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    Immersion microscope objective and laser scanning microscope system using the same
    2.
    发明公开
    Immersion microscope objective and laser scanning microscope system using the same 有权
    Immersionsmikroskopobjektiv und Laserrastermikroskopsystem damit

    公开(公告)号：EP2573608A3

    公开(公告)日：2013-04-17

    申请号：EP12008380.3

    申请日：2008-07-16

    申请人： Olympus Corporation

    发明人： Saito, Masayoshi ,  Yokoi, Eiji ,  Kusaka, Kenichi ,  Horigome, Shuhei ,  Sugizaki, Noriyuki

    IPC分类号： G02B21/02 ,  G02B21/33 ,  G02B9/60 ,  G02B15/163

    CPC分类号： G02B21/0032 ,  G02B9/60 ,  G02B15/163 ,  G02B21/02 ,  G02B21/33

    摘要： An immersion microscope objective formed of thirteen or fewer lens elements includes, in order from the object side, first and second lens groups (G1,G2) of positive refractive power, a third lens group (G3), a fourth lens group (G4) having negative refractive power with its image-side surface being concave, and a fifth lens group (G5) having positive refractive power with its object-side surface being concave. The first lens group (G1) includes, in order from the object side, a lens component that consists of a lens element of positive refractive power (when computed as being in air) and a meniscus lens element having its concave surface on the object side. Various conditions are satisfied to ensure that images of fluorescence, obtained when the immersion microscope objective is used in a laser scanning microscope that employs multiphoton excitation to observe a specimen, are bright and of high resolution. Various laser scanning microscopes are also disclosed.

    摘要翻译： 由十三个或更少的透镜元件形成的浸没显微镜物镜包括从物体侧起依次具有正屈光力的第一和第二透镜组（G1，G2），第三透镜​​组（G3），第四透镜组（G4） 具有负折射力，其图像侧表面是凹形的，并且具有正折射力的第五透镜组（G5），其物体侧表面是凹形的。 第一透镜组（G1）从物体侧依次包括由正屈光力的透镜元件（当被计算为空气时）构成的透镜部件和在物体侧具有凹面的弯月透镜元件 。 满足各种条件以确保当在使用多光子激发观察样品的激光扫描显微镜中使用浸没显微镜物镜时获得的荧光图像是明亮且高分辨率的。 还公开了各种激光扫描显微镜。

    Immersion microscope objective and laser scanning microscope system using the same
    3.
    发明公开
    Immersion microscope objective and laser scanning microscope system using the same 有权
    浸入式显微镜物镜和激光扫描显微镜系统使用相同的

    公开(公告)号：EP2573609A2

    公开(公告)日：2013-03-27

    申请号：EP12008381.1

    申请日：2008-07-16

    申请人： Olympus Corporation

    发明人： Saito, Masayoshi ,  Yokoi, Eiji ,  Kusaka, Kenichi ,  Horigome, Shuhei ,  Sugizaki, Noriyuki

    IPC分类号： G02B21/02 ,  G02B21/33 ,  G02B9/60 ,  G02B15/163

    CPC分类号： G02B21/0032 ,  G02B9/60 ,  G02B15/163 ,  G02B21/02 ,  G02B21/33

    摘要： An immersion microscope objective formed of thirteen or fewer lens elements includes, in order from the object side, first and second lens groups (G1,G2) of positive refractive power, a third lens group (G3), a fourth lens group (G4) having negative refractive power with its image-side surface being concave, and a fifth lens group (G5) having positive refractive power with its object-side surface being concave. The first lens group (G1) includes, in order from the object side, a lens component that consists of a lens element of positive refractive power (when computed as being in air) and a meniscus lens element having its concave surface on the object side. Various conditions are satisfied to ensure that images of fluorescence, obtained when the immersion microscope objective is used in a laser scanning microscope that employs multiphoton excitation to observe a specimen, are bright and of high resolution. Various laser scanning microscopes are also disclosed.

    摘要翻译： 由13个或更少的透镜元件形成的浸没式显微镜物镜从物侧起依次包括正屈光力的第一和第二透镜组（G1，G2），第三透镜​​组（G3），第四透镜组（G4） 具有负的光焦度，其像方表面是凹面，以及具有正光焦度的第五透镜组（G5），其物方表面是凹面。 第一透镜组（G1）从物体侧依次包括由具有正屈光力的透镜元件（当以空气计算时）和具有在物体侧的凹面的弯月形透镜元件构成的透镜组件 。 满足各种条件以确保当在使用多光子激发观察样本的激光扫描显微镜中使用浸没显微镜物镜时获得的荧光图像明亮且具有高分辨率。 还公开了各种激光扫描显微镜。

    Confocal microscope and multiphoton excitation microscope
    5.
    发明公开
    Confocal microscope and multiphoton excitation microscope 有权
    Konfokales Mikroskop und Multiphotonen-Anregungsmikroskop

    公开(公告)号：EP1860480A1

    公开(公告)日：2007-11-28

    申请号：EP07010055.7

    申请日：2007-05-21

    申请人： Olympus Corporation

    发明人： Sasaki, Hiroshi ,  Yokoi, Eiji ,  Nakata, Tatsuo

    IPC分类号： G02B21/00

    CPC分类号： G02B21/16 ,  G02B21/0032 ,  G02B21/004

    摘要： The invention provides a confocal microscope comprising a light source; a light scanning unit (2); an array device (4); a line-beam generating unit (3) for imaging illumination light in the form of a straight line extending, on the array device, in a direction intersecting the scanning direction of the light scanning unit; an objective lens (5) for imaging the illumination light reflected or transmitted at the array device on a specimen; a beamsplitter (6), between the array device (4) and the light scanning unit (2), for splitting off from the illumination light detection light from the specimen; a two-dimensional image-acquisition unit (7) for acquiring the split off detection light; and a control unit (8) for controlling the light scanning unit and the array device, wherein the array device is disposed in an optically conjugate positional relationship with a focal plane of the objective lens, and the control unit performs control so as to synchronize the light scanning unit and the array device. The invention also provides a multiphoton excitation microscope with a beamsplitter (16) between the objective lens (5) and the array device (4).

    摘要翻译： 本发明提供一种包括光源的共焦显微镜; 光扫描单元（2）; 阵列器件（4）; 一个线束产生单元，用于对阵列装置上沿与光扫描单元的扫描方向相交的方向成直线的形式的照明光进行成像; 用于对在样品上的阵列器件反射或透射的照明光进行成像的物镜（5） 在阵列器件（4）和光扫描单元（2）之间的分束器（6），用于从来自样本的照明光检测光分离; 用于获取分离检测光的二维图像获取单元（7）; 以及用于控制光扫描单元和阵列器件的控制单元（8），其中阵列器件与物镜的焦平面以光学共轭位置关系设置，并且控制单元执行控制以使 光扫描单元和阵列设备。 本发明还提供了一种在物镜（5）和阵列装置（4）之间具有分束器（16）的多光子激发显微镜。

    Microscope apparatus
    7.
    发明授权
    Microscope apparatus 有权
    显微镜系统

    公开(公告)号：EP2498116B1

    公开(公告)日：2017-02-15

    申请号：EP12001468.3

    申请日：2012-03-05

    申请人： Olympus Corporation

    发明人： Yokoi, Eiji

    IPC分类号： G02B21/32 ,  G02B21/00

    CPC分类号： G02B21/02 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/32 ,  G02B2207/114

    摘要： A microscope apparatus includes a laser beam source for emitting a laser beam, an objective lens for irradiating a sample with the laser beam, a phase-modulating spatial light modulator placed between the laser beam source and the objective lens at a position optically conjugate with a pupil position of the objective lens, and a beam diameter variable unit placed between the laser beam source and the phase-modulating spatial light modulator for varying a beam diameter of the laser beam incident to the phase-modulating spatial light modulator.

    Microscope apparatus
    8.
    发明公开
    Microscope apparatus 有权
    Mikroskopsystem

    公开(公告)号：EP2498116A1

    公开(公告)日：2012-09-12

    申请号：EP12001468.3

    申请日：2012-03-05

    申请人： Olympus Corporation

    发明人： Yokoi, Eiji

    IPC分类号： G02B21/32 ,  G02B21/00

    CPC分类号： G02B21/02 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/32 ,  G02B2207/114

    摘要： A microscope apparatus includes a laser beam source for emitting a laser beam, an objective lens for irradiating a sample with the laser beam, a phase-modulating spatial light modulator placed between the laser beam source and the objective lens at a position optically conjugate with a pupil position of the objective lens, and a beam diameter variable unit placed between the laser beam source and the phase-modulating spatial light modulator for varying a beam diameter of the laser beam incident to the phase-modulating spatial light modulator.

    摘要翻译： 显微镜装置包括用于发射激光束的激光束源，用于用激光束照射样品的物镜;相位调制空间光调制器，其位于激光束源和物镜之间的光学共轭处的位置 物镜的光瞳位置以及放置在激光束源和相位调制空间光调制器之间的光束直径可变单元，用于改变入射到相位调制空间光调制器的激光束的光束直径。

    Scanning optical microscope
    10.
    发明公开
    Scanning optical microscope 有权
    扫描光学显微镜

    公开(公告)号：EP2827180A1

    公开(公告)日：2015-01-21

    申请号：EP14173633.0

    申请日：2014-06-24

    申请人： Olympus Corporation

    发明人： Shimada, Yoshihiro ,  Ueno, Makio ,  Tamano, Shingo ,  Hayashi, Naoki ,  Yokoi, Eiji

    IPC分类号： G02B21/00 ,  G02B27/42

    CPC分类号： G02B21/0032 ,  G02B21/002 ,  G02B21/0036 ,  G02B21/0096 ,  G02B21/06 ,  G02B21/26 ,  G02B27/4261

    摘要： A scanning optical microscope includes a light source, a light converging optical system, a stage, a scanning unit which displaces an illumination light and the stage relatively, a detecting optical system, and a photodetector. A light modulation element and a relay optical system are disposed on the light converging optical system side of the light source, and a modulated signal having only amplitude changed is input to the light modulation element, and the light modulation element is positioned such that the illumination light emerged from the light modulation element with respect to the modulated signal of a predetermined amplitude coincides with an optical axis of the light converging optical system, and a position of a pupil of the light converging optical system and a position of the light modulation element are conjugate through at least the relay optical system.