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公开(公告)号：EP3339319B1
公开(公告)日：2019-10-16
申请号：EP16904146.4
申请日：2016-07-22
发明人： LEE, Sun Kyo , RYU, Han Bong , LEE, Seong Ran , CHOI, Jong Nam , KIM, Tae Hyun , CHOI, Tae Won , JEONG, Tae Hwa , KWON, Hyeong Il
IPC分类号： C07K14/485 , C07K14/435 , C12N15/62 , A61K8/64 , A61Q19/00
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公开(公告)号：EP3299385B1
公开(公告)日：2019-09-11
申请号：EP16904720.6
申请日：2016-07-22
发明人： LEE, Sun Kyo , RYU, Han Bong , LEE, Seong Ran , CHOI, Jong Nam , CHOI, Tae Won , KIM, Tae Hyun , JEONG, Tae Hwa , KWON, Hyeong Il
IPC分类号： C12N15/62 , C07K14/485 , C12N9/52 , A61K8/64 , A61Q19/00
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公开(公告)号：EP3339319A1
公开(公告)日：2018-06-27
申请号：EP16904146.4
申请日：2016-07-22
发明人： LEE, Sun Kyo , RYU, Han Bong , LEE, Seong Ran , CHOI, Jong Nam , KIM, Tae Hyun , CHOI, Tae Won , JEONG, Tae Hwa , KWON, Hyeong Il
IPC分类号： C07K14/485 , C07K14/435 , C12N15/62 , A61K8/64 , A61Q19/00
摘要： The present invention relates to a thermostable human epidermal growth factor-spider venom fusion protein with increased skin cell proliferation effect which consists of the amino acid sequence of SEQ ID NO: 2, a gene consisting of E. coli ( Escherichia coli ) codon-optimized nucleotide sequence of SEQ ID NO: 1 for encoding the aforementioned human epidermal growth factor-spider venom fusion protein, a recombinant vector comprising the aforementioned gene, a host cell transformed with the aforementioned recombinant vector, and a method for producing in a host cell a human epidermal growth factor-spider venom fusion protein by transforming a host cell with the aforementioned recombinant vector, and a cosmetic composition for improving skin wrinkle and maintaining skin elasticity comprising, as an effective component, a human epidermal growth factor-spider venom fusion protein, and as the cosmetic composition of the present invention has excellent thermostability and has an effect of enhancing the activity of improving skin wrinkle and maintaining skin elasticity, it can be advantageously used in future in the field of cosmetics or cosmetic plastic surgery.
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4.发明公开BOTULINUM TOXIN-HUMAN EPIDERMAL GROWTH FACTOR FUSION PROTEIN HAVING IMPROVED SKIN CELL PROLIFERATION AND ANTIOXIDANT EFFECT, AND COSMETIC COMPOSITION CONTAINING SAME AS EFFECTIVE INGREDIENT FOR SKIN REGENERATION AND WRINKLE IMPROVEMENT 有权具有改善皮肤细胞增殖和抗氧化作用的肉毒杆菌毒素 - 人表皮生长因子融合蛋白，以及含有用于皮肤再生和改善皱纹的有效成分的化妆品组合物
公开(公告)号：EP3299385A1
公开(公告)日：2018-03-28
申请号：EP16904720.6
申请日：2016-07-22
发明人： LEE, Sun Kyo , RYU, Han Bong , LEE, Seong Ran , CHOI, Jong Nam , CHOI, Tae Won , KIM, Tae Hyun , JEONG, Tae Hwa , KWON, Hyeong Il
CPC分类号： C12N9/52 , A61K8/64 , A61K8/66 , A61K38/18 , A61K38/48 , A61Q19/00 , A61Q19/08 , C07K14/33 , C07K14/485 , C07K2319/55 , C07K2319/75 , C12N15/62 , C12N15/70 , C12Y304/24069
摘要： The present invention relates to a botulinum toxin-human epidermal growth factor fusion protein with increased skin cell proliferation and anti-oxidation effect which consists of the amino acid sequence of SEQ ID NO: 2, a gene consisting of E. coli ( Escherichia coli ) codon-optimized nucleotide sequence of SEQ ID NO: 1 for encoding the botulinum toxin-human epidermal growth factor fusion protein, a recombinant vector comprising the aforementioned gene, a host cell transformed with the aforementioned recombinant vector, and a method for producing a botulinum toxin-human epidermal growth factor fusion protein by transforming a host cell with the aforementioned recombinant vector, and a cosmetic composition for regenerating skin and improving skin wrinkle comprising, as an effective component, a botulinum toxin-human epidermal growth factor fusion protein, and as the cosmetic composition of the present invention has an effect of regenerating skin and improving skin wrinkle, it can be advantageously used in future in the field of cosmetics or cosmetic plastic surgery.
摘要翻译： 本发明涉及具有增加的皮肤细胞增殖和抗氧化作用的肉毒杆菌毒素 - 人表皮生长因子融合蛋白，其由SEQ ID NO：2的氨基酸序列，由大肠杆菌（Escherichia coli）组成的基因， 用于编码肉毒杆菌毒素 - 人表皮生长因子融合蛋白的SEQ ID NO：1的密码子优化的核苷酸序列，包含上述基因的重组载体，用上述重组载体转化的宿主细胞以及肉毒杆菌毒素的生产方法 通过用上述重组载体转化宿主细胞来获得人表皮生长因子融合蛋白，以及用于再生皮肤和改善皮肤皱纹的化妆品组合物，其包含作为有效成分的肉毒杆菌毒素 - 人表皮生长因子融合蛋白，以及作为 本发明的化妆品组合物具有再生皮肤和改善皮肤皱纹的作用，它可以是更好的 将来在化妆品或美容整形外科领域中将被严格使用。
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