公开(公告)号：EP3037030A4

公开(公告)日：2017-04-19

申请号：EP14838502

申请日：2014-07-14

Applicant: OLYMPUS CORP

Inventor： KUBO KEI ,  ISHIHARA YASUSHIGE

IPC: A61B1/00 ,  A61B1/04 ,  A61B1/045 ,  A61B1/06

CPC classification number: A61B5/0071 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/043 ,  A61B1/045 ,  A61B1/0638 ,  A61B1/0646 ,  G06T5/008 ,  G06T5/50 ,  G06T19/006 ,  G06T19/20 ,  G06T2207/10064 ,  G06T2207/10068 ,  G06T2207/20212

Abstract: Provided is a fluorescence observation apparatus (100) including a light source (3) that radiates illumination light and excitation light onto a subject; a return-light-image generating portion (61) and a fluorescence-image generating portion (62) that generate a return-light image (G1) and a fluorescence image (G2) of the subject, respectively; a fluorescence detecting portion (63) that detects a fluorescence region in the fluorescence image (G2); a return-light-image adjusting portion (65) that adjusts gradation values of the return-light image (G1); a superimposed-image generating portion (66) that generates a superimposed image (G3) by using the return-light image (G1'), in which the gradation values have been adjusted, and the fluorescence image (G2); and a coefficient setting portion (64) that sets, in the case in which the fluorescence region is detected by the fluorescence detecting portion (63), a degree-of-adjustment, by which the gradation values of the return-light image (G1) are adjusted by the return-light-image adjusting portion (65), so that the gradation values of the return-light image (G1) are decreased as compared with the case in which the fluorescence region is not detected by the fluorescence detecting portion (63).

公开(公告)号：EP2412295A4

公开(公告)日：2014-06-04

申请号：EP10755918

申请日：2010-03-16

Applicant: OLYMPUS CORP

Inventor： ISHIHARA YASUSHIGE

IPC: A61B1/04

CPC classification number: A61B1/00057 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  A61B5/0071 ,  A61B5/0084 ,  A61B2560/0233 ,  G06T5/009

公开(公告)号：EP2108300A4

公开(公告)日：2011-08-24

申请号：EP08704204

申请日：2008-01-30

Applicant: OLYMPUS CORP

Inventor： ISHIHARA YASUSHIGE

IPC: A61B1/00

CPC classification number: A61B5/0059 ,  A61B1/043 ,  A61B1/05 ,  A61B1/0607 ,  A61B1/0638 ,  A61B1/0646 ,  A61B5/02007 ,  G01N21/6456

Abstract: The diagnosability of diseased parts is improved by precisely correcting fluorescence images without being affected by specular reflection and without being affected by thick blood vessels. Provided is a fluorescence observation apparatus (1) that includes a light source unit (2) that radiates, onto an observation target site (S), illumination light that is in the wavelength band absorbed by a blood vessel, first excitation light that includes the wavelength band of the illumination light and generates autofluorescence by exciting an autofluorescent substance in the blood vessel, and second excitation light that is in a different wavelength band from the first excitation light and generates agent fluorescence by exciting fluorescent dye that selectively stains normal tissue and abnormal tissue; an image-acquisition unit (15, 16) that obtains respective images by capturing reflected light, autofluorescence, and agent-fluorescence, obtained by radiating the illumination light, and the first and the second excitation light onto the same observation target site (S); and an image processing unit (4) that extracts a blood-vessel image from the obtained reflected-light image, obtains a reference image by applying interpolation to an area in the autofluorescence image corresponding to the extracted blood-vessel image, and corrects the agent-fluorescence image, obtained by the image-acquisition unit, based on the obtained reference image.

公开(公告)号：EP2932882A4

公开(公告)日：2017-01-11

申请号：EP13863259

申请日：2013-12-03

Applicant: OLYMPUS CORP

Inventor： ISHIHARA YASUSHIGE

IPC: A61B1/00 ,  A61B1/04 ,  A61B1/06 ,  G06T5/50

CPC classification number: G01N21/6456 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/0638 ,  G01N2021/6471 ,  G01N2201/061 ,  G02B21/16 ,  G02B23/2423 ,  G02B23/26 ,  G06T5/50 ,  G06T2207/10064 ,  G06T2207/10068 ,  G06T2207/20221

公开(公告)号：EP2926713A4

公开(公告)日：2016-07-20

申请号：EP13859294

申请日：2013-11-22

Applicant: OLYMPUS CORP

Inventor： KUBO KEI ,  ISHIHARA YASUSHIGE ,  SHIDA HIROMI

IPC: A61B1/00 ,  A61B1/04 ,  A61B1/06 ,  G01N21/64 ,  G02B23/24 ,  G02B23/26 ,  H04N5/225

CPC classification number: A61B1/0638 ,  A61B1/00009 ,  A61B1/00186 ,  A61B1/043 ,  G02B23/2484 ,  G02B23/26 ,  H04N2005/2255

Abstract: Provided is an observation apparatus (100) comprising a light source (3) that irradiates a subject (X) with illumination light and special light that acts on a specific region of the subject (X); a return-light-image generating portion (61) that generates a return-light image (G1) by capturing return light coming from the subject (X) due to irradiation with the illumination light; a special-light-image generating portion (62) that generates a special-light image (G2) by capturing signal light coming from the subject (X) due to irradiation with the special light; an extraction portion (63) that extracts the specific region from the special-light image (G2); and an enhancement processing portion (64) that performs enhancement processing, which is based on return-light image information, on the return-light image (G1), in a region corresponding to the extracted specific region.

公开(公告)号：EP2589328A4

公开(公告)日：2014-11-19

申请号：EP11800784

申请日：2011-06-27

Applicant: OLYMPUS CORP

Inventor： WATANABE TOSHIAKI ,  ISHIHARA YASUSHIGE

IPC: A61B1/00 ,  G02B23/24 ,  G06T1/00

CPC classification number: A61B1/00009 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  G02B23/2461 ,  G02B23/2484

公开(公告)号：EP2716202A4

公开(公告)日：2014-10-29

申请号：EP12792635

申请日：2012-05-30

Applicant: OLYMPUS CORP

Inventor： ISHIHARA YASUSHIGE

IPC: A61B1/00 ,  A61B1/04 ,  A61B1/06

CPC classification number: H04N1/02815 ,  A61B1/00009 ,  A61B1/00039 ,  A61B1/043 ,  A61B1/0638

公开(公告)号：EP2556787A4

公开(公告)日：2017-01-18

申请号：EP11765965

申请日：2011-04-07

Applicant: OLYMPUS CORP

Inventor： ISHIHARA YASUSHIGE

IPC: A61B1/00 ,  A61B1/04 ,  A61B1/05 ,  A61B1/06 ,  G06T5/00 ,  G06T5/50

CPC classification number: A61B6/504 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/05 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0669 ,  G06T5/009 ,  G06T5/50

公开(公告)号：EP2979611A4

公开(公告)日：2016-12-14

申请号：EP14773962

申请日：2014-03-03

Applicant: OLYMPUS CORP

Inventor： ISHIHARA YASUSHIGE

IPC: A61B1/00 ,  A61B1/04 ,  G02B23/24 ,  G02B23/26

CPC classification number: A61B5/0071 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/043 ,  A61B1/0638 ,  G02B23/2469 ,  G02B23/2484 ,  G06T5/50 ,  G06T2207/10024 ,  G06T2207/10064 ,  G06T2207/20221 ,  G06T2207/30004

公开(公告)号：EP2745761A4

公开(公告)日：2015-05-27

申请号：EP12823651

申请日：2012-08-08

Applicant: OLYMPUS CORP

Inventor： ISHIHARA YASUSHIGE

IPC: A61B1/00 ,  G02B23/24

CPC classification number: G01N21/64 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  G02B23/2461 ,  G06T5/009

Abstract: Provided is a fluoroscopy apparatus that allows examination with a highly quantitative fluorescence image by sufficiently removing the residual dependence on factors such as distance from a divided image. Employed is a fluoroscopy apparatus (100) including a preprocessing section (46) that multiplies at least one of a fluorescence image and a reference-light image by a coefficient by which distance characteristics of fluorescence intensity and distance characteristics of return-light intensity acquired from a standard sample in advance are made directly proportional to each other to generate a correction fluorescence image and a correction reference-light image; a divided-image generating section (43) that divides the correction fluorescence image by the correction reference-light image to generate a divided image; a threshold-setting section (45) that sets a threshold based on a mean grayscale level of pixels in the divided image; an image-adjusting section (51) that enhances contrast between a region with grayscale levels above the set threshold set by the threshold-setting section and a region with grayscale levels below the threshold in the divided image; and a monitor (50) that displays the divided image with the enhanced contrast.