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公开(公告)号：EP0781844A1
公开(公告)日：1997-07-02
申请号：EP95934284.1
申请日：1995-10-12
CPC分类号： C07K14/4747 , A61K38/00
摘要： The invention provides an apoptosis-associated gene comprising a nucleotide sequence coding for the amino acid sequence of SEQ ID NO:1. This gene can be utilized for the expression and detection of an apoptosis-associated protein and is useful for the diagnosis and pathological elucidation of various apoptosis-associated diseases or the prophylaxis and therapy of apoptosis-associated diseases through induction or inhibition of apoptosis.
摘要翻译： 本发明提供了包含编码SEQ ID NO：1的氨基酸序列的核苷酸序列的凋亡相关基因。 该基因可用于凋亡相关蛋白的表达和检测，并且可用于通过诱导或抑制凋亡来预防和治疗凋亡相关疾病的各种凋亡相关疾病的诊断和病理学解释。
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公开(公告)号：EP0274532B1
公开(公告)日：1992-09-09
申请号：EP87903751.3
申请日：1987-06-09
发明人： ADACHI, Masakazu
CPC分类号： C07K14/8107 , A61K8/64 , A61K38/00 , A61Q7/00 , Y10S514/88 , Y10S514/884 , Y10S514/886 , Y10S514/887
摘要： A wound-healing drug, an anti-inflammatory drug, a hair tonic, cosmetics, etc. containing ovomacroglobulin as an effective ingredient. They act on the skin, head skin, hair, etc. to show an excellent wound-healing effect, a hair-growing effect, and a skin- and hair-protecting effect.
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公开(公告)号：EP0623598A1
公开(公告)日：1994-11-09
申请号：EP94908099.8
申请日：1993-08-12
发明人： NAKAI, Satoru, 67-4, Aza Minamikawamukai , AIHARA, Koutoku , TANAKA, Hideo , IBA, Hitomi , KAWAI, Kazuyoshi, Haitsu-Soreiyu , ICHIKAWA, Hiroyuki , AKAMATSU, Seiji , SAITO, Fumio , TOMINAGA, Michiaki , ADACHI, Masakazu
IPC分类号： C07D215/22 , A61K31/495
CPC分类号： C07D215/227 , C07D215/38
摘要： Carbostyril derivatives represented by general formula (1), salts thereof, and an apoptosis regulator containing the same as the active ingredient, wherein R represents benzoyl, phenyl-substituted lower alkyl, etc.; R²⁰ represents hydrogen, lower alkyl, etc.; and R²¹ represents hydrogen, lower alkyl, etc. The regulator is useful as antitumor agent, antiretroviral agent, autoimmune disease remedy, immunosuppressant, Alzheimer's disease remedy, hepatic disease remedy, cancer metastasis inhibitor, and so forth.
摘要翻译： 由通式（1）表示的碳代苯甲酸酯衍生物，其盐，和含有与活性成分相同的凋亡调节剂，其中R代表苯甲酰基，苯基取代的低级烷基等; R 2表示氢，低级烷基等; R 2表示氢，低级烷基等。该调节剂可用作抗肿瘤药，抗逆转录病毒药，自身免疫疾病治疗药，免疫抑制剂，阿尔茨海默病治疗药，肝病治疗药，癌转移抑制剂等。
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公开(公告)号：EP0548376A1
公开(公告)日：1993-06-30
申请号：EP92915918.4
申请日：1992-07-16
发明人： KAWAI, Kazuyoshi Haitsu-Soreiyu 502 , KONISHI, Yasue Dai-5 Ainichi-Haitsu 1F-102 , NAKAI, Satoru , ADACHI, Masakazu
IPC分类号： A61K37/02 , A61K31/725
CPC分类号： A61K38/2006 , A61K38/2013 , A61K38/20 , A61K31/715 , A61K2300/00
摘要： An antitumor drug containing a cytokine, particularly IL-1 or IL-2, and heparin as the active ingredients, and a method for treating tumors by administering a cytokine, particularly IL-1 or IL-2, and heparin.
摘要翻译： 包含细胞因子，特别是IL-1或IL-2和肝素作为活性成分的抗肿瘤药物，以及通过施用细胞因子，特别是IL-1或IL-2和肝素来治疗肿瘤的方法。
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6.发明公开METHOD FOR DETERMINING TUMOR-ASSOCIATED GLUCOSE SIDE CHAIN, METHOD FOR DIAGNOSING TUMORS, AND KIT FOR DIAGNOSING TUMORS 失效方法来确定肿瘤糖BOUND侧链方法用于肿瘤的诊断和“KIT” TO。
公开(公告)号：EP0057236A1
公开(公告)日：1982-08-11
申请号：EP80901418.6
申请日：1980-07-25
发明人： ADACHI, Masakazu
IPC分类号： G01N33/58
CPC分类号： G01N33/57469 , G01N33/535 , G01N33/58
摘要： A method for determining tumor-associated glucose side chain (TAG) in the body fluid of mammals, a method for diagnosing tumors through the determination, and a kit for diagnosis of tumors. TAG specifically existing in the body fluid of a patient suffering from a tumor is reacted with lectin to form a TAG-lectin combination entity. The amount of the combination entity or of the remaining is measured to ascertain the presence or absence of tumor cells, the degree of cell growth and the vicissitudes of the cells, thus diagnosing a tumor. The use of a kit containing vegetable lectin and, in some cases, a stabilizer and/or a preservative is particularly convenient for determination of TAG.
摘要翻译： 一种用于在哺乳动物的体液，用于通过所述确定诊断肿瘤的方法确定的采矿肿瘤相关葡萄糖侧链（TAG）的方法，和用于肿瘤的诊断试剂盒。 TAG在来自肿瘤的患者的体液特别现有与凝集素反应，以形成TAG - 凝集素结合的实体。 剩余测量的组合或实体的量，以确定肿瘤细胞中，细胞生长程度和细胞的变迁的存在或不存在，从而诊断肿瘤。 使用的试剂盒含有植物凝集素，并且在一些情况下，稳定剂和/或防腐剂是测定TAG的特别方便。
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公开(公告)号：EP0972519A1
公开(公告)日：2000-01-19
申请号：EP98905773.2
申请日：1998-03-04
发明人： JIN, Tienan , SUGIURA, Kikuya , MORITA, Haruo , IKEHARA, Susumu , SOGO, Shinji , YAMANISHI, Kazuya , ADACHI, Masakazu
CPC分类号： C12N5/0647 , A61K35/17 , A61K35/28 , A61K39/001 , A61K2035/122 , A61K2035/124 , C12N5/0648
摘要： This invention provides a novel immunotolerance inducer which is effective in inducing immunological tolerance without involving any remarkable invasive procedure, thus ensuring the maintenance of a transplanted organ without administration of an immunosuppressant drug. This immunotolerance inducer is either a dual-system inducer comprising a first pharmaceutical composition for portal administration which comprises an effective amount of a tolerogen containing hematopoietic stem cells, hematopoietic progenitor cells, mature lymphocytes or a mixture thereof as the active component and a second pharmaceutical composition for intravenous administration which comprises an effective amount of the above-mentioned tolerogen as the active component or a single-system immunotolerance inducer which comprises an effective amount of a tolerogen containing hematopoietic stem cells, hematopoietic progenitor cells or a mixture thereof as an active component, said single-system immunotolerance inducer being administered in association with radiation.
摘要翻译： 本发明提供了一种新颖的免疫耐受诱导剂，其有效诱导免疫耐受而不涉及任何明显的侵入性过程，从而确保维持移植的器官而不施用免疫抑制剂药物。 该免疫耐受诱导剂是包含用于门静脉给药的第一药物组合物的双系统诱导剂，其包含有效量的含有造血干细胞的耐受原体，造血祖细胞，成熟淋巴细胞或其混合物作为活性成分和第二药物组合物 用于静脉内给药，其包含有效量的作为活性成分的上述耐受原或单系免疫耐受诱导剂，其包含有效量的含有造血干细胞的致敏原，造血祖细胞或其混合物作为活性成分， 所述单系统免疫耐受诱导剂与辐射相关联地施用。
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8.发明公开REMEDY FOR DERMATOPATHY AND METALLOTHIONEIN INDUCER 失效HEILMITTELFÜRHAUTERKRANKUNGEN UND METALLOTHIONEIN-INDUKTOR。
公开(公告)号：EP0583479A1
公开(公告)日：1994-02-23
申请号：EP93903301.5
申请日：1993-02-03
发明人： OTSU, Yoshiro , ARIMA, Yaeno , NAKAJIMA, Katsuyuki , ADACHI, Masakazu , MURAMATSU, Tsutomu , HANADA, Katsumi
IPC分类号： A61K31/12 , A61K31/19 , A61K31/195 , A61K31/44 , A61K37/02 , A61K31/315 , A61K7/48 , A61K7/42
CPC分类号： A61Q19/004 , A61K8/26 , A61K8/35 , A61K8/368 , A61K8/44 , A61K8/4926 , A61K8/64 , A61K8/675 , A61K31/315 , A61K31/40 , A61K31/405 , A61K31/415 , A61K31/44 , A61K38/04 , A61K38/063 , A61K2800/58 , A61Q17/04
摘要： A zinc salt, a zinc complex or a zinc complex salt of a compound selected from among a pyridine-carboxylic acid represented by general formula (1), nicotinamide, picolinamide, 3,4-dihydroxybenzoic acid, an amino acid, a peptide and hinokitiol has the effects of inducing metallothionein and inhibiting sunburn cell production, thus being useful as a cosmetic or medicine for treating or preventing sunburn and treating dermatopathy, radiation damage or the like.
摘要翻译： 选自通式（1）表示的吡啶羧酸，烟酰胺，吡啶甲酰胺，3,4-二羟基苯甲酸，氨基酸，肽和扁柏酚的锌盐，锌络合物或锌络合盐 具有诱导金属硫蛋白和抑制晒伤细胞生成的作用，因此可用作治疗或预防晒伤和治疗皮肤病，辐射损伤等的化妆品或药物。
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公开(公告)号：EP0552373A1
公开(公告)日：1993-07-28
申请号：EP92914177.8
申请日：1992-07-02
发明人： NAKAI, Satoru , AIHARA, Koutoku , MORI, Hitomi , TOMINAGA, Michiaki , ADACHI, Masakazu , ICHIKAWA, Hiroyuki , AKAMATSU, Seiji , SAITO, Fumio
IPC分类号： A61K31/495
CPC分类号： A61K31/496 , A61K31/495
摘要： An apoptosis regulator containing a carbostyril derivative represented by general formula (1) and its salt as the active ingredient, wherein R represents benzoyl which may be substituted by lower alkoxy, and the carbon-to-carbon bond between the positions 3 and 4 of the carbostyril skeleton is either a single or a double bond.
摘要翻译： 含有通式（1）表示的喹诺酮衍生物及其盐作为活性成分的细胞凋亡调节剂，其中R表示可以被低级烷氧基取代的苯甲酰基，以及其中位置3和4之间的碳 - 碳键 喹诺酮骨架是单键或双键。
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公开(公告)号：EP0552373B1
公开(公告)日：1999-10-13
申请号：EP92914177.8
申请日：1992-07-02
发明人： NAKAI, Satoru , AIHARA, Koutoku , MORI, Hitomi , TOMINAGA, Michiaki , ADACHI, Masakazu , ICHIKAWA, Hiroyuki , AKAMATSU, Seiji , SAITO, Fumio
IPC分类号： A61K31/495
CPC分类号： A61K31/496 , A61K31/495
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