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公开(公告)号：EP2553099B8
公开(公告)日：2015-08-12
申请号：EP11761888.4
申请日：2011-03-30
申请人： Novartis Tiergesundheit AG , The Royal Institution For The Advancement Of Learning/McGill University
IPC分类号： C12N15/12 , C07H21/04 , C12Q1/68 , C07K14/435
CPC分类号： C12Q1/6888 , A61K31/495 , A61K31/555 , C07K14/4354 , C12Q2600/136 , C12Q2600/156
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公开(公告)号：EP2553099A1
公开(公告)日：2013-02-06
申请号：EP11761888.4
申请日：2011-03-30
CPC分类号： C12Q1/6888 , A61K31/495 , A61K31/555 , C07K14/4354 , C12Q2600/136 , C12Q2600/156
摘要： The invention relates to a method for determining the responsiveness of a Dirofilaria spp. nematode to a macrocyclic lactone, by determining the genotype of the nematode at a position in a P-glycoprotein gene of the nematode corresponding to position 1 1, and optionally to position 618, in SEQ ID NO: 1, wherein the genotype GG at a position corresponding to position 1 1, or at positions corresponding to positions 1 1 and 618, in SEQ ID NO: 1 indicates that the nematode is likely resistant to the macrocyclic lactone. The invention also relates to methods for selecting a treatment to treat an animal infected with macrocyclic lactone resistant Dirofilaria spp nematode, and treating the animal; or for selecting a prophylactic to prevent an animal from becoming infected with a macrocyclic lactone resistant Dirofilaria spp nematode, and providing the prophylactic to the animal. The invention further relates to an isolated nucleic acid having at least 80% sequence identity to SEQ ID NO: 1.
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公开(公告)号：EP2553099B1
公开(公告)日：2015-06-24
申请号：EP11761888.4
申请日：2011-03-30
IPC分类号： C12N15/12 , C07H21/04 , C12Q1/68 , C07K14/435
CPC分类号： C12Q1/6888 , A61K31/495 , A61K31/555 , C07K14/4354 , C12Q2600/136 , C12Q2600/156
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4.发明公开USE OF AVERMECTIN DERIVATIVE FOR INCREASING BIOAVAILABILITY AND EFFICACY OF MACROCYLIC LACTONES 审中-公开USING A除虫菌素衍生物对增强大环内酯类生物利用度与效果
公开(公告)号：EP2768513A2
公开(公告)日：2014-08-27
申请号：EP12783158.4
申请日：2012-10-18
申请人： Institut National de la Recherche Agronomique (INRA) , The Royal Institution for the Advancement of Learning / McGill University
发明人： LESPINE, Anne , PRICHARD, Roger , MENEZ, Cécile
IPC分类号： A61K31/7048 , A61P33/00 , A61P35/00 , A61P31/12 , A61P25/08
摘要： The present invention relates to the use of avermectin derivative as a drug for the treatment of parasitic infections. The avermectin derivative is represented by the formula (I) wherein: (i) R1 is chosen from the group constituted of —CH(CH3)2, —CH(CH3)CH2CH3, or cyclohexyle, (ii) X represents —CH2CH2—, or —CH═CH—, (iii) R2 is chosen from the group constituted of or —OH group, (iv) R3 is OH or NOH, (v) represents a single bond when R3 is OH, or a double bond when R3 is NOH, as an inhibitor of a membrane-bound protein which transports exogenous compounds out of target cells.
摘要翻译： 本发明涉及使用阿维菌素衍生物作为用于寄生虫感染的治疗的药物。 除虫菌素衍生物由式（I）表示：其中：（ⅰ）R 1是选自下组构成-CH（CH 3）2的，-CH（CH 3）CH 2 CH 3，或cyclohexyls，（ⅱ）X -CH 2 CH 2 darstellt， 或-CH = CH-，（ⅲ）R 2是选自下组的构成或-OH基团，（ⅳ）R 3为OH或NOH，（v）代表单键当R 3是OH，或双键时R3 是NOH，作为其输送外源性化合物出来的靶细胞的膜结合蛋白的抑制剂。
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5.发明公开
公开(公告)号：EP3701954A2
公开(公告)日：2020-09-02
申请号：EP19215890.5
申请日：2012-10-18
申请人： Institut national de recherche pour l'agriculture, l'alimentation et l'environnement , The Royal Institution for the Advancement of Learning / McGill University
发明人： LESPINE, Anne , PRICHARD, Roger , MENEZ, Cécile
IPC分类号： A61K31/7048 , A61P33/00 , A61P35/00 , A61P31/12 , A61P25/08
摘要： The present invention relates to the use of avermectin derivative as a drug for the treatment of parasitic infections. The avermectin derivative is represented by the formula I
wherein:
(i) R 1 is chosen from the group constituted of -CH(CH 3 ) 2 , -CH(CH 3 )CH 2 CH 3 , or cyclohexyle,
(ii) X represents -CH 2 -CH 2 -, or -CH=CH-,
(iii) R 2 is chosen from the group constituted of
or -OH group,
(iv) R 3 is OH or NOH,
(v) ----- represents a single bond when R 3 is OH, or a double bond when R 3 is NOH,
as an inhibitor of a membrane-bound protein which transports exogenous compounds out of target cells.-
6.发明授权
公开(公告)号：EP2768513B1
公开(公告)日：2019-12-25
申请号：EP12783158.4
申请日：2012-10-18
申请人： Institut National de la Recherche Agronomique (INRA) , The Royal Institution for the Advancement of Learning / McGill University
发明人： LESPINE, Anne , PRICHARD, Roger , MENEZ, Cécile
IPC分类号： A61K31/7048 , A61P33/00 , A61P35/00 , A61P31/12 , A61P25/08
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7.发明公开DETECTION AND MONITORING OF RESISTANCE TO AN IMIDAZOTHIAZOLE ANTI-HELMINTHIC IN NEMATODES 审中-公开伊朗伊斯兰堡伊斯兰堡伊斯兰堡IMIDAZOTHIAZOL-ANTIHELMINTHIKUMS
公开(公告)号：EP3019614A1
公开(公告)日：2016-05-18
申请号：EP14823475.0
申请日：2014-07-11
CPC分类号： C12Q1/6888 , C12Q2600/106 , C12Q2600/156
摘要： The present disclosure concerns the determination of the resistance or the susceptibility of a nematode to an imidazothiazole anti-helmintic based on the assessment of the presence of an indel in the Hco-acr-8 gene (or the Hco-acr-8 gene gene ortholog). The present disclosure also provides tools and commercial packages for making such assessment.
摘要翻译： 本公开涉及根据Hco-acr-8基因（或Hco-acr-8基因直向同源物）中indel的存在的评估来确定线虫对咪唑噻唑抗安全性的抗性或易感性， 。 本公开还提供用于进行此类评估的工具和商业包装。
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8.发明公开
公开(公告)号：EP3701954A3
公开(公告)日：2021-04-21
申请号：EP19215890.5
申请日：2012-10-18
申请人： Institut national de recherche pour l'agriculture, l'alimentation et l'environnement , The Royal Institution for the Advancement of Learning / McGill University
发明人： LESPINE, Anne , PRICHARD, Roger , MENEZ, Cécile
IPC分类号： A61K31/7048 , A61P33/00 , A61P35/00 , A61P31/12 , A61P25/08
摘要： The present invention relates to the use of avermectin derivative as a drug for the treatment of parasitic infections. The avermectin derivative is represented by the formula I
wherein:
(i) R 1 is chosen from the group constituted of -CH(CH 3 ) 2 , -CH(CH 3 )CH 2 CH 3 , or cyclohexyle,
(ii) X represents -CH 2 -CH 2 -, or -CH=CH-,
(iii) R 2 is chosen from the group constituted of
or -OH group,
(iv) R 3 is OH or NOH,
(v) ----- represents a single bond when R 3 is OH, or a double bond when R 3 is NOH,
as an inhibitor of a membrane-bound protein which transports exogenous compounds out of target cells.
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