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    PHASE-CHANGE NANOPARTICLE
    1.
    发明授权
    PHASE-CHANGE NANOPARTICLE 有权

    公开(公告)号：EP3226819B1

    公开(公告)日：2018-10-24

    申请号：EP15823030.0

    申请日：2015-11-25

    申请人： New Phase Ltd.

    发明人： HOF, Raphael ,  KHANDADASH, Raz ,  FREMDER, Ella

    IPC分类号： A61F7/00 ,  A61N1/40 ,  A61K41/00 ,  A61K47/54 ,  A61K47/69

    CPC分类号： A61K41/0052 ,  A61F7/00 ,  A61K47/06 ,  A61K47/549 ,  A61K47/60 ,  A61K47/6929 ,  A61K47/6935 ,  A61N1/406

    摘要： Apparatus and methods are described for use with a subject suffering from cancer. A nanoparticle (22) includes an inner core (30) that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change. An outer layer (32) disposed around the inner core includes a plurality of nano-spheres (34) of at least one metal, and a plurality of molecules (38) of a substance that binds preferentially with cancerous cells relative to non-cancerous cells. The nanoparticle has a volume of at least 65,000 nm3 and is elongatable into an ellipsoid, such that, when the nanoparticle is maximally elongated, each of the semi-axes defined by the ellipsoid is greater than 5 nm, and at least two of the semi axes of the ellipsoid are less than 30 nm. Other applications are also described.

    SYSTEMS AND METHODS FOR PROVIDING ALTERNATING MAGNETIC FIELD THERAPY
    3.
    发明公开
    SYSTEMS AND METHODS FOR PROVIDING ALTERNATING MAGNETIC FIELD THERAPY 审中-公开
    用于提供交替磁场治疗的系统和方法

    公开(公告)号：EP3265005A1

    公开(公告)日：2018-01-10

    申请号：EP16759407.6

    申请日：2016-03-02

    申请人： Kaio Therapy, LLC

    发明人： PETTY, Christopher ,  ZILBERTER, Lev ,  POPOW, John

    IPC分类号： A61B18/04

    CPC分类号： A61N2/02 ,  A61N1/406 ,  A61N2/004

    摘要： Examples of systems and methods for providing alternating magnetic field therapy are provided. One example method includes the steps of positioning a target proximate to a first end of an alternating magnetic field (AMF) head, the AMF head comprising an electrical coil and a ferromagnetic core, the electrical coil having a substantially circular cross-section that is substantially centered on a first axis, the AMF head having the first end corresponding to a first end of the coil and a second end corresponding to a second end of the coil; generating and transmitting an alternating current (AC) signal to the AMF head; determining a temperature of the target based on a sensor signal from a temperature sensor; in response to determining the temperature, modifying the AC signal based on a difference between the temperature and a predetermined target temperature.

    RADIOFREQUENCY HYPERTHERMIA DEVICE WITH DOUBLE IMPEDANCE MATCHING SYSTEM
    4.
    发明公开
    RADIOFREQUENCY HYPERTHERMIA DEVICE WITH DOUBLE IMPEDANCE MATCHING SYSTEM 审中-公开
    具有双阻抗匹配系统的射频超热疗装置

    公开(公告)号：EP3231478A1

    公开(公告)日：2017-10-18

    申请号：EP16165109.6

    申请日：2016-04-13

    申请人： Oncotherm Kft.

    发明人： SZÁSZ, Olivér ,  ILURI, Nora ,  SZÁSZ, Andras

    IPC分类号： A61N1/40 ,  A61N5/10 ,  A61K41/00 ,  B82Y5/00

    CPC分类号： A61N1/403 ,  A61N1/406

    摘要： The present invention relates to a radiofrequency (RF) hyperthermia device comprising a radiofrequency carrier signal generator (1), a radiofrequency amplifier (4), an electrode (6) and a counter-electrode (7), a first impedance measuring means (2), a first impedance matching means (3), a second impedance measuring means (5), and at least one second impedance matching means (8 or 8'), wherein the at least one second impedance matching means is configured and adapted to match the second impedance measured by the second impedance measuring means to the predetermined value. This radiofrequency (RF) hyperthermia device is designed for the hyperthermia treatment by optimized double impedance matching system.

    摘要翻译： 本发明涉及包括射频载波信号发生器（1），射频放大器（4），电极（6）和反电极（7）的射频（RF）热疗装置，第一阻抗测量装置 ），第一阻抗匹配装置（3），第二阻抗测量装置（5）以及至少一个第二阻抗匹配装置（8或8'），其中所述至少一个第二阻抗匹配装置被配置并适于匹配 由第二阻抗测量装置测量的第二阻抗与预定值进行比较。 这种射频（RF）热疗装置是通过优化的双阻抗匹配系统为高热治疗设计的。

    IRON OXIDE NANOPARTICLES AND THEIR SYNTHESIS BY CONTROLLED OXIDATION
    5.
    发明公开
    IRON OXIDE NANOPARTICLES AND THEIR SYNTHESIS BY CONTROLLED OXIDATION 审中-公开
    氧化铁纳米颗粒及其控制氧化合成

    公开(公告)号：EP3215131A1

    公开(公告)日：2017-09-13

    申请号：EP15856388.2

    申请日：2015-10-30

    申请人： University of Washington

    发明人： KRISHNAN, Kannan M. ,  KHANDHAR, Amit Praful ,  FERGUSON, Richard M. ,  KEMP, Scott Jeffrey

    IPC分类号： A61K9/16

    CPC分类号： A61K9/5115 ,  A61K9/0009 ,  A61K41/0052 ,  A61K49/1857 ,  A61K49/186 ,  A61N1/406

    摘要： Disclosed herein are iron oxide nanoparticles having an iron (II) content in a metastable state that is intermediate the iron (II) content of wüstite and magnetite. The disclosed iron oxide nanoparticles exhibit unexpectedly beneficial magnetic properties (e.g., saturation magnetization) resulting from both the size of the nanoparticles and the iron (II) content. Accordingly, the iron oxide nanoparticles are attractive for magnetic imaging applications, such as magnetic particle imaging. Methods of forming the iron oxide nanoparticles are also provided, such methods including a controlled oxidation step wherein a small amount (e.g., 1%) of gaseous oxygen is exposed to wüstite nanoparticles for a defined period of time sufficient to partially oxidize the wüstite but prevent conversion entirely to magnetite. Finally, methods of using the iron oxide nanoparticles are also provided. Representative methods include magnetic particle imaging, magnetic resonance imaging, and hyperthermia.

    摘要翻译： 本文公开了具有处于亚稳态的铁（II）含量的铁氧化物纳米粒子，其处于亚稳铁矿和磁铁矿的铁（II）含量中间。 所公开的氧化铁纳米颗粒显示出由纳米颗粒的尺寸和铁（II）含量两者导致的出人意料的有利磁性（例如，饱和磁化）。 因此，氧化铁纳米粒子对于磁性成像应用如磁性粒子成像具有吸引力。 还提供了形成氧化铁纳米颗粒的方法，这些方法包括控制氧化步骤，其中将少量（例如1％）的气态氧暴露于硅石纳米颗粒达限定的时间段，以足以部分氧化硅灰石但防止 完全转化为磁铁矿。 最后，还提供了使用氧化铁纳米颗粒的方法。 代表性的方法包括磁性粒子成像，磁共振成像和热疗。