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    Composition for Enhancing Transdermal Absorption of A Drug and Patch Preparation
    3.
    发明公开
    Composition for Enhancing Transdermal Absorption of A Drug and Patch Preparation 有权
    用于增强药物和贴剂制剂透皮吸收的组合物

    公开(公告)号：EP2570122A1

    公开(公告)日：2013-03-20

    申请号：EP12184302.3

    申请日：2012-09-13

    申请人： NITTO DENKO CORPORATION

    发明人： Okazaki, Arimichi ,  Mukobata, Tsuyoshi ,  Sakamoto, Sachiko ,  Hanatani, Akinori

    IPC分类号： A61K9/70 ,  A61K47/10 ,  A61K9/00

    CPC分类号： A61K9/7061 ,  A61K31/405 ,  Y02A50/481

    摘要： The problem of the present invention is to provide a composition which shows a sufficiently high enhancing effect on transdermal absorption of a drug, particularly, a composition which shows a sufficiently high enhancing effect on transdermal absorption of a drug in a patch preparation.
    A composition for enhancing transdermal absorption of a drug of a patch preparation, containing a higher alcohol having 14 - 20 carbon atoms and a polyvalent alcohol having 3 - 8 carbon atoms.

    摘要翻译： 本发明的课题在于提供对药物的经皮吸收显示出充分高的增强效果的组合物，特别是对贴剂制剂中的药物的透皮吸收显示出充分高的增强效果的组合物。 一种用于增强贴剂制剂药物透皮吸收的组合物，其含有具有14-20个碳原子的高级醇和具有3-8个碳原子的多元醇。

    Manufacturing method of patch preparation
    5.
    发明公开
    Manufacturing method of patch preparation 有权
    Herstellungsverfahren zur Pflasterherstellung

    公开(公告)号：EP2574335A1

    公开(公告)日：2013-04-03

    申请号：EP12186402.9

    申请日：2012-09-27

    申请人： Nitto Denko Corporation

    发明人： Sakamoto, Sachiko ,  Hanatani, Akinori ,  Okazaki, Arimichi ,  Mukobata, Tsuyoshi

    IPC分类号： A61K9/70

    CPC分类号： A61K9/7053 ,  A61K9/7061

    摘要： The present invention aims to provide an economical manufacturing method of a patch preparation that decreases the manufacturing loss, and a manufacturing method of a patch preparation that can provide a patch preparation which has a sufficiently high skin permeation amount of a drug even without increasing the area and thickness of an adhesive layer, wherein precipitation of crystal of the drug is extremely difficult.
    A method of manufacturing a patch preparation 1 comprising:
    pouring a composition for forming an adhesive layer into a container 11 having a concave part 12 with a shape corresponding to a patch preparation to be manufactured, wherein the composition contains a drug, an adhesive polymer and an organic solvent;
    removing the organic solvent from the composition through drying to form a drug-containing adhesive layer 3 in the concave part 12; and
    laminating a support 2 on the drug-containing adhesive layer 3 to give the patch preparation 1 comprising the support 2 and the drug-containing adhesive layer 3 formed on one surface of the support 2.

    摘要翻译： 本发明旨在提供减少制造损失的贴片制剂的经济制造方法以及能够提供具有足够高的药物皮肤透过量的贴剂的贴剂的制造方法，即使不增加面积 和粘合剂层的厚度，其中药物的晶体析出是非常困难的。 制备贴剂的方法1包括：将用于形成粘合剂层的组合物注入具有与要制造的贴片制剂相对应的形状的具有凹形部分12的容器11中，其中所述组合物含有药物，粘合剂聚合物和 有机溶剂; 通过干燥从组合物中除去有机溶剂，以在凹部12中形成含药物的粘合剂层3; 并将载体2层叠在含药物粘合剂层3上，得到包含载体2的贴剂1和形成在载体2的一个表面上的药物含有粘合剂层3。

    Composition for enhancing transdermal absorption of a drug and patch preparation
    8.
    发明公开
    Composition for enhancing transdermal absorption of a drug and patch preparation 有权
    ZUSAMMENSETZUNG ZUR VERBESSERUNG DER TRANSDERMALEN吸收品牌ARZNEIMITTEL- UNDPFLASTERPRÄPARATS

    公开(公告)号：EP2570115A1

    公开(公告)日：2013-03-20

    申请号：EP12184298.3

    申请日：2012-09-13

    申请人： Nitto Denko Corporation

    发明人： Okazaki, Arimichi ,  Mukobata, Tsuyoshi ,  Sakamoto, Sachiko ,  Hanatani, Akinori

    IPC分类号： A61K9/00 ,  A61K9/70

    CPC分类号： A61K9/7038 ,  A61K9/0014 ,  A61K9/7084 ,  A61K31/405 ,  A61K31/41 ,  A61K31/422 ,  A61K31/565

    摘要： The problem of the present invention is to provide a composition for enhancing transdermal absorption of a drug, which shows a sufficiently high enhancing effect on transdermal absorption of a drug, particularly, a composition for enhancing transdermal absorption of a drug, which shows a sufficiently high enhancing effect on transdermal absorption of an acidic drug.
    A composition for enhancing transdermal absorption of a drug, comprising an unsaturated higher alcohol having 12 - 20 carbon atoms and a polyvalent alcohol having 3 - 8 carbon atoms. A composition for enhancing transdermal absorption of a drug, comprising an unsaturated higher alcohol having 12 - 20 carbon atoms, a polyvalent alcohol having 3 - 8 carbon atoms and an organic amine having 2 - 9 carbon atoms.

    摘要翻译： 本发明的问题是提供一种用于增强药物的经皮吸收的组合物，其对药物的透皮吸收具有足够高的增强效果，特别是用于增强药物经皮吸收的组合物，其显示出足够高的 增强对酸性药物经皮吸收的作用。 一种用于增强药物透皮吸收的组合物，其包含具有12-20个碳原子的不饱和高级醇和具有3-8个碳原子的多元醇。 一种用于增强药物的透皮吸收的组合物，其包含具有12-20个碳原子的不饱和高级醇，具有3-8个碳原子的多元醇和具有2-9个碳原子的有机胺。