公开(公告)号：EP4129200A1

公开(公告)日：2023-02-08

申请号：EP21774074.5

申请日：2021-02-12

Applicant: OSAKA UNIVERSITY

Inventor： TAKEDA, Shuko ,  MORISHITA, Ryuichi

IPC: A61B10/00 ,  A61B3/113

Abstract: A cognitive impairment diagnostic device (1) includes: an obtainer (41) that obtains a distribution map representing a distribution of gaze points of a subject on a movie for cognitive assessment; and a diagnoser (39). The movie for cognitive assessment includes, in time order: a first movie including a first region including an image for encoding displayed in a visually enhanced manner, and a plurality of second regions including normal images displayed without being enhanced; and an assessment movie including a third region including an assessment image similar to the image for encoding and displayed at a same position as the image for encoding without being visually enhanced, and the second regions. The diagnoser (39) calculates, in a distribution map on the assessment movie, a percentage of fixation duration for which the third region is focused on, and makes diagnosis of suspected memory impairment when the percentage of fixation duration is lower than a threshold.

公开(公告)号：EP4527294A1

公开(公告)日：2025-03-26

申请号：EP25150857.8

申请日：2021-02-12

Applicant: OSAKA UNIVERSITY

Inventor： TAKEDA, Shuko ,  MORISHITA, Ryuichi

IPC: A61B5/16 ,  A61B5/00 ,  G16H10/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/30 ,  A61B3/113

Abstract: A cognitive impairment diagnostic device (1) includes: an obtainer (41) that obtains a distribution map representing a distribution of gaze points of a subject on a movie for cognitive assessment; and a diagnoser (39). The movie for cognitive assessment includes, in time order: a first movie including a first region including an image for encoding displayed in a visually enhanced manner, and a plurality of second regions including normal images displayed without being enhanced; and an assessment movie including a third region including an assessment image similar to the image for encoding and displayed at a same position as the image for encoding without being visually enhanced, and the second regions. The diagnoser (39) calculates, in a distribution map on the assessment movie, a percentage of fixation duration for which the third region is focused on, and makes diagnosis of suspected memory impairment when the percentage of fixation duration is lower than a threshold.

公开(公告)号：EP2174666B1

公开(公告)日：2013-12-18

申请号：EP08765314.3

申请日：2008-06-09

Applicant: Daiichi Sankyo Company, Limited ,  Osaka University

Inventor： MORISHITA, Ryuichi ,  SATO, Naoyuki ,  TAKEDA, Shuko

IPC: A61K31/41 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/454 ,  A61P25/28 ,  A61P43/00

CPC classification number: A61K31/41 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/454

Abstract: The present invention provides a medicament for preventing or treating Alzheimer's disease or mild cognitive impairment which is an early state of cognitive impairment including Alzheimer's disease, comprising an angiotensin II receptor blocker as an active ingredient. A prophylactic or therapeutic agent for Alzheimer's disease or mild cognitive impairment which is an early state of cognitive impairment including Alzheimer's disease, comprising an angiotensin II receptor blocker as an active ingredient.

公开(公告)号：EP2174666A1

公开(公告)日：2010-04-14

申请号：EP08765314.3

申请日：2008-06-09

Applicant: Daiichi Sankyo Company, Limited ,  Osaka University

Inventor： MORISHITA, Ryuichi ,  SATO, Naoyuki ,  TAKEDA, Shuko

IPC: A61K45/00 ,  A61K31/41 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/454 ,  A61P25/28 ,  A61P43/00

CPC classification number: A61K31/41 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/454

Abstract: The present invention provides a medicament for preventing or treating Alzheimer's disease or mild cognitive impairment which is an early state of cognitive impairment including Alzheimer's disease, comprising an angiotensin II receptor blocker as an active ingredient.
A prophylactic or therapeutic agent for Alzheimer's disease or mild cognitive impairment which is an early state of cognitive impairment including Alzheimer's disease, comprising an angiotensin II receptor blocker as an active ingredient.

Abstract translation: 本发明提供用于预防或治疗阿尔茨海默病或轻度认知损伤的所有这是在包括阿尔茨海默氏病的认知损害的早期状态，血管紧张素II受体阻断剂，其包含作为活性成分的药物。 用于治疗阿尔茨海默病或轻度认知损害所有的预防或治疗剂，其为在包括阿尔茨海默氏病的认知损害的早期状态，血管紧张素II受体阻断剂，其包含作为活性成分。

公开(公告)号：EP3711680A1

公开(公告)日：2020-09-23

申请号：EP18878289.0

申请日：2018-11-13

Applicant: Osaka University

Inventor： TAKEDA, Shuko ,  MORISHITA, Ryuichi ,  OYAMA, Akane ,  NAKAJIMA, Tsuneo

IPC: A61B10/00 ,  A61B3/113

Abstract: A cognitive impairment diagnostic apparatus (1) includes: a display (10) which displays a video for diagnosis of cognitive impairment on a display surface (11); an imaging unit (21) which captures images of an eye of a subject; a detection unit (37) which detects viewpoints of the subject on the display surface (11) in time series based on the images captured by the imaging unit (21); a creation unit (38) which creates a distribution map representing a distribution of the viewpoints detected by the detection unit (37); a storage unit (32) which stores case characteristic data (310) indicating a characteristic of a viewpoint distribution corresponding to a typical case in cognitive impairment; and a diagnostic unit (39) which diagnoses cognitive impairment of the subject by determining whether the distribution map has the characteristic indicated by the case characteristic data.