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公开(公告)号：EP2254880A2
公开(公告)日：2010-12-01
申请号：EP09713314.4
申请日：2009-02-23
发明人： HECK, James , WINSSINGER, Nicolas , CHABALA, John C. , BARLUENGA, Sofia , CHEN, Ruihong , RUBENSTEIN, Allan , YU, Jin-Chen
IPC分类号： C07D313/00 , C07D315/00 , A61K31/365
CPC分类号： C07D313/00
摘要： The present invention includes macrocyclic prodrug compounds, pharmaceutical compositions containing them. The present invention also includes use of these compounds in the treatment of various diseases including an autoimmune disease, an inflammatory disease, a neurological or neurodegenerative disease, cancer, a cardiovascular disease, allergy, asthma, a hormone-related disease, and tumors or symptoms resulting from neurofibromatosis.
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2.发明公开SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS 有权所产生的合成作为合适THERAPEUTICS二羟基苯甲酸内酯的
公开(公告)号：EP2242359A1
公开(公告)日：2010-10-27
申请号：EP09702521.7
申请日：2009-01-15
CPC分类号： C07D313/00 , A61K31/335 , A61K31/365 , A61K31/4025 , A61K31/435 , A61K31/4453 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D211/14 , C07D225/06 , C07D405/12 , C07D405/14 , Y02P20/55
摘要： Disclosed are macrocyclic compounds of formulae I, I', II, II', III, III', IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.
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公开(公告)号：EP2254880B1
公开(公告)日：2016-08-17
申请号：EP09713314.4
申请日：2009-02-23
发明人： HECK, James , WINSSINGER, Nicolas , CHABALA, John C. , BARLUENGA, Sofia , CHEN, Ruihong , RUBENSTEIN, Allan , YU, Jin-Chen
IPC分类号： C07D313/00 , C07D315/00 , A61K31/365
CPC分类号： C07D313/00
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