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公开(公告)号：EP2251319B1
公开(公告)日：2012-02-08
申请号：EP10174006.6
申请日：2006-09-01
发明人： Torisawa, Yasuhiro , Abe, Kaoru , Muguruma, Yasuaki , Fujita, Shigekazu , Ogawa, Hidenori , Utsumi, Naoto , Miyake, Masahiro
IPC分类号： C07C233/81
CPC分类号： C07D223/16 , C07C231/12 , C07C233/81
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公开(公告)号：EP2644599B1
公开(公告)日：2014-12-10
申请号：EP13174291.8
申请日：2003-10-14
发明人： Goto, Fumitaka , Takemura, Noriaki , Otani, Tadaaki , Hasegawa, Takeshi , Tsubouchi, Hidetsugu , Utsumi, Naoto , Fujita, Shigekazu , Kuroda, Hideaki , Shitsuta, Takuya , Sasaki, Hirofumi
IPC分类号： C07D233/92
CPC分类号： C07D233/92
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公开(公告)号：EP2253619B1
公开(公告)日：2012-03-14
申请号：EP10174397.9
申请日：2005-01-20
IPC分类号： C07D215/227
CPC分类号： C07D215/227
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公开(公告)号：EP4219477A1
公开(公告)日：2023-08-02
申请号：EP23155266.2
申请日：2014-07-16
发明人： Sato, Seiji , Matsuda, Satoshi , Matsumura, Chiharu , Itotani, Motohiro , Shinohara, Toshio , Fujita, Shigekazu , Sakurai, Yohji , Tai, Kuninori , Fukushima, Tae , Kanemoto, Naohide , Okamoto, Takashi
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D403/14 , C07D405/12 , C07D411/12 , C07D411/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D249/04 , C07D249/06 , A61K31/4192 , A61P3/00 , A61P9/00
摘要： This invention relates to a cyanotriazole compound represented by the formula (1):
wherein each symbols are defined in the specification,
or a salt thereof. The compound or a salt thereof stimulates the citric acid cycle activity and/or improves hyperglycemia with less side effects, and excellent safety, and therefore, it is useful for treating and/or preventing diseases or disorders on which citric acid cycle activation and/or improvement of hyperglycemia has a prophylactic and/or therapeutic effect, for example, diabetes, impaired glucose tolerance, insulin resistance, diabetic complications, obesity, dyslipidemia, hepatic steatosis, atherosclerosis and/or cardiovascular disease, as well as diseases or disorders that would benefit from stimulating energy expenditure.-
5.发明公开Process for preparing benzazepine compounds or salts thereof 有权Verfahrenfürdie Zubereitung von Benzazepineverbindungen oder Salzen daraus
公开(公告)号：EP2261215A1
公开(公告)日：2010-12-15
申请号：EP10174000.9
申请日：2006-09-01
发明人： Torisawa, Yasuhiro , Abe, Kaoru , Muguruma, Yasuaki , Fujita, Shigekazu , Ogawa, Hidenori , Utsumi, Naoto , Miyake, Masahiro
IPC分类号： C07D223/16
CPC分类号： C07D223/16 , C07C231/12 , C07C233/81
摘要： This invention provides a process for preparing benzazepine compounds of the formula (1):
wherein X 1 is a halogen atom, R 1 and R 2 are a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and high purity on industrial scale, which are useful as an intermediate for preparing a pharmaceutically active 2,3,4,5-tetrahydro-1H-1-benzazepine compound having vasopressin antagonistic activity.摘要翻译： 本发明提供了制备式（1）的苯并氮杂化合物的方法：其中X 1为卤素原子，R 1和R 2为低级烷基，或其盐以及高产率和高的中间体苯甲酸化合物 其可用作制备具有加压素拮抗活性的药学活性2,3,4,5-四氢-1H-1-苯并氮杂化合物的中间体。
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公开(公告)号：EP2251319A2
公开(公告)日：2010-11-17
申请号：EP10174006.6
申请日：2006-09-01
发明人： Torisawa, Yasuhiro , Abe, Kaoru , Muguruma, Yasuaki , Fujita, Shigekazu , Ogawa, Hidenori , Utsumi, Naoto , Miyake, Masahiro
IPC分类号： C07C233/81
CPC分类号： C07D223/16 , C07C231/12 , C07C233/81
摘要： This invention provides a process for preparing benzazepine compounds of the formula (1):
wherein X 1 is a halogen atom, R 1 and R 2 are a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and high purity on industrial scale, which are useful as an intermediate for preparing a pharmaceutically active 2,3,4,5-tetrahydro-1H-1-benzazepine compound having vasopressin antagonistic activity.-
公开(公告)号：EP4056557A1
公开(公告)日：2022-09-14
申请号：EP22164702.7
申请日：2018-06-29
发明人： Kan, Keizo , Takuwa, Masatoshi , Tanaka, Hirotaka , Fujiwara, Hideto , Yamabe, Hokuto , Matsuda, Satoshi , Ohdachi, Kazuhiro , Hanari, Taiki , Menjo, Yasuhiro , Urushima, Tatsuya , Fujita, Shigekazu
IPC分类号： C07D223/16 , C07D401/14 , C07D401/06 , C07D401/10 , C07D403/06 , C07D405/12 , C07D409/12 , A61P13/12 , A61K31/55
摘要： The present invention provides novel benzazepine compounds of Formula (1), or salts thereof, having vasopressin V 1a and V 2 antagonisms, for use in the treatment, prevention, and/or diagnosis of a disease selected from the group consisting of Meniere's disease, hypertension, edema, ascites, heart failure, renal dysfunction, renal failure, polycystic kidney disease, syndrome of inappropriate vasopressin secretion, hepatic cirrhosis, hyponatremia, hypokalemia, diabetes, circulation insufficiency, kinesia, water metabolism disorder, and ischemic disorder.
In the formula, R 1 is optionally substituted C 1-6 alkyl, etc.; L is -C(=O)-NH-, etc.; Ring A 1 is a hydrocarbon ring, etc.; Ring A 2 is a hydrocarbon ring, etc.; and each of Rings A 1 and A 2 may have at least one substituent.-
8.发明授权
公开(公告)号：EP2261215B1
公开(公告)日：2014-12-31
申请号：EP10174000.9
申请日：2006-09-01
发明人： Torisawa, Yasuhiro , Abe, Kaoru , Muguruma, Yasuaki , Fujita, Shigekazu , Ogawa, Hidenori , Utsumi, Naoto , Miyake, Masahiro
IPC分类号： C07D223/16
CPC分类号： C07D223/16 , C07C231/12 , C07C233/81
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9.发明公开Method for preparing 1-substituted-4-nitroimidazole compound 有权Verfahren zur Herstellung einer 2-Halo-4-Nitroimidazolverbindung
公开(公告)号：EP2644599A1
公开(公告)日：2013-10-02
申请号：EP13174291.8
申请日：2003-10-14
发明人： Goto, Fumitaka , Takemura, Noriaki , Otani, Tadaaki , Hasegawa, Takeshi , Tsubouchi, Hidetsugu , Utsumi, Naoto , Fujita, Shigekazu , Kuroda, Hideaki , Shitsuta, Takuya , Sasaki, Hirofumi
IPC分类号： C07D233/92
CPC分类号： C07D233/92
摘要： The present invention relates to a 1-substituted-4-nitroimidazole compound represented by the general formula (1) or a salt thereof,
(wherein R is a hydrogen atom, a lower alkoxy group-substituted lower alkyl group, a phenyl-lower alkoxy group-substituted lower alkyl group, a cyano-substituted lower alkyl group, a phenyl-lower alkyl group which may have lower alkoxy groups as the substituents in the phenyl ring or a group of the formula -CH 2 R A ; X is a halogen atom or a group of the formula -S(O)n-R 1 ) and method for preparing the same. The compound of the formula (1) is a useful compound as an intermediate for synthesis of various pharmaceutical and agricultural chemicals, particularly, as intermediates for antitubercular agents.摘要翻译： 本发明涉及由通式（1）表示的1-取代-4-硝基咪唑化合物或其盐（其中R为氢原子，低级烷氧基取代的低级烷基，苯基 - 低级烷氧基 取代基低级烷基，氰基取代的低级烷基，可具有低级烷氧基作为苯环中的取代基的苯基 - 低级烷基或式-CH 2 RA基团; X是卤素原子 或式-S（O）n R 1的基团）及其制备方法。 式（1）的化合物是用作合成各种药用和农药的中间体的有用化合物，特别是作为抗结核剂的中间体。
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10.发明公开Process for preparing derivatives of benzoic acid 有权Verfahren zur Herstellung von Benzoesaure Derivaten
公开(公告)号：EP2251319A3
公开(公告)日：2011-03-09
申请号：EP10174006.6
申请日：2006-09-01
发明人： Torisawa, Yasuhiro , Abe, Kaoru , Muguruma, Yasuaki , Fujita, Shigekazu , Ogawa, Hidenori , Utsumi, Naoto , Miyake, Masahiro
IPC分类号： C07C233/81
CPC分类号： C07D223/16 , C07C231/12 , C07C233/81
摘要： This invention provides a process for preparing benzazepine compounds of the formula (1):
wherein X 1 is a halogen atom, R 1 and R 2 are a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and high purity on industrial scale, which are useful as an intermediate for preparing a pharmaceutically active 2,3,4,5-tetrahydro-1H-1-benzazepine compound having vasopressin antagonistic activity.摘要翻译： 本发明提供了制备式（1）的苯并氮杂化合物的方法：其中X 1为卤素原子，R 1和R 2为低级烷基，或其盐以及高产率和高的中间体苯甲酸化合物 其可用作制备具有加压素拮抗活性的药学活性2,3,4,5-四氢-1H-1-苯并氮杂化合物的中间体。
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