347402B1

公开(公告)日：2019-08-07

申请号：EP16766066.1

申请日：2016-09-09

Applicant: IP2IPO Innovations Limited

Inventor： GAFFNEY, Piers ,  LIVINGSTON, Andrew ,  CHEN, Rongjun ,  DONG, Ruijiao ,  LIU, Ruiyi ,  MARCHETTI, Patrizia

IPC: C08G65/32 ,  C08G65/325 ,  C08G65/333

CPC classification number: C08G65/33396 ,  A61K47/60 ,  A61K49/0054 ,  A61K49/128 ,  C08G65/32 ,  C08G65/325 ,  C08G65/333 ,  C08G65/33317 ,  C08G65/3342 ,  C08G65/3344 ,  C08G65/3348

Abstract: Processes of preparing defined monomer sequence polymers are disclosed, in which a backbone portion of the polymer is first prepared by performing one or more sequential monomeric coupling reactions with intervening membrane diafiltration purification/isolation steps, followed by a step of decorating the backbone portion with one or more side chains at predetermined positions along its length. The process represents an improvement on prior art techniques, which impose limitations on the size of the side chains that may be present. Defined monomer sequence polymers that are obtainable by the processes are also disclosed.

公开(公告)号：EP3227348A4

公开(公告)日：2018-07-18

申请号：EP15865826

申请日：2015-12-03

Applicant: UNIV COLUMBIA

Inventor： KOBERTSTEIN JEFFREY T ,  SAMANTA SANJOY ,  DE SILVA CHATHURANGA

IPC: C08F16/02 ,  A61K47/59

CPC classification number: A61K47/60 ,  A01N25/04 ,  A01N25/10 ,  A61K9/06 ,  A61K9/1075 ,  A61K31/7068 ,  A61K47/59 ,  A61K47/6907 ,  A61P35/00 ,  A61P35/02 ,  C08F220/18 ,  C08G65/33396 ,  C08G65/48 ,  C08G81/00 ,  C08G2230/00 ,  C08G2650/04 ,  C08G2650/30 ,  C08G2650/44 ,  C08J3/075 ,  C08J3/24 ,  C08J2371/08 ,  C08L33/06

Abstract: The invention provides for novel thermo-responsive polymers and compositions comprising the same. In some embodiments, the polymers are water soluble, pH-degradable and have tunable lower critical solution temperatures. Other aspects of the invention include micelles and gels comprising the thermo-responsive polymers and derivatives thereof, as well as methods of delivering therapeutic agents comprising administering a biodegradable gel or micelle comprising a polyacetal compound cross-linked with a linker.

公开(公告)号：EP3318282A1

公开(公告)日：2018-05-09

申请号：EP16818087.5

申请日：2016-07-01

Applicant: The University Of Tokyo

Inventor： KATAOKA, Kazunori ,  ANRAKU, Yasutaka ,  HORI, Mao

IPC: A61K47/34 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26

CPC classification number: A61K9/1075 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61K47/34 ,  C08G65/08 ,  C08G65/33396 ,  C08G69/36 ,  C08G69/48 ,  C08G81/00

Abstract: The present invention provides a carrier containing a first block copolymer and a second block copolymer, wherein the first block copolymer is a block copolymer of a first non-charged segment and a first complex-forming segment, at least some proportion of said first block copolymer is modified by a first molecule, the second block copolymer is a block copolymer of a second non-charged segment and a second complex-forming segment, and wherein at least some proportion of said second block copolymer is modified by a second molecule, said first molecule is a GLUT1 ligand, and said second molecule is different from the first molecule.

Abstract translation: 本发明提供含有第一嵌段共聚物和第二嵌段共聚物的载体，其中第一嵌段共聚物是第一不带电荷的链段和第一配合物形成链段的嵌段共聚物，至少一部分所述第一嵌段共聚物 由第一分子改性，所述第二嵌段共聚物为第二不带电链段和第二配合物形成链段的嵌段共聚物，并且其中所述第二嵌段共聚物的至少一部分由第二分子改性，所述第一 分子是GLUT1配体，并且所述第二分子不同于第一分子。

公开(公告)号：EP3151796A4

公开(公告)日：2018-01-10

申请号：EP15802421

申请日：2015-06-04

Applicant: ZIM BIOSCIENCES INC

Inventor： MEYER JANE M ,  MALAVIA NIKITA ,  CHARLES STEPHEN ALEXANDER

IPC: A61K8/65 ,  A61K8/86 ,  A61K38/17 ,  A61Q7/00 ,  A61Q19/00

CPC classification number: A61K8/86 ,  A61K8/65 ,  A61K9/0014 ,  A61K9/08 ,  A61K31/77 ,  A61K38/1748 ,  A61K47/34 ,  A61L15/32 ,  A61L15/44 ,  A61L26/0047 ,  A61L26/0066 ,  A61L2300/252 ,  A61L2300/412 ,  A61Q7/00 ,  A61Q19/00 ,  A61Q19/007 ,  C08G65/33396

Abstract: Provided herein are methods for improving skin quality in a subject comprising administering to the skin a pharmaceutical composition comprising a polypeptide covalently bound to a hydrophilic polymer and/or a polysaccharide covalently bound to a hydrophilic polymer.

公开(公告)号：EP3244929A1

公开(公告)日：2017-11-22

申请号：EP16706691.9

申请日：2016-01-15

Applicant: Massachusetts Institute of Technology

Inventor： GRIFFITH, Linda, G. ,  IMPERIALI, Barbara ,  COOK, Christi, D. ,  AHRENS, Caroline, Chopko ,  RENGGLI, Kasper ,  VALDEZ MACIAS, Jorge, L.

IPC: A61K47/50 ,  A61K38/00 ,  A61K9/06 ,  A61K47/10 ,  C12Q1/37

CPC classification number: C12N5/0068 ,  A61K9/06 ,  A61K38/1808 ,  A61K38/1883 ,  A61K47/10 ,  A61K47/6903 ,  C08G65/33396 ,  C08G65/3342 ,  C08G2210/00 ,  C08G2650/04 ,  C08G2650/20 ,  C08J3/075 ,  C08J3/24 ,  C08J2371/02 ,  C12N5/0012 ,  C12N5/0062 ,  C12N2513/00 ,  C12N2533/30 ,  C12N2537/10 ,  G01N33/5005 ,  G01N33/574

Abstract: Methods of forming, dissolving, and functionalizing an extracellular matrix gel on demand based on cross-linking, modification, and dissolution of hydrogels using transpeptidase (e.g. sortase) are disclosed. Also provided are hydrogels comprising one or more macromers crosslinked to a mixture of peptides, wherein all or a portion of the peptides in the mixture comprise a recognition motif cleavable by a transpeptidase (e.g., sortase).

公开(公告)号：EP3174524A1

公开(公告)日：2017-06-07

申请号：EP15750831.8

申请日：2015-07-24

Applicant: SupraPolix B.V.

Inventor： PEETERS, Joris Wilhelmus ,  MES, Tristan ,  JANSSEN, Henricus Marie ,  BOSMAN, Anton Willem

IPC: A61K9/00 ,  A61L24/00 ,  A61L26/00 ,  C08G65/329 ,  C08G65/333 ,  A61K47/10 ,  A61K47/50

CPC classification number: C08G18/506 ,  A61K8/87 ,  A61K9/0019 ,  A61K9/0024 ,  A61K47/10 ,  A61K47/34 ,  A61K2800/10 ,  A61L24/0031 ,  A61L26/008 ,  A61L27/52 ,  A61Q19/00 ,  C08G18/755 ,  C08G18/758 ,  C08G65/329 ,  C08G65/333 ,  C08G65/33303 ,  C08G65/33348 ,  C08G65/33396 ,  C08G2210/00 ,  C08G2650/04 ,  C08G2650/50 ,  C08L2203/02

Abstract: This disclosure relates to new injectable hydrogel materials that consist of water gellants comprising linear hydrophilic polymers that comprise hydrogen bonding units in the backbone combined with cross-linkable end groups, resulting in dynamic yet firm hydrogel materials that are easily processable, are highly elastic, show adhesive properties and are self-healing and are especially suitable for biomedical applications.

Abstract translation: 本发明涉及新型可注射水凝胶材料，其由包含线性亲水性聚合物的水胶凝剂材料组成，所述线性亲水性聚合物包含骨架中的氢键单元以及可交联端基，如果易于加工的动态而坚固的水凝胶材料具有高度弹性， 粘合性能和自愈性，特别适用于生物医学应用。

公开(公告)号：EP2717916B1

公开(公告)日：2017-03-08

申请号：EP12728014.7

申请日：2012-06-11

Applicant: Mersana Therapeutics, Inc.

Inventor： YURKOVETSKIY, Aleksandr ,  YIN, Mao ,  LOWINGER, Timothy, B. ,  THOMAS, Joshua, D. ,  HAMMOND, Charles, E. ,  STEVENSON, Cheri, A. ,  BODYAK, Natalya, D. ,  CONLON, Patrick, R. ,  GUMEROV, Dmitry, R.

IPC: A61K47/59 ,  C07K5/02 ,  C07K7/06 ,  A61P35/00

CPC classification number: A61K47/6849 ,  A61K31/4745 ,  A61K47/59 ,  A61K47/64 ,  A61K47/6803 ,  A61K47/6883 ,  C07K7/02 ,  C07K16/32 ,  C08G65/33396 ,  C08G65/334

Abstract: A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier comprising poly(1-hydroxymethylethylene hydroxymethyl-formal) (PHF) substituted with one or more -L D -D, the protein based recognition-molecule being connected to the polymeric carrier by L p . Each occurrence of D is independently a therapeutic agent having a molecular weight ‰¤ 5 kDa, L D and L p are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds comprising PHF useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates of their compositions.

Abstract translation: 本文提供药物缀合物。 缀合物包含基于蛋白质的识别分子（PBRM）和被一个或多个-LD-D取代的聚合物载体，基于蛋白质的识别分子通过LP连接到聚合物载体上。 每次发生的D独立地是具有分子量＆nlE; 5kDa的治疗剂。 LD和LP分别是将治疗剂和PBRM分别连接到聚合物载体的接头。 还公开了可用于与PBRM缀合以形成本文所述的聚合物 - 药物-PBRM缀合物的聚合物支架，包含缀合物的组合物，其制备方法，以及用缀合物或其组合物治疗各种病症的方法。

公开(公告)号：EP2652040A4

公开(公告)日：2016-11-16

申请号：EP11849750

申请日：2011-11-28

Applicant: HEXION RES BELGIUM SA

Inventor： ELMORE JIM D ,  CORLEY LARRY STEVEN ,  HITE JERRY R

IPC: C08L63/00 ,  C08G59/44

CPC classification number: C08G65/33306 ,  C08G59/44 ,  C08G65/2621 ,  C08G65/2624 ,  C08G65/2627 ,  C08G65/33396 ,  C08G73/028 ,  C08L63/00 ,  C08L79/02

Abstract: Compositions and methods for forming surfactants, aqueous dispersions, and curing agents are provided. In one aspect, the invention relates to improved epoxy functional surfactants prepared by reaction of an epoxy composition and an amidoamine composition formed from a blend of acid-terminated polyoxyalkylene polyols. The improved epoxy functional surfactants may be reacted with an excess of epoxy composition and water to result in an aqueous dispersion. The amidoamone composition may be a reaction mixture of a diamine compound and an acid terminated polyoxyalkylene composition formed from two or more polyoxyalkylene polyol compounds. The epoxy functional surfactant may be reacted with amine compounds to form a compound suitable as a curing agent.

公开(公告)号：EP3078699A1

公开(公告)日：2016-10-12

申请号：EP14866860.1

申请日：2014-12-02

Applicant: Jenkem Technology Co. Ltd. (Tianjin)

Inventor： CHEN, Xiaomeng ,  LIN, Meina ,  ZHAO, Xuan

IPC: C08G81/00 ,  C08G83/00

CPC classification number: A61K47/60 ,  C08G65/325 ,  C08G65/332 ,  C08G65/333 ,  C08G65/33327 ,  C08G65/33331 ,  C08G65/33337 ,  C08G65/33396 ,  C08G65/3346 ,  C08G65/337 ,  C08G2650/30

Abstract: Provided is a multi-arm polyethylene glycol-azido derivative of general formula I, wherein R is a central molecule, which is selected from a polyhydroxy structure, a polyamino structure or a polycarboxyl structure; n is the number of branches or arms, n≧3; PEG is the same or different -(CH 2 CH 2 O) m -, the average value of m being an integer from 3 to 250; X is a linking group of an azido end group; k is the number of the branches having the azido end group; F is selected from the group consisting of amino, carboxyl, sulfhydryl, ester group, maleic imide group and acrylic group; and Y is a linking group of an end group F.

Abstract translation: 提供通式I的多臂聚乙二醇 - 叠氮基衍生物，其中R是选自多羟基结构，聚氨基结构或多羧基结构的中心分子; n是分支或武器的数量，n‰§3; PEG相同或不同 - （CH 2 CH 2 O）m - ，m的平均值为3至250的整数; X是叠氮基端基的连接基团; k是具有叠氮基端基的支链数; F选自氨基，羧基，巯基，酯基，马来酰亚胺基和丙烯酸基; Y是末端基团F的连接基团。