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公开(公告)号：EP0746268A4
公开(公告)日：1998-04-01
申请号：EP95911032
申请日：1995-02-17
申请人： ORGANOGENESIS INC
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/06 , A61L27/24 , A61L27/34 , A61L27/36 , A61L27/58 , A61F2/04
CPC分类号： A61L27/58 , A61F2/06 , A61F2/3094 , A61F2002/30062 , A61F2002/3024 , A61F2002/30535 , A61F2002/30971 , A61F2210/0004 , A61F2230/0069 , A61F2240/001 , A61F2250/0058 , A61F2310/00365 , A61L27/24 , A61L27/34 , A61L27/3629 , A61L27/3641 , A61L27/3687 , C08L89/06
摘要： This invention is directed to prostheses, which, when implanted into a mammalian host, serve as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the host's living cells. The prosthesis of this invention, in its various embodiments, thus has dual properties: first, it functions as a substitute body part and second, it functions as a bioremodeling template for the ingrowth of host cells.
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公开(公告)号：EP1082057A4
公开(公告)日：2005-06-08
申请号：EP99955204
申请日：1999-06-04
申请人： ORGANOGENESIS INC
发明人： ABRAHAM GINGER A , CARR ROBERT M JR
IPC分类号： A61L27/00 , A61F2/04 , A61F2/06 , A61L27/24 , A61L27/36 , A61L27/40 , A61L27/50 , B29C53/40 , B29C53/56 , A61B17/00 , A61F2/00
CPC分类号： A61L27/3629 , A61L27/24 , A61L27/3641 , A61L27/3687 , A61L27/40 , A61L27/507 , B29C53/40 , B29C53/562
摘要： The invention is directed to bioengineered tubular graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.
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公开(公告)号：EP1018979A4
公开(公告)日：2000-08-09
申请号：EP98920349
申请日：1998-05-08
申请人： ORGANOGENESIS INC
发明人： ABRAHAM GINGER A , CARR ROBERT M JR , KEMP PAUL D , MERCER RYAN , BAKER LINDA
IPC分类号： A61F13/00 , A01N1/02 , A61F2/00 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/28 , A61L27/24 , A61L27/36 , C12N5/08
CPC分类号： A61L27/3687 , A61K35/12 , A61K38/39 , A61L27/24 , A61L27/3695 , A61L2430/40 , Y10S623/917 , Y10S623/92
摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.
摘要翻译： 本发明涉及已被处理以除去通常在天然组织中发现的非胶原成分例如细胞，细胞碎片和其他细胞外基质成分例如蛋白多糖和糖胺聚糖的胶原组织。 用碱，螯合剂，酸和盐处理组织可从胶原组织基质中除去非胶原组分，同时控制溶胀和溶解的量，从而使得到的胶原基质保持其结构组织，完整性和生物重塑性能。 该过程避免了使用对洗涤剂和酶有不利影响的胶原蛋白基质的细胞相容性，强度和生物可再生性的需要。 胶原组织基质用于植入，修复或在哺乳动物宿主中使用。
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4.发明公开
公开(公告)号：EP0831882A4
公开(公告)日：2000-05-03
申请号：EP96923259
申请日：1996-06-07
申请人： ORGANOGENESIS INC
IPC分类号： A61L27/00 , A61F2/00 , A61K38/18 , A61K38/39 , A61L27/24 , C08L89/00 , D01F4/00 , A61K38/17 , A61K38/00 , A61K47/42 , A61L25/00 , C07K14/78
CPC分类号： A61L27/24 , A61F2310/00365 , A61K38/1841 , A61K38/39
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公开(公告)号：EP0607346A4
公开(公告)日：1995-05-10
申请号：EP92922523
申请日：1992-10-07
申请人： ORGANOGENESIS INC
发明人： KEMP PAUL D , CARR ROBERT M JR , MARESH JOHN G , CAVALLARO JOHN , GROSS JEROME
IPC分类号： A61F2/06 , A61F2/00 , A61K38/17 , A61L27/00 , A61L27/24 , A61L27/36 , A61P43/00 , D01F4/00 , A61F2/02 , A01N37/18 , A61K37/12 , C07K3/02
CPC分类号： A61L27/507 , A61F2/06 , A61F2/08 , A61F2310/00365 , A61L27/24 , A61L27/3808 , A61L27/3813 , A61L27/60 , D01F4/00 , Y10S623/901
摘要： The present invention provides improved collagen threads and methods of making and using such threads, including the production of yarn, as well as braided, knitted, and woven articles of manufacture, comprising such threads.
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公开(公告)号：EP1083843A4
公开(公告)日：2005-06-08
申请号：EP99930144
申请日：1999-06-04
发明人： ABRAHAM GINGER A , CARR ROBERT M JR , HUYNH TAM , HAGEN PER OTTO , DAVIES MARK
CPC分类号： A61L27/507 , A61L27/24 , A61L27/3629 , A61L27/40 , B29C53/40 , B29C53/562
摘要： The invention is directed to bioengineered vascular graft support prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.
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公开(公告)号：EP0828453A4
公开(公告)日：2001-01-10
申请号：EP96909660
申请日：1996-03-12
申请人： ORGANOGENESIS INC
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/04 , A61F2/06 , A61F2/08 , A61F2/10 , A61F2/24 , A61F2/28 , A61F2/44 , A61L2/18 , A61L27/24 , A61L27/36 , A61L27/58 , A61B17/00
CPC分类号： A61L27/3691 , A61F2/0077 , A61L2/18 , A61L27/24 , A61L27/3604 , A61L27/3687 , A61L27/58
摘要： This invention is directed to prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patient's living cells. The prosthesis is treated so that it is rendered non-antigenic so as not to elicit a significant humoral immune response. The prosthesis of this invention, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.
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