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公开(公告)号：EP1207819B1
公开(公告)日：2009-03-04
申请号：EP00952603.9
申请日：2000-08-07
申请人： Cook Biotech, Inc.
CPC分类号： A61F2/92 , A61F2002/30235 , A61F2002/30428 , A61F2210/0076 , A61F2220/0025 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0069 , A61F2310/00017 , A61F2310/00365 , A61L27/042 , A61L27/16 , A61L27/18 , A61L27/24 , A61L27/3604 , Y10S623/917 , Y10S623/921 , C08L27/18 , C08L23/12 , C08L67/00 , C08L77/06
摘要： Described are medical devices which are or can be used to form tubular medical devices, and related methods. Preferred devices include tubular grafts of biomaterial having lumen walls which present no seam edge that traverses the entire length of the lumen, illustratively including devices having lumen walls which have a discontinuous seam presenting multiple seam edges. Such a device may include a tubular structure formed by inserting a plurality of extensions (14) of a biomaterial sheet (12) through a plurality of corresponding apertures (16) of the sheet.
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公开(公告)号：EP1408746A4
公开(公告)日：2007-10-31
申请号：EP01987623
申请日：2001-10-09
申请人： DANCU MICHAEL B
发明人： DANCU MICHAEL B , TARBELL JOHN M
CPC分类号： G09B23/28 , Y10S623/916 , Y10S623/917 , Y10S623/921
摘要： A system for hemodynamic simulation comprises a vessel (12) having properties of a blood vessel, a reservoir (14) containing a quantity of fluid, tubing (24) connecting the vessel (12) and reservoir (14), and at least one pump (22) for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel (12) may include mammalian cells attached to its inside. A drive system (44), comprising two reciprocating drive shafts (50, 52) that are coupled by a cam (54), enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and cirumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.
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3.发明授权METHOD FOR THE MANUFACTURE OF RECOMBINANT UNHYDROXYLATED COLLAGEN POLYPEPTIDE FIBRES, AND FIBRES OBTAINED THEREBY 有权工艺生产重组，非羟基化胶原多肽纤维及由其制造的纤维
公开(公告)号：EP1274888B1
公开(公告)日：2005-08-24
申请号：EP01917374.9
申请日：2001-04-09
CPC分类号： D01F4/00 , A61L26/0033 , A61L27/24 , A61L31/044 , C08L89/06 , Y10S623/917
摘要： The present invention relates to a process for the production of fibres of an unhydroxylated recombinant collagen polypeptide, and the fibres obtained thereby, as well as to uses of such fibres as a biomaterial.
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公开(公告)号：EP1217101A2
公开(公告)日：2002-06-26
申请号：EP01125379.6
申请日：1995-04-26
CPC分类号： A61M29/02 , A61F2/0022 , A61F2/07 , A61F2/86 , A61F2/885 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/95 , A61F2/958 , A61F2002/072 , A61F2002/075 , A61F2002/828 , A61F2002/91541 , A61F2002/91558 , A61F2002/9583 , A61F2210/0076 , A61F2220/0025 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2220/0091 , A61F2250/0067 , A61L31/10 , A61M25/0045 , Y10S623/917 , C08L89/06
摘要： Collagen applied to a vascular stent for increasing the biocompatibility of the stent on implantation and method of treatment
摘要翻译： 胶原蛋白应用于血管支架以增加支架植入物的生物相容性和治疗方法
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公开(公告)号：EP1452150B1
公开(公告)日：2013-01-09
申请号：EP04076470.6
申请日：1998-05-08
申请人： ORGANOGENESIS INC.
CPC分类号： A61L27/3687 , A61K35/12 , A61K38/39 , A61L27/24 , A61L27/3695 , A61L2430/40 , Y10S623/917 , Y10S623/92
摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.
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6.发明授权
公开(公告)号：EP1098670B1
公开(公告)日：2003-06-25
申请号：EP99948339.9
申请日：1999-09-20
发明人： CUNANAN, Crystal, M. , QUINTERO, Lillian , HELMUS, Michael, N. , LOSHBAUGH, Christine , SARNER, Chris, H.
CPC分类号： A61L27/3691 , A61L2/0088 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3687 , A61L33/12 , A61L2400/02 , A61L2430/40 , Y10S623/901 , Y10S623/915 , Y10S623/917 , Y10S623/92
摘要： A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of: A) fixing the tissue; B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a cross-linking agent; C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto); and D) subjecting the bioprosthesis to terminal sterilization.
摘要翻译： 一种固定生物组织的方法，以及通过这种方法制备的生物假体装置。 该方法通常包括以下步骤：A）固定组织; B）用i）变性剂，ii）表面活性剂和iii）交联剂的混合物处理组织; C）制造或形成生物假体（例如，形成组织并将任何非生物组分附着于其上）; 和D）对生物假体进行最终灭菌。
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7.发明公开METHOD FOR THE MANUFACTURE OF RECOMBINANT UNHYDROXYLATED COLLAGEN POLYPEPTIDE FIBRES, AND FIBRES OBTAINED THEREBY 有权工艺生产重组，非羟基化胶原多肽纤维及由其制造的纤维
公开(公告)号：EP1274888A1
公开(公告)日：2003-01-15
申请号：EP01917374.9
申请日：2001-04-09
CPC分类号： D01F4/00 , A61L26/0033 , A61L27/24 , A61L31/044 , C08L89/06 , Y10S623/917
摘要： The present invention relates to a process for the production of fibres of an unhydroxylated recombinant collagen polypeptide, and the fibres obtained thereby, as well as to uses of such fibres as a biomaterial.
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8.发明公开Body implants of extracellular matrix and means and methods of making and using such implants 失效细胞基质的身体植入物及其制造和使用这种植入物的方法
公开(公告)号：EP0128706A3
公开(公告)日：1986-04-30
申请号：EP84303665
申请日：1984-05-31
CPC分类号： A61L27/3633 , A61F2/06 , A61F2/10 , A61F2/28 , A61L27/36 , A61L27/3683 , Y10S128/08 , Y10S623/917 , Y10S623/919 , Y10S623/923
摘要： A sterile body implant is derived from a body structure having as its major protein component collagens in the form of extracellular matrix. The body structure is treated to remove cellular membranes, nucleic acids, lipids and cytoplasmic components. Such structures are implanted internally in the body or externally on the body in a variety of medical uses.
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公开(公告)号：EP0110966A1
公开(公告)日：1984-06-20
申请号：EP83902165.0
申请日：1983-05-25
发明人： BELL, Eugene
CPC分类号： A61L27/3608 , A61F2/00 , A61F2/28 , A61F2310/00365 , A61L27/24 , A61L27/365 , A61L27/38 , A61L27/44 , A61L2430/02 , Y10S514/80 , Y10S623/915 , Y10S623/917
摘要： Un équivalent osseux, utile dans la fabrication de prothèses, est préparé à partir d'un réseau de collagène hydraté contracté par des cellules de fibroblaste et contenant une poudre d'os déminéralisé.
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10.发明公开Composite material of de-N-acetylated chitin and fibrous collagen, its production and use 失效去乙酰化胆固醇和纤维胶原的复合材料及其生产和使用
公开(公告)号：EP0038628A3
公开(公告)日：1982-06-09
申请号：EP81301212
申请日：1981-03-20
CPC分类号： C12N11/10 , A22C13/0013 , A22C13/0016 , A61L27/20 , A61L27/26 , A61L33/0011 , C08L5/08 , C12N11/02 , Y10S128/08 , Y10S128/22 , Y10S514/801 , Y10S623/917 , Y10T428/29 , Y10T428/2964 , C08L89/06 , C08L2666/02
摘要： Problems with conventional collagen materials such as insufficient strength are overcome by a composite material of de-N-acetlylated chitin and fibrous collagen. This material may be prepared by bringing the de-N-acetylated chitin and the fibrous collagen into mutual contact in an aqueous acidic medium followed by deacidifying the product obtained. The fibrous collagen can be partially replaced by gelatin and/or soluble collagen. The composite material finds use in medical materials, as an edible casing for food and as a base material for immobilizing an enzyme.
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