公开(公告)号：EP2909182A1

公开(公告)日：2015-08-26

申请号：EP13847106.5

申请日：2013-10-18

申请人： Novartis AG ,  Array Biopharma, Inc.

发明人： KRELL, Christoph, Max ,  MISUN, Marian ,  NIEDERER, Daniel, Andreas ,  PACHINGER, Werner, Heinz ,  WOLF, Marie-christine ,  ZIMMERMANN, Daniel ,  LIU, Weidong ,  STENGEL, Peter, J. ,  NICHOLS, Paul

IPC分类号： C07D235/06 ,  A61K31/4184 ,  A61P35/00

CPC分类号： A61K31/4184 ,  A61K9/0053 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K45/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  C07B2200/13 ,  C07D235/06 ,  C07D235/08 ,  C30B7/08 ,  C30B29/54

摘要： The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.