专利检索 cpc:"C07K2319/7020130101" 第 1 页

1.

发明公开
ARTIFICIAL COMPLEX FOR TETHERING CHROMATIDS OF CHROMOSOMES 审中-实审

公开(公告)号：EP4434533A1

公开(公告)日：2024-09-25

申请号：EP23163092.2

申请日：2023-03-21

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： SCHUH, Melina , WEBSTER, Alexandre

IPC分类号： A61K38/00 , C07K14/435 , C12N15/62 , G01N33/50 , C12N5/075

CPC分类号： A61K38/00 , C12N15/62 , C12N5/0609 , C07K2319/7020130101 , C07K2319/8020130101 , C07K2319/8120130101 , C07K2319/5020130101 , C07K2319/9520130101

摘要： During ageing, egg cells display a gradual loss of cohesin complexes. The cohesin loss eventually causes sister chromatids to separate prematurely, which leads to aneuploidy. The inventors engineered an artificial cohesion system, which is a complex for chromatid or chromosome tethering to reduce, for example, age-related premature separation of sister chromatids in eggs. The artificial cohesion system is a complex, which tethers chromosomes or chromatids so that e.g. the risk of aneuploidy is reduced. Said complex comprises (I) one or more first protein(s) and (II) one or more second protein(s), wherein the (I) first and the (II) second protein(s) each comprise (i) a chromatin-binding component, (ii) a protein-binding region being N-terminal of the chromatin-binding component, (iii) a protein-binding region being C-terminal of the chromatin-binding component. The present invention also includes nucleic acid molecule(s) encoding said complex. Furthermore, several in vitro methods concerning the complex or the nucleic acid molecule(s) encoding said complex also form part of the invention.

2.

发明授权
PROTEIN ENRICHED MICROVESICLES AND METHODS OF MAKING AND USING THE SAME 有权

公开(公告)号：EP3663405B1

公开(公告)日：2024-09-18

申请号：EP19186554.2

申请日：2014-05-15

IPC分类号： C12N15/88 , C12N15/63 , C12N15/09

CPC分类号： C07K2319/7020130101 , C12N2760/2022220130101 , C12P21/02 , C12N9/003 , C12N9/1241 , C12Y105/01003

3.

发明公开
DESIGNED SYNZIP PROTEIN DOMAINS FOR GENERATING ARTIFICIAL NONRIBOSOMAL PEPTIDE SYNTHETASES AND HYBRIDS THEREOF 审中-公开

公开(公告)号：EP4424820A1

公开(公告)日：2024-09-04

申请号：EP23160049.5

申请日：2023-03-03

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , Myria Biosciences AG

发明人： The designation of the inventor has not yet been filed

IPC分类号： C12N9/00

CPC分类号： C12N9/93 , C07K2319/7020130101

摘要： The invention is based on newly derivatized protein interaction adaptor protein sequences based on SYNZIP protein domains. The improved SYNZIP domain variants of the invention were designed to be suitable for interconnecting domains of non-ribosomal peptide synthetases (NRPS) or domains of polyketide synthases (PKS), such as for generating NRPS-PKS hybrid complexes. The invention provides the SYNZIP derivative sequences, NRPS domains containing them, NRPS domain libraries thereof, as well as methods for the production and use in peptide design, screening and production.