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公开(公告)号：EP2254880B1
公开(公告)日：2016-08-17
申请号：EP09713314.4
申请日：2009-02-23
发明人： HECK, James , WINSSINGER, Nicolas , CHABALA, John C. , BARLUENGA, Sofia , CHEN, Ruihong , RUBENSTEIN, Allan , YU, Jin-Chen
IPC分类号： C07D313/00 , C07D315/00 , A61K31/365
CPC分类号： C07D313/00
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2.发明授权SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS 有权所产生的合成作为合适THERAPEUTICS二羟基苯甲酸内酯的
公开(公告)号：EP2242359B1
公开(公告)日：2016-06-01
申请号：EP09702521.7
申请日：2009-01-15
IPC分类号： A01N31/14 , A61K31/02 , C07D313/00 , C07D405/12 , C07D405/14
CPC分类号： C07D313/00 , A61K31/335 , A61K31/365 , A61K31/4025 , A61K31/435 , A61K31/4453 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D211/14 , C07D225/06 , C07D405/12 , C07D405/14 , Y02P20/55
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公开(公告)号：EP2254880B8
公开(公告)日：2016-09-21
申请号：EP09713314.4
申请日：2009-02-23
发明人： HECK, James , WINSSINGER, Nicolas , CHABALA, John C. , BARLUENGA, Sofia , CHEN, Ruihong , RUBENSTEIN, Allan , YU, Jin-Chen
IPC分类号： C07D313/00 , C07D315/00 , A61K31/365
CPC分类号： C07D313/00
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公开(公告)号：EP2446033A2
公开(公告)日：2012-05-02
申请号：EP10752168.4
申请日：2010-06-22
CPC分类号： C12Q1/6837 , C12N15/1068 , C40B40/06 , C40B50/04
摘要： A method for identifying one or several molecular structure(s) having a high-affinity for a target of interest, said molecular structure(s) each comprising one nucleotide chain onto which is hybridized at least one PNA-encoded molecule.
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5.发明公开POCHOXIME CONJUGATES USEFUL FOR THE TREATMENT OF HSP90 RELATED PATHOLOGIES 审中-公开POCHOXIMKONJUGATE为疾病相关的HSP90治疗
公开(公告)号：EP2630132A1
公开(公告)日：2013-08-28
申请号：EP11797116.8
申请日：2011-10-24
IPC分类号： C07D313/00 , C07D495/04 , C07H15/26 , A61K31/335 , A61K31/7048 , A61P35/00
CPC分类号： C07D405/12 , A61K31/4523 , A61K31/454 , A61K31/706 , C07D313/00 , C07D405/14 , C07D495/04 , C07H15/26
摘要： The present invention includes novel derivatives, analogs, and intermediates of the natural products radicicol, pochonins, pochoximes, and their syntheses. The present invention also provides a pharamceutical composition comprising the present compound and the use of the compound as inhibitors of kinases and of the enzyme family known as heat shock protein 90 (HSP90).
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公开(公告)号：EP2446033B1
公开(公告)日：2013-10-23
申请号：EP10752168.4
申请日：2010-06-22
CPC分类号： C12Q1/6837 , C12N15/1068 , C40B40/06 , C40B50/04
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7.发明公开IRREVERSIBLE INHIBITORS USEFUL FOR THE TREATMENT OF KINASE-RELATED PATHOLOGIES 审中-公开不可逆抑制剂来治疗激酶相关疾病
公开(公告)号：EP2483259A1
公开(公告)日：2012-08-08
申请号：EP10760324.3
申请日：2010-09-28
IPC分类号： C07D313/00 , A61K31/335 , A61P35/00
CPC分类号： C07D313/00
摘要： The present invention provides new compounds (I) having a kinase inhibitory activity and useful for treating cancer.
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公开(公告)号：EP2254880A2
公开(公告)日：2010-12-01
申请号：EP09713314.4
申请日：2009-02-23
发明人： HECK, James , WINSSINGER, Nicolas , CHABALA, John C. , BARLUENGA, Sofia , CHEN, Ruihong , RUBENSTEIN, Allan , YU, Jin-Chen
IPC分类号： C07D313/00 , C07D315/00 , A61K31/365
CPC分类号： C07D313/00
摘要： The present invention includes macrocyclic prodrug compounds, pharmaceutical compositions containing them. The present invention also includes use of these compounds in the treatment of various diseases including an autoimmune disease, an inflammatory disease, a neurological or neurodegenerative disease, cancer, a cardiovascular disease, allergy, asthma, a hormone-related disease, and tumors or symptoms resulting from neurofibromatosis.
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