公开(公告)号：EP1452528B1

公开(公告)日：2008-08-13

申请号：EP02780099.4

申请日：2002-11-14

申请人： NIPPON CHEMIPHAR CO., LTD.

发明人： YOSHIDA, Shinichi ,  TENDO, Atsushi ,  KOBAYASHI, Kunio ,  MOCHIDUKI, Nobutaka ,  YAMAKAWA, Tomio ,  SHINOHARA, Yoriko

IPC分类号： C07D235/18 ,  C07D263/56 ,  C07D277/66 ,  C07D471/04 ,  C07D473/30 ,  C07D473/34 ,  C07D473/40 ,  C07D498/04 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  A61P9/00

CPC分类号： C07D263/57 ,  C07D235/18 ,  C07D277/66 ,  C07D401/14 ,  C07D471/04 ,  C07D473/00 ,  C07D473/30 ,  C07D473/34 ,  C07D473/40 ,  C07D487/04 ,  C07D513/04

摘要： Compounds represented by the general formula (I), and xanthine oxidase inhibitors containing the same as the active ingredient: (I) wherein R1 is OR4 or the like (wherein R4 is optionally substituted C1-8 alkyl or the like); R2 is halogeno, nitro, cyano, carboxyl, or the like; R3 is hydrogen, halogeno, hydroxyl, amino, carboxyl, or the like; X is NR11, oxygen, or sulfur (wherein R11 is hydrogen or optionally substituted C1-8 alkyl); and Y and Z are each CR12 or nitrogen (wherein R12 is the same as defined for R3).

公开(公告)号：EP1452528A1

公开(公告)日：2004-09-01

申请号：EP02780099.4

申请日：2002-11-14

申请人： NIPPON CHEMIPHAR CO., LTD.

发明人： YOSHIDA, Shinichi ,  TENDO, Atsushi ,  KOBAYASHI, Kunio ,  MOCHIDUKI, Nobutaka ,  YAMAKAWA, Tomio ,  SHINOHARA, Yoriko

IPC分类号： C07D235/18 ,  C07D263/56 ,  C07D277/66 ,  C07D471/04 ,  C07D473/30 ,  C07D473/34 ,  C07D473/40 ,  C07D498/04 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  A61K31/437 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61P3/00 ,  A61P13/12 ,  A61P19/06 ,  A61P43/00

CPC分类号： C07D263/57 ,  C07D235/18 ,  C07D277/66 ,  C07D401/14 ,  C07D471/04 ,  C07D473/00 ,  C07D473/30 ,  C07D473/34 ,  C07D473/40 ,  C07D487/04 ,  C07D513/04

摘要： The invention relates to compounds of the following formula (I) or their salts:
in which R 1 represents OR 4 or others, in which R 4 is an alkyl group having 1-8 carbon atoms which may have a substituent or the like; R 2 is halogen, nitro, cyano, carboxyl, or the like; R 3 is hydrogen, halogen, hydroxyl, amino, carboxyl, or the like; X is NR 11 , oxygen, or sulfur, in which R 11 is hydrogen, or an alkyl group having 1-8 carbon atom which may have a substituent; and each of Y and Z is CR 12 or nitrogen, in which R 12 has the same meaning as R 3 above, and a xanthine oxidase inhibitor containing the compound as an active ingredient.

摘要翻译： 本发明涉及下式（I）的化合物或其盐：其中R 1表示OR 4或其它的其中R 4为具有1-8个碳原子的烷基的CHEM 可以具有取代基等; R 2是卤素，硝基，氰基，羧基等; R 3是氢，卤素，羟基，氨基，羧基等; X是NR 11，氧或硫，其中R 11是氢，或具有1-8个碳原子的可以具有取代基的烷基; Y和Z各自为CR 12或氮，其中R 12具有与上述R 3相同的含义，和含有该化合物作为活性成分的黄嘌呤氧化酶抑制剂。

公开(公告)号：EP1757610B1

公开(公告)日：2011-06-08

申请号：EP05751417.6

申请日：2005-06-13

申请人： Nippon Chemiphar Co., Ltd.

发明人： YOSHIDA, Shinichi ,  KOBAYASHI, Kunio ,  MOCHIDUKI, Nobutaka ,  YAMAKAWA, Tomio ,  KOBAYASHI, Tadashi ,  SHINOHARA, Yoriko

IPC分类号： C07D498/04 ,  A61K31/519 ,  A61P19/06 ,  A61P43/00 ,  C07D513/04

CPC分类号： C07D513/04 ,  C07D498/04

摘要： Disclosed is a compound represented by the following general formula (I) (wherein R1 represents an aryl group having 6-10 carbon atoms or a heteroaryl group which may have, as a substituent, a group selected from an alkyl group having 1-8 carbon atoms, an alkyl group having 1-8 carbon atoms which is substituted with a halogen atom, an alkoxy group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms which is substituted with an alkoxy group having 1-8 carbon atoms, an alkoxycarbonyl group having 2-8 carbon atoms, a formyl group, a carboxyl group, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an aryl group having 6-10 carbon atoms and an aryloxy group having 6-10 carbon atoms; R2 represents a cyano group, a nitro group or the like; R3 represents an hydroxyl group or the like; X represents an oxygen atom, a sulfur atom or the like; and Y represents an oxygen atom or a sulfur atom). Also disclosed is a xanthine oxidase inhibitor containing such a compound.

公开(公告)号：EP1911760A1

公开(公告)日：2008-04-16

申请号：EP06780819.6

申请日：2006-06-29

申请人： Nippon Chemiphar Co., Ltd.

发明人： NISHINO, Takeshi ,  YOSHIDA, Shinichi ,  TENDO, Atsushi ,  YAMAKAWA, Tomio ,  KOBAYASHI, Tadashi ,  SHINOHARA, Yoriko

IPC分类号： C07D473/00 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/541 ,  A61P19/06 ,  A61P43/00 ,  C07D498/04 ,  C07D513/04

CPC分类号： C07D473/00 ,  C07D498/04 ,  C07D513/04

摘要： A compound represented by the following formula (I) is used as a xanthine oxidase inhibitor:

in which R 1 is phenyl or pyridyl each optionally having, as a substituent, C 1-8 alkyl, C 1-8 haloalkyl, C 1-8 alkoxy, carboxyl, halogeno, hydroxyl, nitro, cyano, amino, etc.; R 2 is cyano, nitro, etc.; X is oxygen, sulfur, etc.; and Y is sulfur, NH, etc.

摘要翻译： 将下式（I）表示的化合物用作黄嘌呤氧化酶抑制剂：其中R 1为苯基或吡啶基，每个任选具有C 1-8烷基，C 1-8卤代烷基，C 1-8烷基 烷氧基，羧基，卤代，羟基，硝基，氰基，氨基等; R 2是氰基，硝基等; X是氧，硫等; Y为硫，NH等

公开(公告)号：EP1757610A1

公开(公告)日：2007-02-28

申请号：EP05751417.6

申请日：2005-06-13

申请人： Nippon Chemiphar Co., Ltd.

发明人： YOSHIDA, Shinichi ,  KOBAYASHI, Kunio ,  MOCHIDUKI, Nobutaka ,  YAMAKAWA, Tomio ,  KOBAYASHI, Tadashi ,  SHINOHARA, Yoriko

IPC分类号： C07D498/04 ,  A61K31/519 ,  A61P19/06 ,  A61P43/00 ,  C07D513/04

CPC分类号： C07D513/04 ,  C07D498/04

摘要： The invention relates to compounds of the following formula (I) or their salts:

in which R 1 is a group of phenyl, naphthyl, pyridyl or the like which may have a substituent such as an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkoxycarbonyl group having 2-8 carbon atoms, carboxyl, halogen, hydroxyl, nitro, or cyano; R 2 is cyano, nitro, or the like; R 3 is hydroxyl or the like; X is oxygen, sulfur, or the like; and Y is oxygen or sulfur, and a xanthine oxidase inhibitor containing the compound.

摘要翻译： 本发明涉及下式（I）的化合物或其盐：其中R 1是可具有取代基的苯基，萘基，吡啶基等基团，例如具有1-8个碳原子的烷基， 具有1-8个碳原子的烷氧基，具有2-8个碳原子的烷氧基羰基，羧基，卤素，羟基，硝基或氰基; R 2是氰基，硝基等; R 3是羟基等; X是氧，硫等; Y为氧或硫，含有该化合物的黄嘌呤氧化酶抑制剂。