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公开(公告)号：EP3632922A1
公开(公告)日：2020-04-08
申请号：EP17911012.7
申请日：2017-06-01
发明人： LEE, Sun Kyo , LEE, Seong Ran , RYU, Han Bong , KIM, Tae Hyun , CHOI, Tae Won , KWON, Hyeong Il , ROH, Woo Yeon
IPC分类号： C07K14/00 , C07K14/425 , A61K8/64 , A61Q19/08 , C12N15/70
摘要： The present invention relates to a fusion protein comprising heat shock protein 10 and brazzein protein which has an enhanced anti-oxidation activity and skin cell proliferation effect, and a cosmetic composition for ameliorating skin wrinkles, which contains the fusion protein as an effective component, in which the cosmetic composition according to the present invention can be advantageously used in future as a material of a functional cosmetic product.
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公开(公告)号：EP3505532A1
公开(公告)日：2019-07-03
申请号：EP17843987.3
申请日：2017-08-25
发明人： LEE, Sun Kyo
IPC分类号： C07K14/47 , C07K14/435 , C12N15/62 , C12N15/70 , C12P21/00 , A61K8/64 , A61Q19/00 , A61Q19/08
摘要： The present invention relates to a scorpion toxin fusion protein with enhanced skin cell proliferation effect and a cosmetic composition comprising, as an effective ingredient, the scorpion toxin fusion protein for improving skin wrinkle, skin elasticity, and anti-aging. Because the cosmetic composition of the present invention has an excellent cell proliferation effect and an effect of improving skin wrinkle and enhancing skin elasticity, it is expected to be used advantageously in the field of functional cosmetics.
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3.发明公开BOTULINUM TOXIN-HUMAN EPIDERMAL GROWTH FACTOR FUSION PROTEIN HAVING IMPROVED SKIN CELL PROLIFERATION AND ANTIOXIDANT EFFECT, AND COSMETIC COMPOSITION CONTAINING SAME AS EFFECTIVE INGREDIENT FOR SKIN REGENERATION AND WRINKLE IMPROVEMENT 有权具有改善皮肤细胞增殖和抗氧化作用的肉毒杆菌毒素 - 人表皮生长因子融合蛋白，以及含有用于皮肤再生和改善皱纹的有效成分的化妆品组合物
公开(公告)号：EP3299385A1
公开(公告)日：2018-03-28
申请号：EP16904720.6
申请日：2016-07-22
发明人： LEE, Sun Kyo , RYU, Han Bong , LEE, Seong Ran , CHOI, Jong Nam , CHOI, Tae Won , KIM, Tae Hyun , JEONG, Tae Hwa , KWON, Hyeong Il
CPC分类号： C12N9/52 , A61K8/64 , A61K8/66 , A61K38/18 , A61K38/48 , A61Q19/00 , A61Q19/08 , C07K14/33 , C07K14/485 , C07K2319/55 , C07K2319/75 , C12N15/62 , C12N15/70 , C12Y304/24069
摘要： The present invention relates to a botulinum toxin-human epidermal growth factor fusion protein with increased skin cell proliferation and anti-oxidation effect which consists of the amino acid sequence of SEQ ID NO: 2, a gene consisting of E. coli ( Escherichia coli ) codon-optimized nucleotide sequence of SEQ ID NO: 1 for encoding the botulinum toxin-human epidermal growth factor fusion protein, a recombinant vector comprising the aforementioned gene, a host cell transformed with the aforementioned recombinant vector, and a method for producing a botulinum toxin-human epidermal growth factor fusion protein by transforming a host cell with the aforementioned recombinant vector, and a cosmetic composition for regenerating skin and improving skin wrinkle comprising, as an effective component, a botulinum toxin-human epidermal growth factor fusion protein, and as the cosmetic composition of the present invention has an effect of regenerating skin and improving skin wrinkle, it can be advantageously used in future in the field of cosmetics or cosmetic plastic surgery.
摘要翻译： 本发明涉及具有增加的皮肤细胞增殖和抗氧化作用的肉毒杆菌毒素 - 人表皮生长因子融合蛋白，其由SEQ ID NO：2的氨基酸序列，由大肠杆菌（Escherichia coli）组成的基因， 用于编码肉毒杆菌毒素 - 人表皮生长因子融合蛋白的SEQ ID NO：1的密码子优化的核苷酸序列，包含上述基因的重组载体，用上述重组载体转化的宿主细胞以及肉毒杆菌毒素的生产方法 通过用上述重组载体转化宿主细胞来获得人表皮生长因子融合蛋白，以及用于再生皮肤和改善皮肤皱纹的化妆品组合物，其包含作为有效成分的肉毒杆菌毒素 - 人表皮生长因子融合蛋白，以及作为 本发明的化妆品组合物具有再生皮肤和改善皮肤皱纹的作用，它可以是更好的 将来在化妆品或美容整形外科领域中将被严格使用。
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4.发明公开SV82 POLYPEPTIDE, AND COSMETIC COMPOSITION FOR REDUCING SKIN WRINKLES AND MAINTAINING SKIN ELASTICITY COMPRISING SV82 POLYPEPTIDE AS ACTIVE INGREDIENT 审中-公开SV82多肽以及用于减少皮肤皱纹和保持皮肤弹性的化妆品组合物，其包含作为活性成分的SV82多肽
公开(公告)号：EP3187167A1
公开(公告)日：2017-07-05
申请号：EP16195913.5
申请日：2016-10-27
发明人： LEE, Sun Kyo , YOO, Je Geun , LEE, Seong Ran , RYU, Han Bong , CHOI, Tae Won , CHOI, Jong Nam , KIM, Tae Hyun
CPC分类号： C07K14/43518 , A61K8/0216 , A61K8/64 , A61Q19/08
摘要： Provided are a spider venom (SV) 82 polypeptide having an amino acid sequence of SEQ ID NO: 2, a SV82 polypeptide-encoding gene having a nucleotide sequence of SEQ ID NO: 1 which is optimized for E. coli codon, a recombinant vector comprising the SV82 polypeptide-encoding gene, a E. coli transformed with the recombinant vector, a method of producing SV82 polypeptide by transforming a host cell with the recombinant vector, and a cosmetic composition for reducing skin wrinkles and maintaining skin elasticity comprising SV82 polypeptide as an active ingredient.
摘要翻译： 提供了具有SEQ ID NO：2的氨基酸序列的蜘蛛毒液（SV）82多肽，具有针对大肠杆菌密码子优化的SEQ ID NO：1的核苷酸序列的SV82多肽编码基因，重组载体 包含SV82多肽编码基因，用该重组载体转化的大肠杆菌，用重组载体转化宿主细胞生产SV82多肽的方法，以及用于减少皮肤皱纹并保持皮肤弹性的化妆品组合物，其包含SV82多肽 一种有效成分。
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公开(公告)号：EP1730278A4
公开(公告)日：2007-07-11
申请号：EP04725553
申请日：2004-04-02
发明人： LEE SUN , YOO JAE-GEUN , CHANG SUXO
CPC分类号： C07K14/461 , C07K2319/20 , C12N15/62 , C12N15/8257
摘要： The present invention relates to a method for the production, isolation, and purification of a recombinant protein, more particularly, to a method for isolating and purifying a foreign protein stably using Anti-Freeze Protein (AFP), thereby producing the protein. The present invention provides a method for the production, isolation and purification of a foreign target protein using its recombinant protein containing AFP, and a construct, an expression vector, a transformant and a recombinant protein. The recombinant protein produced by the present invention shows the biological property and function identical to a naturally occurring protein. Particularly, the present invention is advantageous for the expression and purification of a useful protein.
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公开(公告)号：EP1730278A1
公开(公告)日：2006-12-13
申请号：EP04725553.4
申请日：2004-04-02
发明人： LEE, Sun , YOO, Jae-Geun , CHANG, Suxo
CPC分类号： C07K14/461 , C07K2319/20 , C12N15/62 , C12N15/8257
摘要： The present invention relates to a method for the production, isolation, and purification of a recombinant protein, more particularly, to a method for isolating and purifying a foreign protein stably using Anti-Freeze Protein (AFP), thereby producing the protein. The present invention provides a method for the production, isolation and purification of a foreign target protein using its recombinant protein containing AFP, and a construct, an expression vector, a transformant and a recombinant protein. The recombinant protein produced by the present invention shows the biological property and function identical to a naturally occurring protein. Particularly, the present invention is advantageous for the expression and purification of a useful protein.
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公开(公告)号：EP3299385B1
公开(公告)日：2019-09-11
申请号：EP16904720.6
申请日：2016-07-22
发明人： LEE, Sun Kyo , RYU, Han Bong , LEE, Seong Ran , CHOI, Jong Nam , CHOI, Tae Won , KIM, Tae Hyun , JEONG, Tae Hwa , KWON, Hyeong Il
IPC分类号： C12N15/62 , C07K14/485 , C12N9/52 , A61K8/64 , A61Q19/00
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公开(公告)号：EP3521306A1
公开(公告)日：2019-08-07
申请号：EP17856587.5
申请日：2017-08-31
发明人： LEE, Sun Kyo , KIM, Tae Hyun , LEE, Seong Ran , RYU, Han Bong , CHOI, Tae Won , KWON, Hyeong Il , ROH, Woo Yeon , LEE, Sun Kyo
摘要： The present invention relates to a cosmetic composition for improving skin wrinkle with increased anti-oxidant activity and skin cell proliferation effect comprising, as an effective component, a fusion protein of antifreeze protein and human epidermal growth factor, and, as the fusion protein of the present invention has an excellent anti-oxidant activity and a high skin cell proliferation effect, it can be advantageously used as a raw material of a functional cosmetic having an excellent skin regeneration effect like improvement of skin wrinkles and skin whitening.
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公开(公告)号：EP3339319A1
公开(公告)日：2018-06-27
申请号：EP16904146.4
申请日：2016-07-22
发明人： LEE, Sun Kyo , RYU, Han Bong , LEE, Seong Ran , CHOI, Jong Nam , KIM, Tae Hyun , CHOI, Tae Won , JEONG, Tae Hwa , KWON, Hyeong Il
IPC分类号： C07K14/485 , C07K14/435 , C12N15/62 , A61K8/64 , A61Q19/00
摘要： The present invention relates to a thermostable human epidermal growth factor-spider venom fusion protein with increased skin cell proliferation effect which consists of the amino acid sequence of SEQ ID NO: 2, a gene consisting of E. coli ( Escherichia coli ) codon-optimized nucleotide sequence of SEQ ID NO: 1 for encoding the aforementioned human epidermal growth factor-spider venom fusion protein, a recombinant vector comprising the aforementioned gene, a host cell transformed with the aforementioned recombinant vector, and a method for producing in a host cell a human epidermal growth factor-spider venom fusion protein by transforming a host cell with the aforementioned recombinant vector, and a cosmetic composition for improving skin wrinkle and maintaining skin elasticity comprising, as an effective component, a human epidermal growth factor-spider venom fusion protein, and as the cosmetic composition of the present invention has excellent thermostability and has an effect of enhancing the activity of improving skin wrinkle and maintaining skin elasticity, it can be advantageously used in future in the field of cosmetics or cosmetic plastic surgery.
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公开(公告)号：EP3617225A1
公开(公告)日：2020-03-04
申请号：EP17906822.6
申请日：2017-08-01
发明人： LEE, Sun Kyo , LEE, Seong Ran , RYU, Han Bong , KIM, Tae Hyun , CHOI, Tae Won
摘要： The present invention relates to a fusion protein of heat shock proteins which has an increased anti-oxidant activity and skin cell proliferation effect and an anti-wrinkle composition which comprises the fusion protein as an effective component, and the cosmetic composition according to the present invention can be advantageously used in future as a material of a functional cosmetic product.
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