公开(公告)号：EP3226819A1

公开(公告)日：2017-10-11

申请号：EP15823030.0

申请日：2015-11-25

申请人： New Phase Ltd.

发明人： HOF, Raphael ,  KHANDADASH, Raz ,  FREMDER, Ella

IPC分类号： A61F7/00 ,  A61N1/40 ,  A61K41/00

CPC分类号： A61K41/0052 ,  A61F7/00 ,  A61K47/06 ,  A61K47/549 ,  A61K47/60 ,  A61K47/6929 ,  A61K47/6935 ,  A61N1/406

摘要： Apparatus and methods are described for use with a subject suffering from cancer. A nanoparticle (22) includes an inner core (30) that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change. An outer layer (32) disposed around the inner core includes a plurality of nano-spheres (34) of at least one metal, and a plurality of molecules (38) of a substance that binds preferentially with cancerous cells relative to non-cancerous cells. The nanoparticle has a volume of at least 65,000 nm3 and is elongatable into an ellipsoid, such that, when the nanoparticle is maximally elongated, each of the semi-axes defined by the ellipsoid is greater than 5 nm, and at least two of the semi axes of the ellipsoid are less than 30 nm. Other applications are also described.

摘要翻译： 描述了用于患有癌症的受试者的装置和方法。 纳米颗粒（22）包括内芯（30），所述内芯包含被配置为通过经历相变来吸收熔化潜热的相变材料。 围绕内核布置的外层（32）包括多个至少一种金属的纳米球（34）和多个分子（38），所述分子（38）相对于非癌细胞优先与癌细胞结合 。 纳米颗粒具有至少65,000nm 3的体积并且可伸长成椭圆体，使得当纳米颗粒被最大程度地拉长时，椭圆体所限定的每个半轴大于5nm，并且至少两个 椭圆体的半轴小于30nm。 其他应用也被描述。

公开(公告)号：EP3585432A1

公开(公告)日：2020-01-01

申请号：EP18714616.2

申请日：2018-02-20

申请人： New Phase Ltd.

发明人： HOF, Raphael

IPC分类号： A61K41/00 ,  A61K47/69 ,  A61P35/00

公开(公告)号：EP3226819B1

公开(公告)日：2018-10-24

申请号：EP15823030.0

申请日：2015-11-25

申请人： New Phase Ltd.

发明人： HOF, Raphael ,  KHANDADASH, Raz ,  FREMDER, Ella

IPC分类号： A61F7/00 ,  A61N1/40 ,  A61K41/00 ,  A61K47/54 ,  A61K47/69

CPC分类号： A61K41/0052 ,  A61F7/00 ,  A61K47/06 ,  A61K47/549 ,  A61K47/60 ,  A61K47/6929 ,  A61K47/6935 ,  A61N1/406

摘要： Apparatus and methods are described for use with a subject suffering from cancer. A nanoparticle (22) includes an inner core (30) that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change. An outer layer (32) disposed around the inner core includes a plurality of nano-spheres (34) of at least one metal, and a plurality of molecules (38) of a substance that binds preferentially with cancerous cells relative to non-cancerous cells. The nanoparticle has a volume of at least 65,000 nm3 and is elongatable into an ellipsoid, such that, when the nanoparticle is maximally elongated, each of the semi-axes defined by the ellipsoid is greater than 5 nm, and at least two of the semi axes of the ellipsoid are less than 30 nm. Other applications are also described.