-
公开(公告)号：EP2553099B8
公开(公告)日：2015-08-12
申请号：EP11761888.4
申请日：2011-03-30
申请人： Novartis Tiergesundheit AG , The Royal Institution For The Advancement Of Learning/McGill University
IPC分类号： C12N15/12 , C07H21/04 , C12Q1/68 , C07K14/435
CPC分类号： C12Q1/6888 , A61K31/495 , A61K31/555 , C07K14/4354 , C12Q2600/136 , C12Q2600/156
-
公开(公告)号：EP2553099B1
公开(公告)日：2015-06-24
申请号：EP11761888.4
申请日：2011-03-30
IPC分类号： C12N15/12 , C07H21/04 , C12Q1/68 , C07K14/435
CPC分类号： C12Q1/6888 , A61K31/495 , A61K31/555 , C07K14/4354 , C12Q2600/136 , C12Q2600/156
-
公开(公告)号：EP2553099A1
公开(公告)日：2013-02-06
申请号：EP11761888.4
申请日：2011-03-30
CPC分类号： C12Q1/6888 , A61K31/495 , A61K31/555 , C07K14/4354 , C12Q2600/136 , C12Q2600/156
摘要： The invention relates to a method for determining the responsiveness of a Dirofilaria spp. nematode to a macrocyclic lactone, by determining the genotype of the nematode at a position in a P-glycoprotein gene of the nematode corresponding to position 1 1, and optionally to position 618, in SEQ ID NO: 1, wherein the genotype GG at a position corresponding to position 1 1, or at positions corresponding to positions 1 1 and 618, in SEQ ID NO: 1 indicates that the nematode is likely resistant to the macrocyclic lactone. The invention also relates to methods for selecting a treatment to treat an animal infected with macrocyclic lactone resistant Dirofilaria spp nematode, and treating the animal; or for selecting a prophylactic to prevent an animal from becoming infected with a macrocyclic lactone resistant Dirofilaria spp nematode, and providing the prophylactic to the animal. The invention further relates to an isolated nucleic acid having at least 80% sequence identity to SEQ ID NO: 1.
-
-
搜索结果
3 条记录 (耗时 0.011 秒)
