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公开(公告)号：EP4251208A1
公开(公告)日：2023-10-04
申请号：EP21827762.2
申请日：2021-11-23
发明人： CHEN, Zhuoliang , D'ALESSIO, Joseph, Anthony , KLINTER, Claudia, Judith , MCNEILL, Eric , MUNDT, Cornelia, Anne , NAKAJIMA, Katsumasa , NEWCOMBE, Richard, Vaughan , PALERMO, Mark, G. , SCHWEIGHOFFER, Tamas , YU, Bing , WINKELBACH, Katharina , ZHANG, Qiang , BRESSON, Laura , COLLAND, Frédéric , MARAGNO, Ana, Leticia , ROCCHETTI, Francesca , BURGER, Matthew, T.
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公开(公告)号：EP4251209A1
公开(公告)日：2023-10-04
申请号：EP21827768.9
申请日：2021-11-23
发明人： CHEN, Zhuoliang , D'ALESSIO, Joseph, Anthony , MCNEILL, Eric , NAKAJIMA, Katsumasa , NEWCOMBE, Richard, Vaughan , PALERMO, Mark, G. , YU, Bing , ZHANG, Qiang , COLLAND, Frederic , DAVIDSON, James, Edward Paul , DELACOUR, Lea , DESOS, Patrice , GENESTE, Olivier , KOSTOVA, Vesela , KOTSCHY, Andras , MARAGNO, Ana, Leticia , MURRAY, James, Brooke , NOVAK, Tibor , STARCK, Jérôme , BURGER, Matthew, T.
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公开(公告)号：EP3972651A2
公开(公告)日：2022-03-30
申请号：EP20733328.7
申请日：2020-05-19
发明人： BURGER, Matthew, T. , CHANRION, Maia , COLLAND, Frédéric , CSEKEI, Marton , DELACOUR, Lea , DESOS, Patrice , GENESTE, Olivier , HENLIN, Jean-Michel , KOSTOVA, Vesela , KOTSCHY, Andras , MARAGNO, Ana, Leticia , MCNEILL, Eric , PALERMO, Mark, G. , ROCCHETTI, Francesca , STARCK, Jérôme , YU, Bing , ZHANG, Qiang , PROSZENYÁK, Ágnes , SIPOS, Szabolcs , CHEN, Zhuoliang , NAKAJIMA, Katsumasa , D'ALESSIO, Joseph, Anthony
IPC分类号： A61K47/68
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公开(公告)号：EP1735307B1
公开(公告)日：2012-08-29
申请号：EP05716547.4
申请日：2005-04-06
申请人： Novartis AG
发明人： PALERMO, Mark, G. , SHARMA, Sushil, Kumar , STRAUB, Christopher , WANG, Run-Ming , ZAWEL, Leigh , ZHANG, Yanlin , CHEN, Zhuoliang , WANG, Yaping , YANG, Fan , WRONA, Wojciech , LIU, Gang , CHAREST, Mark, G. , HE, Feng
IPC分类号： C07D207/16 , C07D207/09 , C07D207/06 , C07D403/04 , C07D401/04 , C07D401/12 , C07D413/14 , C07D417/04 , C07D403/12 , C07D405/12 , C07D413/04
CPC分类号： C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
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5.发明公开CYCLIC AMIDE DERIVATIVES INHIBITORS OF THE INHIBITOR OF APOPTOSIS PROTEINS, THEIR PREPARATION, AND THEIR USE 审中-公开环酰胺凋亡蛋白抑制剂，其生产和使用衍生工具，抑制剂
公开(公告)号：EP1902065A2
公开(公告)日：2008-03-26
申请号：EP06760702.8
申请日：2006-06-06
申请人： Novartis AG , Novartis Pharma GmbH
发明人： CHEN, Zhuoliang , PALERMO, Mark, G. , SHARMA, Sushil, K. , SMITH, Troy , STRAUB, Christopher, S. , WANG, Run-Ming, D. , WANG, Yaping , ZAWEL, Leigh
CPC分类号： C07K5/0808 , C07D213/56 , C07D223/10 , C07D223/16 , C07D471/04 , C07D487/04 , C07D487/06 , C07D513/04 , C07K5/06026 , C07K5/06191 , C07K5/0806 , C07K5/0827 , C07K5/1008
摘要： The present disclosure relates to XIAP inhibitor compounds of the formula (I)
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6.发明公开PEPTIDE INHIBITORS OF SMAC PROTEIN BINDING TO INHIBITOR OF APOPTOSIS PROTEINS (IAP) 审中-公开SMAC的蛋白质到的凋亡蛋白抑制剂的结合肽抑制剂（IAP）
公开(公告)号：EP1519918A1
公开(公告)日：2005-04-06
申请号：EP03762570.4
申请日：2003-07-01
申请人： Novartis AG , Novartis Pharma GmbH
发明人： SHARMA, Sushil, Kumar , ZAWEL, Leigh , PALERMO, Mark, G. , CHANDRAMOULI, Nagarajan , BAIR, Kenneth, Walter
IPC分类号： C07D207/08 , C07D207/09 , C07D207/10 , C07D401/12 , A61K31/40
CPC分类号： C07D401/12 , A61K38/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07K5/0806 , C07K5/0808 , C07K5/0821 , C07K5/1008
摘要： The present disclosure relates to XIAP inhibitor compounds of the formula I (I) wherein the substituents are as described in the specification. The inventive compounds are useful as therapeutic agents for the treatment of proliferative disorders, including cancer.
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公开(公告)号：EP3972650A2
公开(公告)日：2022-03-30
申请号：EP20731697.7
申请日：2020-05-19
申请人： Novartis AG
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公开(公告)号：EP3972649A2
公开(公告)日：2022-03-30
申请号：EP20730922.0
申请日：2020-05-19
发明人： BURGER, Matthew, T. , CHANRION, Maia , COLLAND, Frédéric , CSEKEI, Marton , DELACOUR, Lea , DESOS, Patrice , GENESTE, Olivier , HENLIN, Jean-Michel , KOSTOVA, Vesela , KOTSCHY, Andras , MARAGNO, Ana, Leticia , MCNEILL, Eric , PALERMO, Mark, G. , ROCCHETTI, Francesca , STARCK, Jérôme , YU, Bing , ZHANG, Qiang , PROSZENYÁK, Ágnes , SIPOS, Szabolcs , CHEN, Zhuoliang , NAKAJIMA, Katsumasa , D'ALESSIO, Joseph, Anthony , BLANKENSHIP, John, William
IPC分类号： A61K47/68
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公开(公告)号：EP1735307A1
公开(公告)日：2006-12-27
申请号：EP05716547.4
申请日：2005-04-06
申请人： Novartis AG , Novartis Pharma GmbH
发明人： PALERMO, Mark, G. , SHARMA, Sushil, Kumar , STRAUB, Christopher , WANG, Run-Ming , ZAWEL, Leigh , ZHANG, Yanlin , CHEN, Zhuoliang , WANG, Yaping , YANG, Fan , WRONA, Wojciech , LIU, Gang , CHAREST, Mark, G. , HE, Feng
IPC分类号： C07D471/04 , C07D207/09 , C07D207/06 , C07D403/04 , C07D207/08 , C07D487/04 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D409/12 , C07D403/12 , C07D405/12 , A61K31/437
CPC分类号： C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
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