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公开(公告)号：EP2909182A1
公开(公告)日：2015-08-26
申请号：EP13847106.5
申请日：2013-10-18
申请人： Novartis AG , Array Biopharma, Inc.
发明人： KRELL, Christoph, Max , MISUN, Marian , NIEDERER, Daniel, Andreas , PACHINGER, Werner, Heinz , WOLF, Marie-christine , ZIMMERMANN, Daniel , LIU, Weidong , STENGEL, Peter, J. , NICHOLS, Paul
IPC分类号： C07D235/06 , A61K31/4184 , A61P35/00
CPC分类号： A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
摘要： The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
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公开(公告)号：EP3036227B1
公开(公告)日：2020-01-08
申请号：EP14838336.7
申请日：2014-08-21
发明人： HAN, Chong , GREEN, Keena , GOSSELIN, Francis , SCALONE, Michelangelo , NICHOLS, Paul J. , LIU, Weidong , STENGEL, Peter J. , SHAKYA, Sagar , CRANE, Zackary D. , SPENCER, Keith L.
IPC分类号： C07D401/00 , C07D403/00
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公开(公告)号：EP3262042A1
公开(公告)日：2018-01-03
申请号：EP16709228.7
申请日：2016-02-26
发明人： STULTS, Jeffrey , LINDEMANN, Christopher M. , SPENCER, Keith L. , LIU, Weidong , LUBACH, Joseph
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06
摘要： Disclosed are crystalline forms of (R)—N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, and salts, solvates, and hydrates thereof, and pharmaceutical compositions, formulations and a process of manufacturing thereof.
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公开(公告)号：EP4306171A2
公开(公告)日：2024-01-17
申请号：EP23211278.9
申请日：2013-10-18
发明人： KRELL, Christoph, Max , MISUN, Marian , NIEDERER, Daniel, Andreas , PACHINGER, Werner, Heinz , WOLF, Marie-Christine , ZIMMERMANN, Daniel , LIU, Weidong , STENGEL, Peter, J. , NICHOLS, Paul
IPC分类号： A61P35/00
摘要： The present invention relates to a pharmaceutical composition comprising crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide.
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公开(公告)号：EP1924594A2
公开(公告)日：2008-05-28
申请号：EP06800088.4
申请日：2006-07-17
发明人： SEIWERT, Scott D. , BLATT, Lawrence M. , ANDREWS, Steven W. , MARTIN, Pierre , SCHUMACHER, Andreas , BARNETT, Bradley R. , EARY, C., Todd , KAUS, Robert , KERCHER, Timothy , LIU, Weidong , LYON, Michael , NICHOLS, Paul , WANG, Bin , SAMMAKIA, Tarek , KENNEDY, April , JIANG, Yutong
IPC分类号： C07K5/12 , A61K38/00 , A61P31/14 , C07D209/44 , C07C231/02 , C07C269/00 , C07D207/16
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/1793 , A61K38/212 , A61K38/217 , A61K38/2292 , A61K38/55 , C07D471/04 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae (I) through general Formula (VIII), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
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公开(公告)号：EP3154959B1
公开(公告)日：2019-07-10
申请号：EP15726455.7
申请日：2015-05-14
发明人： ALLEN, Shelley , ANDREWS, Steven W. , BAER, Brian , CRANE, Zackary , LIU, Weidong , WATSON, Daniel John
IPC分类号： A61K45/06 , A61K9/00 , A61K31/506 , C07D207/16 , C07D403/12 , C07D401/14 , C07D405/14 , C07D403/14
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7.发明公开1-((3S,4R)-4-(3-FLUOROPHENYL)-1-(2-METHOXYETHYL)PYRROLIDIN-3-YL)-3-(4-METHYL-3-(2-METHYLPYRIMIDIN-5-YL)-1-PHENYL-1H-PYRAZOL-5-YL)UREA AS A TRKA KINASE INHIBITOR 有权1 - （（3S，4R）-4-（3- FLUORPHENYL）-1-（2-甲氧基乙基）吡咯烷-3-基）-3-（4-甲基-3-（2-甲基嘧啶-5-基） - 1-苯基-1H-吡唑-5-YL）HARNTOFF ALS EIN TRKA-激酶-HEMMER
公开(公告)号：EP3154959A1
公开(公告)日：2017-04-19
申请号：EP15726455.7
申请日：2015-05-14
发明人： ALLEN, Shelley , ANDREWS, Steven W. , BAER, Brian , CRANE, Zackary , LIU, Weidong , WATSON, Daniel John
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D403/14 , A61K31/4155
CPC分类号： A61K31/506 , A61K9/0053 , A61K45/06 , C07D207/16 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14
摘要： Provided is Compound (I) or a pharmaceutically acceptable salt thereof, which is an inhibitor of TrkA kinase and is useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation and inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis, pelvic pain syndrome, diseases related to an imbalance of the regulation of bone remodeling, and diseases resulting from Connective Tissue Growth Factor aberrant signaling.
摘要翻译： 提供作为TrkA激酶抑制剂的化合物（I）或其药学上可接受的盐，可用于治疗可用TrkA激酶抑制剂如疼痛，癌症，炎症和炎性疾病，神经变性疾病治疗的疾病 ，某些传染病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎，骨盆疼痛综合征，与骨重塑调节失调有关的疾病，以及由结缔组织生长因子异常信号传导引起的疾病。
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公开(公告)号：EP4306171A3
公开(公告)日：2024-04-03
申请号：EP23211278.9
申请日：2013-10-18
发明人： KRELL, Christoph, Max , MISUN, Marian , NIEDERER, Daniel, Andreas , PACHINGER, Werner, Heinz , WOLF, Marie-Christine , ZIMMERMANN, Daniel , LIU, Weidong , STENGEL, Peter, J. , NICHOLS, Paul
IPC分类号： C07D235/06 , A61K31/4184 , A61P35/00
摘要： The present invention relates to a pharmaceutical composition comprising crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide.
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公开(公告)号：EP3702351A1
公开(公告)日：2020-09-02
申请号：EP19211405.6
申请日：2013-10-18
发明人： KRELL, Christoph, Max , MISUN, Marian , NIEDERER, Daniel, Andreas , PACHINGER, Werner, Heinz , WOLF, Marie-Christine , ZIMMERMANN, Daniel , LIU, Weidong , STENGEL, Peter, J. , NICHOLS, Paul
IPC分类号： C07D235/06 , A61K31/4184 , A61P35/00
摘要： The present invention relates to a pharmaceutical composition comprising crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, at least one sugar, and at least one cellulose-derivative excipient.
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公开(公告)号：EP3694853A1
公开(公告)日：2020-08-19
申请号：EP18796238.6
申请日：2018-10-10
发明人： EARY, Charles Todd , SPENCER, Stacey , CRANE, Zack , CHANDO, Katelyn , ASSELIN, Sylvie , LIU, Weidong , WELCH, Mike , COOK, Adam , KOLAKOWSKI, Gabrielle R. , METCALF, Andrew T. , MORENO, David A. , TANG, Tony P.
IPC分类号： C07D471/04 , C07D519/00
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