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公开(公告)号：EP1763547A1
公开(公告)日：2007-03-21
申请号：EP05770095.7
申请日：2005-06-29
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
IPC分类号： C08F287/00 , G02B1/04
CPC分类号： C08F290/068 , C08F230/08 , G02B1/043 , C08L51/085
摘要： The present invention provides silicone hydrogel materials which can be lathed at room temperature and have a high oxygen permeability and a water content of from about 18% to 55% by weight. In addition, the invention provides contact lenses comprising a silicone hydrogel material of the invention.
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公开(公告)号：EP1570011A1
公开(公告)日：2005-09-07
申请号：EP03809755.6
申请日：2003-10-31
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C09D11/10 , C09D11/14 , G02C7/04 , B29D11/00 , C09D201/00
CPC分类号： C09D11/36 , C09D11/101 , G02B1/043
摘要： An aqueous ink comprising containing a colorant and a radiation-curable oligomer or polymer containing H-active groups bonded to the oligomer or polymer backbone, some or all of whose hydrogen atoms have been substituted by radicals of a N-hydroxyalkyl (meth)acrylamide. Methods for printing the inventive inks upon medical devices, such as contact lenses, are also disclosed.
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3.发明公开
公开(公告)号：EP1817362A1
公开(公告)日：2007-08-15
申请号：EP05807368.5
申请日：2005-11-21
申请人： Novartis AG , Novartis Pharma GmbH
摘要： The present invention provides a water-soluble crosslinkable poly(oxyalkylene)containing prepolymer. The crosslinkable poly(oxyalkylene)-containing copolymer prepolymer of the invention is prepared by reacting an amine-capped poly(oxyalkylene)containing polyamide with a multifunctional compound having at least one one ethylenically unsaturated group and a function group coreactive with the capping amine groups of the amine-capped poly(oxyalkylene)-containing polyamide. The amine-capped poly(oxyalkylene)-containing polyamide is a copolymerization production of a mixture comprising: (a) at least one poly(oxyalkylene)diamine, (b) optionally at least one organic dior poly-amine, (c) at least one dicarboxyl derivative, (d) optionally at least one polycarboxyl derivative, and (e) a carbodiimide. The crosslinkable poly(oxyalkylene)-containing prepolymer of the invention can find use in economically producing contact lenses which have improved thermal stability. In addition, the present invention provides method for making a medical device, preferably an ophthalmic device, more preferably a contact lens.
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公开(公告)号：EP1913029A1
公开(公告)日：2008-04-23
申请号：EP06776670.9
申请日：2006-08-08
申请人： Novartis AG , Novartis Pharma GmbH
CPC分类号： G02B1/043 , C08L51/085
摘要： The present invention provides silicone hydrogel materials having relatively high oxygen permeability and a relatively low modulus. The relatively-low modulus is achieved by adding a chain transfer agent into a polymerizable fluid composition in an amount sufficient to provide to the resultant silicone hydrogel material with a reduced modulus. In addition, the invention provides silicone hydrogel contact lenses comprising a silicone hydrogel material of the invention, a method for making a silicone hydrogel material of the invention, and a method for making a silicone hydrogel contact lens of the invention.
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公开(公告)号：EP1561131A1
公开(公告)日：2005-08-10
申请号：EP03788990.4
申请日：2003-10-31
申请人： Novartis AG , Novartis Pharma GmbH
CPC分类号： C08F20/58 , C08B37/0021 , C08L5/02 , G02B1/043 , Y10S525/937
摘要： An ophthalmic lens comprising the cross-linked product of a first polymer, wherein said first polymer is a radiationcurable (meth)acrylamidoalkyl derivative of an oligomer or polymer containing a plurality of H-active groups, wherein said lens transmits at least 70% of visible light.
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公开(公告)号：EP1534767A1
公开(公告)日：2005-06-01
申请号：EP03787788.3
申请日：2003-08-13
申请人： Novartis AG , Novartis Pharma GmbH
CPC分类号： C08G18/672 , C08G18/678 , G02B1/043 , C08L75/04 , C08G18/6677
摘要： The present invention provides a radiation-curable prepolymer. The radiation-curable prepolymer of the invention is prepared by reacting an isocyanate-capped polyurethane with an ethylenically unsaturated amine or an ethylenically unsaturated monohydroxy compound or a mixture thereof, wherein the isocyanate-capped polyurethane is a copolymerization production of: (a) at least one polyalkylene glycol; (b) at least one branching agent having at least three hydroxy groups; and (c) at least one di- or polyisocyanate. The radiation-curable prepolymer of the invention can find use in economically producing contact lenses which have durable, highly elastic soft contact lenses with desired physical properties. In addition, the present invention provides method for making a radiation-curable prepolymer of the invention and for making a medical device, preferably an ophthalmic device, more preferably a contact lens.
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公开(公告)号：EP1969397B1
公开(公告)日：2017-11-08
申请号：EP06829539.3
申请日：2006-12-12
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： G02B1/04 , C08F290/06 , C08F290/14 , C08F283/12
CPC分类号： G02B1/043 , C08F283/12 , C08F290/06 , C08F290/14 , C08L83/10 , C08L51/085
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公开(公告)号：EP1969397A2
公开(公告)日：2008-09-17
申请号：EP06829539.3
申请日：2006-12-12
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： G02B1/04 , C08F290/06
CPC分类号： G02B1/043 , C08F283/12 , C08F290/06 , C08F290/14 , C08L83/10 , C08L51/085
摘要： The present invention provides a method and a formulation for consistently producing a silicone hydrogel material having relatively high oxygen permeability, relatively high ion permeability, and low modulus, and contact lenses prepared from a formulation of the invention or made of a silicone hydrogel material of the invention. The method for making silicone-hydrogel contact lenses, comprising steps of: obtaining a polymerizable fluid composition including a siloxane-containing macromer with ethylenically unsaturated group(s), a radical initiator, and an organonitroxide, wherein the organonitrioxide is a compound having the formula (1) of: in which R1, and R2 are independently H, an alky] group, a cycloalkyl group, an arenyl group, a heterocyclic group, or an aryl group; R3 is an alkyl group, a cycloalkyl group, an arenyl group, a heterocyclic group, or an aryl group; R3 and R2 or R1 and R2 may be joined together to form a cyclic ring structure that may have fused with it another saturated or aromatic ring; each of R1, R2, or R3 may be substituted by at least one member of the group consisting of hydroxy) group, sulfonate group, sulfate group, carboxylate group, amino group, ammonium group, alkoxy group, aryloxy group, silyl group, boryl group, phosphino group, thio group, seieno group, and combinations thereof.
摘要翻译： 本发明提供一种用于一贯生产具有相对高的氧气渗透性，相对高的离子渗透性和低模量的硅氧烷水凝胶材料的方法和制剂，以及由本发明的制剂制备或由本发明的硅氧烷水凝胶材料制成的隐形眼镜 发明。
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公开(公告)号：EP1534767B1
公开(公告)日：2007-11-28
申请号：EP03787788.3
申请日：2003-08-13
申请人： Novartis AG , Novartis Pharma GmbH
CPC分类号： C08G18/672 , C08G18/678 , G02B1/043 , C08L75/04 , C08G18/6677
摘要： The present invention provides a radiation-curable prepolymer. The radiation-curable prepolymer of the invention is prepared by reacting an isocyanate-capped polyurethane with an ethylenically unsaturated amine or an ethylenically unsaturated monohydroxy compound or a mixture thereof, wherein the isocyanate-capped polyurethane is a copolymerization production of: (a) at least one polyalkylene glycol; (b) at least one branching agent having at least three hydroxy groups; and (c) at least one di- or polyisocyanate. The radiation-curable prepolymer of the invention can find use in economically producing contact lenses which have durable, highly elastic soft contact lenses with desired physical properties. In addition, the present invention provides method for making a radiation-curable prepolymer of the invention and for making a medical device, preferably an ophthalmic device, more preferably a contact lens.
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公开(公告)号：EP1799436A1
公开(公告)日：2007-06-27
申请号：EP05782435.1
申请日：2005-08-31
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
CPC分类号： B29D11/00317 , B29D11/00903 , C09D11/101 , G02B1/043 , Y10S425/808
摘要： The present invention generally relates to a method for making made-to-order (MTO) or customized silicone hydrogel lenses which have printed images on and/or below lens surfaces. A preferred method of the invention comprises printing and curing an ink on the molding surface of a mold for molding a single-side molded lens blank, producing the single-sided molded lens blank having a molded surface corresponding to one of the anterior and posterior surfaces of the lens to be produced and having an image embedded in the lens body and below lens surface, and directly lathing the lens blank on the side opposite to the molded surface to form the other lens surface. Colored silicone hydrogel lenses produced according to the invention will be useful as daily wear lenses and extended wear lenses. The lenses will allow alteration or enhancement of a patient's eye color.
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