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10 条记录 (耗时 0.015 秒)

    CONDENSED PYRIMIDINE DERIVATIVE AND XANTHINE OXIDASE INHIBITOR
    1.
    发明授权
    CONDENSED PYRIMIDINE DERIVATIVE AND XANTHINE OXIDASE INHIBITOR 有权
    稠合嘧啶衍生物和黄嘌呤氧化酶抑制剂

    公开(公告)号：EP1757610B1

    公开(公告)日：2011-06-08

    申请号：EP05751417.6

    申请日：2005-06-13

    申请人： Nippon Chemiphar Co., Ltd.

    发明人： YOSHIDA, Shinichi ,  KOBAYASHI, Kunio ,  MOCHIDUKI, Nobutaka ,  YAMAKAWA, Tomio ,  KOBAYASHI, Tadashi ,  SHINOHARA, Yoriko

    IPC分类号： C07D498/04 ,  A61K31/519 ,  A61P19/06 ,  A61P43/00 ,  C07D513/04

    CPC分类号： C07D513/04 ,  C07D498/04

    摘要： Disclosed is a compound represented by the following general formula (I) (wherein R1 represents an aryl group having 6-10 carbon atoms or a heteroaryl group which may have, as a substituent, a group selected from an alkyl group having 1-8 carbon atoms, an alkyl group having 1-8 carbon atoms which is substituted with a halogen atom, an alkoxy group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms which is substituted with an alkoxy group having 1-8 carbon atoms, an alkoxycarbonyl group having 2-8 carbon atoms, a formyl group, a carboxyl group, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, an aryl group having 6-10 carbon atoms and an aryloxy group having 6-10 carbon atoms; R2 represents a cyano group, a nitro group or the like; R3 represents an hydroxyl group or the like; X represents an oxygen atom, a sulfur atom or the like; and Y represents an oxygen atom or a sulfur atom). Also disclosed is a xanthine oxidase inhibitor containing such a compound.

    CONDENSED PYRIMIDINE DERIVATIVE AND XANTHINE OXIDASE INHIBITOR
    2.
    发明公开
    CONDENSED PYRIMIDINE DERIVATIVE AND XANTHINE OXIDASE INHIBITOR 有权
    新戊酰氧化酶抑制剂的邻苯二酚

    公开(公告)号：EP1757610A1

    公开(公告)日：2007-02-28

    申请号：EP05751417.6

    申请日：2005-06-13

    申请人： Nippon Chemiphar Co., Ltd.

    发明人： YOSHIDA, Shinichi ,  KOBAYASHI, Kunio ,  MOCHIDUKI, Nobutaka ,  YAMAKAWA, Tomio ,  KOBAYASHI, Tadashi ,  SHINOHARA, Yoriko

    IPC分类号： C07D498/04 ,  A61K31/519 ,  A61P19/06 ,  A61P43/00 ,  C07D513/04

    CPC分类号： C07D513/04 ,  C07D498/04

    摘要： The invention relates to compounds of the following formula (I) or their salts:

    in which R 1 is a group of phenyl, naphthyl, pyridyl or the like which may have a substituent such as an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkoxycarbonyl group having 2-8 carbon atoms, carboxyl, halogen, hydroxyl, nitro, or cyano; R 2 is cyano, nitro, or the like; R 3 is hydroxyl or the like; X is oxygen, sulfur, or the like; and Y is oxygen or sulfur, and a xanthine oxidase inhibitor containing the compound.

    摘要翻译： 本发明涉及下式（I）的化合物或其盐：其中R 1是可具有取代基的苯基，萘基，吡啶基等基团，例如具有1-8个碳原子的烷基， 具有1-8个碳原子的烷氧基，具有2-8个碳原子的烷氧基羰基，羧基，卤素，羟基，硝基或氰基; R 2是氰基，硝基等; R 3是羟基等; X是氧，硫等; Y为氧或硫，含有该化合物的黄嘌呤氧化酶抑制剂。

    ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR
    6.
    发明公开
    ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR 审中-公开
    AKTIVATORFÜRPEROXISOM-PROLIFERATOR-AKTIVIERTE REZEPTOREN

    公开(公告)号：EP1897872A1

    公开(公告)日：2008-03-12

    申请号：EP06756770.1

    申请日：2006-05-24

    申请人： Nippon Chemiphar Co., Ltd.

    发明人： SAKUMA, Shogo ,  MOCHIDUKI, Nobutaka ,  TAKAHASHI, Rie ,  HIRAI, Toshitake ,  YAMAKAWA, Tomio ,  MASUI, Seiichiro

    IPC分类号： C07D277/28 ,  A61K31/496 ,  A61P3/06 ,  A61P43/00

    CPC分类号： C07D277/28

    摘要： A compound having the following formula or its salt is used as an activator for PPAR:

    [in which W 2 represents a bond, C(C=O) or CH 2 ; Z 2 represents an oxygen or sulfur atom; R 21 , R 22 and R 23 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a halogen atom, an alkyl group having 1 to 8 carbon atoms which is substituted with a halogen atom or the like; and R 24 and R 25 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or an alkyl group having 1 to 8 carbon atoms which is substituted with a halogen atom].

    摘要翻译： 具有下式的化合物或其盐用作PPAR的活化剂：[其中W 2表示键，C（C = O）或CH 2; Z 2表示氧或硫原子; R 21，R 22和R 23独立地表示氢原子，碳原子数1〜8的烷基，碳原子数1〜8的烷氧基，卤素原子，碳原子数1〜8的烷基，被取代的 与卤素原子等; R 24和R 25独立地表示氢原子，碳原子数1〜8的烷基或被卤素原子取代的碳原子数1〜8的烷基。