公开(公告)号：EP1325745B1

公开(公告)日：2008-07-23

申请号：EP01974780.7

申请日：2001-10-11

申请人： Nissan Chemical Industries, Ltd. ,  Kowa Company. Ltd.

发明人： KITAHARA, Masaki ,  SAITO, Yasushi ,  MORI, Seijiro ,  TAKEMOTO, Minoru ,  TAMAKI, Taro

IPC分类号： A61K31/47 ,  A61K31/40 ,  A61K31/505 ,  A61K31/22 ,  A61K31/191 ,  A61K31/192 ,  A61P43/00 ,  A61P13/12 ,  A61P25/00 ,  A61P27/02 ,  A61P9/00 ,  A61P3/10 ,  C07D215/14 ,  C07D239/42 ,  C07D207/416

CPC分类号： C07D215/14 ,  A61K31/191 ,  A61K31/192 ,  A61K31/22 ,  A61K31/25 ,  A61K31/40 ,  A61K31/405 ,  A61K31/47 ,  A61K31/505

摘要： Preventives and remedies for complications of diabetes which contain as the active ingredients compounds represented by the following general formula (1) or lactone derivatives thereof: (1) wherein R represents an organic group; X represents CH2CH2- or CH=CH-; and M represents hydrogen, C1-10 alkyl or a physiologically acceptable cationic group. These drugs are useful in preventing and treating complications of diabetes such as diabetic nephropathy, diabetic neuropathy, diabetic retinopathy and diabetic angiopathy.

公开(公告)号：EP1325745A1

公开(公告)日：2003-07-09

申请号：EP01974780.7

申请日：2001-10-11

申请人： Nissan Chemical Industries, Ltd. ,  Kowa Company Ltd.

发明人： KITAHARA, Masaki ,  SAITO, Yasushi ,  MORI, Seijiro ,  TAKEMOTO, Minoru ,  TAMAKI, Taro

IPC分类号： A61K31/47 ,  A61K31/40 ,  A61K31/505 ,  A61K31/22 ,  A61K31/191 ,  A61K31/192 ,  A61P43/00 ,  A61P13/12 ,  A61P25/00 ,  A61P27/02 ,  A61P9/00 ,  A61P3/10 ,  C07D215/14 ,  C07D239/42 ,  C07D207/416

CPC分类号： C07D215/14 ,  A61K31/191 ,  A61K31/192 ,  A61K31/22 ,  A61K31/25 ,  A61K31/40 ,  A61K31/405 ,  A61K31/47 ,  A61K31/505

摘要： The present invention relates to the pharmaceutical useful for the prevention and the treatment of diabetic complications such as diabetic nephropathy, diabetic neuropathy, diabetic retinopathy and diabetic angiopathy among others, and to the prophylaxis and/or treatment drug for diabetic complications with the compound shown in the formula (1)
(wherein R is organic group, X is -CH2CH2- or -CH=CH-, and M is hydrogen atom, C 1-10 alkyl group or physiologically acceptable cation group) or its lactonized form as the active ingredient.

摘要翻译： 本发明涉及所述药物用于预防和糖尿病并发症的治疗中有用：例如糖尿病性肾病，糖尿病性神经病，糖尿病性视网膜病和除其他糖尿病性血管病，以及预防和/或治疗药物，用于与化合物中所示的糖尿病并发症 式（1）（worin R是有机基团，X是-CH 2 CH 2或--CH.dbd.CH--，M是氢原子，C1-10烷基或生理上可接受的阳离子基团）或它的内酯化的形式作为 活性成分。