专利检索 ap:("North Carolina State University") AND inv:"LUO, Michelle" 第 1 页

1.

发明公开
METHODS AND COMPOSITIONS FOR EFFICIENT DELIVERY OF NUCLEIC ACIDS AND RNA-BASED ANTIMICROBIALS 审中-实审

公开(公告)号：EP4299754A3

公开(公告)日：2024-03-20

申请号：EP23192508.2

申请日：2016-06-15

申请人： North Carolina State University

发明人： BEISEL, Chase Lawrence , GOMAA, Ahmed Abdelshafy Mahmoud , LUO, Michelle

IPC分类号： C12N1/21 , C12N7/01 , C12N15/63 , C12P19/34

摘要： The invention relates to the methods for modifying the methylation pattern of bacteriophage DNA and phagemid DNA and to methods for selective killing of bacteria using lysogenic bacteriophages comprising bacteriophage DNA or phagemid DNA comprising components of an engineered CRISPR-Cas system.

2.

发明公开
METHODS AND COMPOSITIONS FOR EFFICIENT DELIVERY OF NUCLEIC ACIDS AND RNA-BASED ANTIMICROBIALS 审中-公开
标题翻译：有效递送核酸和基于RNA的抗微生物剂的方法和组合物

公开(公告)号：EP3307872A1

公开(公告)日：2018-04-18

申请号：EP16812275.2

申请日：2016-06-15

申请人： North Carolina State University

发明人： BEISEL, Chase Lawrence , GOMAA, Ahmed Abdelshafy Mahmoud , LUO, Michelle

IPC分类号： C12N1/21 , C12N7/01 , C12N15/63 , C12P19/34

CPC分类号： C12N15/70 , A01N63/00 , A61K38/00 , A61P31/04 , C12N7/00 , C12N9/1007 , C12N9/22 , C12N9/96 , C12N15/102 , C12N15/11 , C12N2310/20 , C12N2795/10143 , C12N2795/14143 , C12P19/34 , Y02A50/481

摘要： The invention relates to the methods for modifying the methylation pattern of bacteriophage DNA and phagemid DNA and to methods for selective killing of bacteria using lysogenic bacteriophages comprising bacteriophage DNA or phagemid DNA comprising components of an engineered CRISPR-Cas system.

3.

发明公开
METHODS AND COMPOSITIONS FOR EFFICIENT DELIVERY OF NUCLEIC ACIDS AND RNA-BASED ANTIMICROBIALS 审中-公开

公开(公告)号：EP4299754A2

公开(公告)日：2024-01-03

申请号：EP23192508.2

申请日：2016-06-15

申请人： North Carolina State University

发明人： BEISEL, Chase Lawrence , GOMAA, Ahmed Abdelshafy Mahmoud , LUO, Michelle

IPC分类号： C12P19/34

摘要： The invention relates to the methods for modifying the methylation pattern of bacteriophage DNA and phagemid DNA and to methods for selective killing of bacteria using lysogenic bacteriophages comprising bacteriophage DNA or phagemid DNA comprising components of an engineered CRISPR-Cas system.

4.

发明公开
METHODS AND COMPOSITIONS FOR RNA-DIRECTED REPRESSION OF TRANSCRIPTION USING CRISPR-ASSOCIATED GENES 审中-公开
标题翻译：方法和组合物RNA AGERICHTETEN转录抑制BY CRISPR相关基因

公开(公告)号：EP3129490A2

公开(公告)日：2017-02-15

申请号：EP15776563.7

申请日：2015-04-07

申请人： North Carolina State University

发明人： BEISEL, Chase , LUO, Michelle

IPC分类号： C12N15/79

CPC分类号： A61K48/005 , C12N9/22 , C12N15/102 , C12N15/111 , C12N15/63 , C12N15/72 , C12N2310/20 , C12N2320/30

摘要： The present invention is directed to methods and compositions for targeted gene silencing that provide the ability to not only repress expression but to modulate the repression of expression of one or more target genes.

摘要翻译： 本发明涉及方法和组合物用于靶向基因沉默也提供不仅抑制表达，但以调节一种或多种靶基因的表达的抑制的能力。在一个方面，提供了一种重组核酸分子，其包含编码CRISPR-CAS多肽或功能性片段的其子集的核苷酸序列，从I型CRISPR-CAS系统。在一些方面，本发明的重组核酸包括具有基本同一性于I型级联编码多肽的三个或更多个I型级联多肽的核苷酸序列。