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公开(公告)号：EP3063143B1
公开(公告)日：2018-05-16
申请号：EP14800191.0
申请日：2014-10-29
申请人： Novartis AG
发明人： BAGDANOFF, Jeffrey T. , DING, Yu , HAN, Wooseok , HUANG, Zilin , JIANG, Qun , JIN, Jeff Xianming , KOU, Xiang , LEE, Patrick , LINDVALL, Mika , MIN, Zhongcheng , PAN, Yue , PECCHI, Sabina , PFISTER, Keith Bruce , POON, Daniel , RAUNIYAR, Vivek , WANG, Xiaojing Michael , ZHANG, Qiong , ZHOU, Jianguang , ZHU, Shejin
IPC分类号： C07D405/14 , C07D413/14 , C07D213/73 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D409/04 , C07D241/20 , A61K31/4418 , A61P35/00
CPC分类号： A61K31/497 , A61K31/44 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4965 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , A61K2121/00 , C07D213/73 , C07D241/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D498/04
摘要： The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
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公开(公告)号：EP4313041A1
公开(公告)日：2024-02-07
申请号：EP22776608.6
申请日：2022-03-24
申请人： Novartis AG
发明人： GARDINIER, Kevin Matthew , HEALY, Mark Patrick , JENDZA, Keith , PAN, Yue , WANG, Kate Yaping , YANG, Fan
IPC分类号： A61K31/44 , A61K31/4439 , A61K31/4965
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公开(公告)号：EP2459535A1
公开(公告)日：2012-06-06
申请号：EP10736734.4
申请日：2010-07-28
申请人： Novartis AG
发明人： BARSANTI, Paul, A. , HU, Cheng , JIN, Jeff , KEYES, Robert , KUCEJKO, Robert , LIN, Xiaodong , PAN, Yue , PFISTER, Keith, B. , SENDZIK, Martin , SUTTON, James , WAN, Lifeng
IPC分类号： C07D213/74 , C07D401/04 , C07D401/12 , A61K31/506 , A61P29/00 , A61P35/00
CPC分类号： A61K31/497 , C07D213/74 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides a compound of formula (I), and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a diseease or condition mediated by CDK9.
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4.发明公开
公开(公告)号：EP3063143A1
公开(公告)日：2016-09-07
申请号：EP14800191.0
申请日：2014-10-29
申请人： Novartis AG
发明人： BAGDANOFF, Jeffrey T. , DING, Yu , HAN, Wooseok , HUANG, Zilin , JIANG, Qun , JIN, Jeff Xianming , KOU, Xiang , LEE, Patrick , LINDVALL, Mika , MIN, Zhongcheng , PAN, Yue , PECCHI, Sabina , PFISTER, Keith Bruce , POON, Daniel , RAUNIYAR, Vivek , WANG, Xiaojing Michael , ZHANG, Qiong , ZHOU, Jianguang , ZHU, Shejin
IPC分类号： C07D405/14 , C07D413/14 , C07D213/73 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D409/04 , C07D241/20 , A61K31/4418 , A61P35/00
CPC分类号： A61K31/497 , A61K31/44 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4965 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , A61K2121/00 , C07D213/73 , C07D241/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D498/04
摘要： The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
摘要翻译： 本发明提供式（I）的化合物或其盐; 和这些化合物的治疗用途。 本发明还提供包含这些化合物的药物组合物，以及包含这些化合物与治疗性助剂的组合物。
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公开(公告)号：EP2558450A1
公开(公告)日：2013-02-20
申请号：EP11715682.8
申请日：2011-04-13
申请人： Novartis AG
发明人： ABRAMS, Tinya , BARSANTI, Paul, A. , DING, Yu , DUHL, David , HAN, Wooseok , HU, Cheng , PAN, Yue
IPC分类号： C07D249/08 , C07D403/12 , C07D405/12 , C07D405/14 , A61P35/00 , A61K31/55
CPC分类号： C07D403/12 , A61K31/4196 , A61K31/5377 , A61K45/06 , C07D207/10 , C07D249/08 , C07D405/12 , C07D405/14 , C07D413/14
摘要： The present invention provides triazole compounds of Formula (I) : as further described herein. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula (I), and a method of treating a disorder mediated, at least in part, by KSP in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of a compound of Formula (I).
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公开(公告)号：EP3299367B1
公开(公告)日：2019-12-25
申请号：EP17190132.5
申请日：2014-03-13
申请人： Novartis AG
发明人： AVERSA, Robert John , BARSANTI, Paul Andrew , BURGER, Matthew , DILLON, Michael Patrick , DIPESA, Alan , HU, Cheng , LOU, Yan , NISHIGUCHI, Gisele , PAN, Yue , POLYAKOV, Valery , RAMURTHY, Savithri , RICO, Alice , SETTI, Lina , SMITH, Aaron , SUBRAMANIAN, Sharadha , TAFT, Benjamin , TANNER, Huw , WAN, Lifeng , YUSUFF, Naeem
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D233/88 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/12 , C07D239/42 , C07D471/04 , C07D487/04 , C07D263/58 , C07D491/107 , C07D493/04 , C07D495/04 , C07D498/08 , C07D513/04 , A61K31/444 , A61P35/00
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公开(公告)号：EP2970216B1
公开(公告)日：2017-11-01
申请号：EP14714134.5
申请日：2014-03-13
申请人： Novartis AG
发明人： AVERSA, Robert , BARSANTI, Paul A. , BURGER, Matthew , DILLON, Michael Patrick , DIPESA, Alan , HU, Cheng , LOU, Yan , NISHIGUCHI, Gisele , PAN, Yue , POLYAKOV, Valery , RAMURTHY, Savithri , RICO, Alice , SETTI, Lina , SMITH, Aaron , SUBRAMANIAN, Sharadha , TAFT, Benjamin , TANNER, Huw , WAN, Lifeng , YUSUFF, Naeem
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D213/74 , C07D213/75 , C07D233/88 , C07D401/04 , C07D401/12 , C07D403/04 , C07D237/20 , C07D405/04 , C07D405/12 , C07D239/42 , C07D241/20
CPC分类号： A61K31/5377 , A61K31/444 , A61K31/501 , A61K31/5375 , A61K31/541 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/84 , C07D233/88 , C07D237/20 , C07D237/22 , C07D237/24 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D263/58 , C07D277/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D491/08 , C07D491/107 , C07D493/04 , C07D493/10 , C07D495/04 , C07D498/08 , C07D513/04
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8.发明公开
公开(公告)号：EP2668162A1
公开(公告)日：2013-12-04
申请号：EP12700840.7
申请日：2012-01-20
申请人： Novartis AG
发明人： ANTONIOS-MCCREA, William R. , BARSANTI, Paul A. , HU, Cheng , JIN, Xianming , MARTIN, Eric J. , PAN, Yue , LIN, Xiaodong , PFISTER, Keith B. , RENHOWE, Paul A. , SENDZIK, Martin , SUTTON, James , WAN, Lifeng
IPC分类号： C07D213/74 , C07D401/04 , C07D405/14 , C07D413/14 , C07D491/107 , A61K31/444 , A61K31/505 , A61K31/553 , A61P35/00 , A61P29/00 , A61P9/00 , A61P37/00 , A61P31/18
CPC分类号： C07D401/14 , C07D213/74 , C07D401/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D487/04 , C07D491/107
摘要： The present invention provides a compound of formula (II): where R1 is a substituted alkyl, heterocyclic, or cycloalkyl, group, and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof, and pharmaceutical compositions comprising these compounds. Also provided are methods of using these compounds to treat a disease or condition mediated by CDK9, such as cancers and other conditions described herein.
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公开(公告)号：EP4313042A1
公开(公告)日：2024-02-07
申请号：EP22776609.4
申请日：2022-03-24
申请人： Novartis AG
发明人： HEALY, Mark Patrick , PAN, Yue , WANG, Kate Yaping
IPC分类号： A61K31/44 , A61K31/4439 , A61K31/4965
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公开(公告)号：EP3299367A1
公开(公告)日：2018-03-28
申请号：EP17190132.5
申请日：2014-03-13
申请人： Novartis AG
发明人： AVERSA, Robert John , BARSANTI, Paul Andrew , BURGER, Matthew , DILLON, Michael Patrick , DIPESA, Alan , HU, Cheng , LOU, Yan , NISHIGUCHI, Gisele , PAN, Yue , POLYAKOV, Valery , RAMURTHY, Savithri , RICO, Alice , SETTI, Lina , SMITH, Aaron , SUBRAMANIAN, Sharadha , TAFT, Benjamin , TANNER, Huw , WAN, Lifeng , YUSUFF, Naeem
IPC分类号： C07D403/12
摘要： The present invention provides compounds of Formula (I)
as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.摘要翻译： 本发明提供如本文所述的式（I）的化合物及其盐，以及这些化合物用于治疗与Raf激酶活性相关的病症的治疗用途。 本发明进一步提供了包含这些化合物的药物组合物，以及包含这些化合物和治疗剂的组合物。
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