公开(公告)号：EP3634967A1

公开(公告)日：2020-04-15

申请号：EP18737718.9

申请日：2018-06-07

申请人： Novartis AG

发明人： CHOI, Ha-Soon ,  JIANG, Jiqing ,  LAJINESS, James Paul ,  NGUYEN, Bao ,  PETRASSI, Hank Michael James ,  WANG, Zhicheng

IPC分类号： C07D493/08 ,  A61K31/444 ,  A61K31/4427 ,  A61P19/02

公开(公告)号：EP2751102B1

公开(公告)日：2019-03-27

申请号：EP12756879.8

申请日：2012-08-28

申请人： Novartis AG

发明人： YEH, Vince ,  LI, Xiaolin ,  LIU, Xiaodong ,  LOREN, Jon ,  MOLTENI, Valentina ,  NABAKKA, Juliet ,  NGUYEN, Bao ,  PETRASSI, Hank Michael James

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P29/00 ,  A61P3/00 ,  A61P17/00 ,  A61P11/00

公开(公告)号：EP3915994A1

公开(公告)日：2021-12-01

申请号：EP21178695.9

申请日：2018-06-07

申请人： Novartis AG

发明人： CHOI, Ha-Soon ,  JIANG, Jiqing ,  LAJINESS, James Paul ,  NGUYEN, Bao ,  PETRASSI, Hank Michael James ,  WANG, Zhicheng

IPC分类号： C07D493/08 ,  A61K31/444 ,  A61K31/4427 ,  A61P19/02

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof;

or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.

公开(公告)号：EP4299123A3

公开(公告)日：2024-04-03

申请号：EP23203447.0

申请日：2018-06-07

申请人： Novartis AG

发明人： CHOI, Ha-Soon ,  JIANG, Jiqing ,  LAJINESS, James Paul ,  NGUYEN, Bao ,  PETRASSI, Hank Michael James ,  WANG, Zhicheng

IPC分类号： C07D493/08 ,  A61K45/06 ,  A61P19/02

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof;

or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.

公开(公告)号：EP4299123A2

公开(公告)日：2024-01-03

申请号：EP23203447.0

申请日：2018-06-07

申请人： Novartis AG

发明人： CHOI, Ha-Soon ,  JIANG, Jiqing ,  LAJINESS, James Paul ,  NGUYEN, Bao ,  PETRASSI, Hank Michael James ,  WANG, Zhicheng

IPC分类号： A61P19/02

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof;

or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.

公开(公告)号：EP3143026A1

公开(公告)日：2017-03-22

申请号：EP15727117.2

申请日：2015-05-12

申请人： Novartis AG

发明人： CHOI, Ha-Soon ,  LAJINESS, James Paul ,  NATALA, Srinivasa Reddy ,  NGUYEN, Bao ,  PETRASSI, Hank Michael James ,  WANG, Zhicheng

IPC分类号： C07D491/18 ,  C07D493/08 ,  A61K31/352 ,  A61K31/44 ,  A61K31/415 ,  A61K31/4245 ,  A61K31/506 ,  A61P19/02

CPC分类号： A61K31/443 ,  A61K31/34 ,  A61K31/351 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4245 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4525 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  A61L27/54 ,  A61L2300/412 ,  A61L2430/06 ,  C07D491/18 ,  C07D493/08 ,  C12N5/0655 ,  C12N2501/999 ,  C12N2506/1346

摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.

摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物，以及使用这些化合物治疗哺乳动物的关节损伤或关节损伤以及诱导间充质干细胞分化为软骨细胞的方法。